Siro New Ameflu Night Time OPV reduces cold symptoms (60ml)

Dosage form Syrup
Specifications Bottle x 60ml
Ingredient Paracetamol, phenylephrine, chlorphenamin
Indication Fever, headache, sneezing, nasal congestion, nasal congestion
Contraindication Prostate hypertrophy, bladder neck obstruction

Ingredient

Composition informationContent
Paracetamol160mg
Phenylephrine2.5mg
Chlorphenamin1mg

Uses

indications

New Ameflu Night Time drug is indicated in the following cases:

temporarily reduce common cold symptoms: mild pain, headache, sore throat, nasal congestion (nasal congestion), cough, nose, sneezing and fever.

Pharmacological

acetaminophen is a metabolic substance that has the activity of phenacetin, which helps to relieve pain by preventing peripheral pain pulses. The drug has an antipyretic effect by inhibiting the central region of the hypothalamus. Acetaminophen is an analgesic - reducing fever that can replace aspirin, but acetaminophen does not have the effect of inflammatory treatment. With equal doses, acetaminophen has the same fever -reducing pain effect as aspirin.

Acetaminophen reduces body temperature in fever but rarely reduces body temperature in normal people. Acetaminophen, with treatment, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding as when using salicylate. When overdose of acetaminophen, metabolic N - Acetyl - P - Benzoquinonimine is toxic to the liver.

Phenylephrine hydrochloride is a sympathetic effect α1, which directly works on the receptors α1 - adrenergic, causing blood vessel contractions and increasing blood pressure. Phenylephrine hydrochloride causes a bradycardia due to reflexes, reduces blood volume during circulation, reduces blood flow through the kidneys, as well as reduces blood into many tissues and organs of the body.

The mechanism of action of α - adrenergic of phenylephrine is due to inhibition of amp production (Camp: Cyclic adenosin - 3 ', 5' - monophosphate) through adenyl cyclase enzyme inhibitor, while β - adrenergic effect is due to adenyl cyclase activity stimulation.

When the nasal mucosa, phenylephrine causes local vasoconstriction, so it reduces the nasal congestion and sinuses due to colds.

Chlorpheniramine Maleatate is a first generation histamine resistance. The drug competes with histamines at H1 histamine receptors on cells acting in the gastrointestinal tract, blood vessels and respiratory tract. The sedative effect of the drug is relatively weak when compared to other first -generation antihistamines.

Dynamic pharmacokinetics

Acetaminophen is quickly absorbed from the digestive tract with peak concentration in plasma reaching about 30-60 minutes after drinking. Acetaminophen is distributed in most body tissues. Acetaminophen through the placenta and present in breast milk. Mounting with plasma proteins is not significant with conventional treatment levels but binding will increase as the concentration increases. The half -life of acetaminophen varies from 1 to 3 hours. Acetaminophen is metabolized mainly in the liver and excreted in urine mainly in the form of glucuronid complex (60 - 80%) and sulphate conjugate (20 - 30%). Under 5% is excreted in the form of unchanged acetaminophen. A small part (less than 4%) is metabolized through the Cytochrom P450 system.

Phenylephrine hydrochloride is unevenly absorbed through the gastrointestinal tract and undergo an early stage metabolism in the intestine and liver thanks to the enzyme monoamine oxidase. Phenylephrine is excreted almost entirely through urine.

Chlorpheniramine Maleate absorbs well when taken and the drug appears in plasma within 30 - 60 minutes. Plasma peak concentration is about 2.5 - 6 hours after drinking. Biology is about 25 - 50%. About 70% of the drug during the circulation associated with the protein. Chlorpheniramine metabolizes fast and high, metabolites include Desmethyl - Didesmethyl Chlorpheniramine and some unknown substances. The drug is excreted mainly in urine in a constant or metabolic form. Only a small amount is seen in the feces. The half -life is 12 - 15 hours and in patients with chronic renal failure.

Before taking Siro New Ameflu Night Time OPV reduces cold symptoms (60ml)

How to use

New Ameflu Night Time is an oral medication. Shake before use.

Dosage

Children under 4 years old

Not used.

Children from 4 to 5 years old

Do not use without a doctor's instructions.

Children from 6 to 11 years old

Take 2 teaspoons (10 ml) every 4 hours. Do not use more than 10 teaspoons (50 ml)/24 hours.

Doctors should recommend that patients stop taking medication and consult a doctor when there is one of the following symptoms:

  • The feeling of restlessness, dizziness or insomnia.

    • This may be a sign of worse pathology.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

    acetaminophen

    Symptoms

    Acetaminophen's poisoning may be used by 1 single -dose or a large dose of acetaminophen (e.g. 7.5 - 10 g per day, for 1-2 days) or for long -term medication. Liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be fatal.

    Nausea, vomiting and abdominal pain (occurring within 24 hours after drinking). After 24 hours, symptoms may include right -lowered pain, often indicating the growth of liver necrosis. Liver damage is most about 3-4 days after taking the drug overdose and can lead to brain disease, hemorrhage, hypoglycemia, brain edema and death.

    How to handle

    Treatment depends on plasma concentrations. Acetylcysteine ​​protects the liver if used for about 24 hours from the overdose of acetaminophen (most effective if used for about 8 hours). The first oral dose is 140 mg/kg (load dose), then give 17 more doses, each dose of 70 mg/kg 4 hours apart. Activated carbon or gastric wash can be done to reduce the absorption of acetaminophen.

    phenylephrine HCl

    Symptoms

    Overdose of phenylephrine increases blood pressure, headache, convulsions, brain hemorrhage, chest drums, extra mind, and paresthesia. Slow heart rate usually occurs early.

    In the treatment of dramatic tachycardia on ventricular, when intravenous injection, if overdose, will cause short or ventricular ventricular tachycardia.

    How to handle

    Hypertension can be overcome by taking α -adrenergic blockers like phentolamine 5 - 10 mg, intravenously; If necessary, can be repeated. Hemorrhage is usually not helpful. Pay attention to symptomatic treatment and general support, medical care.

    chlorpheniramine maleaty

    Symptoms

    Dosage of chlorpheniramine is about 20 - 50 mg/kg body weight.

    Symptoms and overdose signs include a lot of sleep, naughty stimulation often the central nervous system, mental disorders, seizures, apnea, convulsions, anti -muscarin effects, hypertonic reactions and cardiovascular collapse and arrhythmia.

    How to handle

    Treatment of symptoms and supporting life function. Pay special attention to the function of liver, kidneys, respiration, heart and water balance, electrolytes.

    Stomach or vomiting with ipecacuanha syrup. Then, for active carbon and bleach to limit absorption.

    When experiencing hypotension and arrhythmia, it should be actively treated. It is possible to treat convulsions with intravenous diazepam or phenytoin intravenously. May have to be blood transfusion in heavy cases.

    What to do when forgetting 1 dose? Do not use double dose to compensate for the forgotten dose.

    Side Effects

    When using New Ameflu Night Time, you may experience unwanted effects (ADR).

    Common (ADR> 1/100)

  • Neurological: Neurology, restlessness, anxiety, difficulty sleeping, weak, dizzy, pain in the chest, trembling, abnormalities, sleeping from sleep to deep sleep, loss of coordination, headache, mental disorders - movement.
    • Cardiovascular: Hypertension.
  • Skin: pale, white, cold skin, hair erection.
    • Muscarin resistance effect: dry mouth, dense phlegm, blurred vision, urination, constipation, increased gastroesophageal reflux.

    Uncommon (1/1000

  • Cardiovascular: Hypertension with pulmonary edema, arrhythmia, slow heart rate, peripheral vasoconstriction and internal organs reducing perfusion for these organs, brushing chest drums.
    • skin: ban, sensitive reaction (bronchospasm, angioed and anaphylaxis). digestive: Nausea, vomiting, diarrhea, epigastric pain. Hematology: Dehydration (neutropenia, all bloody hemorrhage, leukopenia), anemia. kidney: kidney disease, kidney toxicity when abusing for a long time. Respiratory: Respiratory failure. nerve: excitement, hallucinations, paranoia.

    Rare (ADR

  • Skin: Steven - Johnson syndrome, poisoned epidermal necrosis, Lyell syndrome, acute all -body pustules.
    • Cardiovascular disease: Heartitis into foci, hemorrhage under the pericardium. Hematology: granulocytosis, leukemia, hemolytic anemia, thrombocytopenia.

    Other: Hypersensitivity reaction, convulsions, sweating, muscle pain, abnormalities, extras, sleep disorders, depression, confusion, tinnitus, hypotension, hair loss.

    Notice immediately to the doctor or pharmacist the harmful reactions encountered when using the drug.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    New Ameflu Night Time contraindicated drug in the following cases:

  • People who are sensitive to any ingredients of the drug.
  • Patients who are taking imao drugs (see drug interactions).
  • Children under 4 years old.

    • Caution when used

    acetaminophen, chlorpheniramine and phenylephrine are metabolized in the liver. Therefore, the metabolism of one or more components of the drug may be reduced in patients with liver disease. Need to monitor liver function tests in this patient group. The dose may be needed because of the accumulation of drugs or prolonging the active time may occur in patients with liver dysfunction.

    Do not use this medication for patients with glaucoma. Internal label pressure may occur from chlorpheniramine anti -chlorpheniramine activities, causing acute glaucoma. Moreover, the sympathetic activities of phenylephrine can also increase the glaucoma.

    Do not use with any other drugs containing acetaminophen. Do not use with the flu, cold or other nose. Should find medical advice immediately in case of overdose, even if the patient feels healthy.

    Caution and special warning when using drugs containing active ingredients Acetaminophen:

  • Doctors need to warn the patient about signs of serious skin reactions such as Steven - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten), or Lyell syndrome, acute overseas acne syndrome (AGEP).
  • Patients need to stop taking acetaminophen and see a doctor as soon as the rash or other skin manifestations or sensitive reactions during treatment. Patients with a history of such reactions should not use acetaminophen -containing preparations.

    • Sometimes skin reactions include itchy and urticaria rash; Other sensitive reactions include larynx edema, angioedema and anaphylactic reactions that may rarely occur. Platelets, leukopenia and all bloody hematuria have occurred with the use of p-aminophenol derivatives, especially when used for large doses. Neutral leukemia and thrombocytopenic hemorrhage occur when using acetaminophen. Rarely loss of granulocytes in patients using acetaminophen.

  • Using many preparations containing acetaminophen and can lead to harmful consequences (such as overdose acetaminophen).
  • Be cautious when using acetaminophen for patients with anemia before, liver failure, kidney failure, alcoholic, chronic malnutrition or dehydration.

    • phenylephrine hydrochloride:

  • Be careful when taking the drug in patients with bronchial asthma, intestinal obstruction, hyperthyroidism, benign prostatic hypertrophy. When using the drug, there is an irritant symptom, dizziness, sleep disorders must stop the drug and notify the medical staff.

    • chlorpheniramine maleat:

  • Due to the anti -Muscarin effect should be cautious when used for people with prostate hypertrophy, urinary obstruction, duodenal pylorus, and exacerbate in patients with myasthenia gravis.

    • The sedative effect of chlorpheniramine increases when drinking alcohol and when used simultaneously with other sedatives.

    There is a risk of respiratory complications, respiratory decline and apnea in people with obstructive pulmonary disease or in young children. Must be cautious when chronic lung disease, shortness of breath or shortness of breath, bronchial asthma.

    There is a risk of tooth decay in patients treated for a long time, due to the anti -Muscarin effect causing dry mouth.

  • Use medication with the elderly (> 60 years old) because these people often increase sensitivity to Muscarin resistance.

    • Children are very sensitive to unwanted effects and can cause nervous irritation, so it is very careful when using chlorpheniramine for these patients, especially in children with a history of seizures.

    This drug contains:

  • Sorbitol and Sucralose. Patients with rare genetic problems galactose intolerance, fructose intolerance, or glucose - galactose are not used by this drug.

    • Propylene can cause symptoms like drunkenness.

  • Amaranth Red and Brilliant Blue, which can cause allergic reactions.

    • This drug contains 19.5 mg of sodium benzoate in every 10 ml equivalent to 1.95 mg/ml. Sodium benzoat can increase the risk of jaundice and yellow eyes in infants (4 weeks of age or less).

    The ability to drive and operate machinery

    Use carefully while driving, operating machinery.

    Pregnancy

    only used for pregnant women when really necessary, consideration of harm caused by drugs. Do not use for women who are pregnant in the last 3 months of pregnancy.

    The period of breastfeeding

    must be very cautious when taking medicine for breastfeeding women, need to consider or do not breastfeed or do not take the drug, depending on the level of the drug for the mother.

    Drug interaction

    cholestyramine reduces acetaminophen absorption speed. Therefore, within 1 hour, do not take cholestyramine if you want to maximize pain.

    metoclopramide and domperidone increases the absorption of acetaminophen. However, there is no need to avoid using these drugs.

    Long -term drinking high -dose acetaminophen takes a slight anticoagulant effect of COUMARIN and conductive derivatives.

    It is necessary to pay attention to the likelihood of causing serious hypothermia in patients to simultaneously use phenothiazine and cooling therapy (such as acetaminophen).

    Drinking too much alcohol and long -term increases the risk of acetaminophen's liver toxicity.

    Anti -seizure drugs (including phenytoin, barbiturate, carbamazepine), isoniazid, anti -tuberculosis drugs that can increase the toxicity of acetaminophen on the liver.

    Probenecid may reduce the elimination of acetaminophen and increase the sale time in plasma of acetaminophen.

    Do not take this medication while taking Monoamin oxidase inhibitors (IMAO) (some drugs to treat depression, mental or emotional disease, or Parkinson's disease) or within 2 weeks after stopping the IMAO medications. If you do not know whether the drug is taking as prescribed by a doctor containing imao or not, must consult a doctor or pharmacist before taking this drug.

    Simultaneous use of phenylephrine with amines that have a sympathetic nerve effect can increase the unwanted effects of cardiovascular.

    Phenylephrine may reduce the effectiveness of beta blockers and anti -hypertension drugs (including debilisquine, guanethidine, reserpine, methyldopa). Risk of hypertension and unwanted effects on cardiovascular can be increased.

    Three -round antidepressants (Amitriptyline, imipramine): may increase the unwanted effects of phenylephrine.

    Simultaneous use of phenylephrine with mushroom alcaloid (ergotamine and methylsergide): increases the poisoning of chicken spurs.

    Simultaneous use of phenylephrine with digoxin: increases the risk of abnormal heartbeat or heart attack.

    Simultaneous use of phenylephrine with atropine will block the slow effect of the reflective heart rate caused by phenylephrine.

    ethanol or sedatives that cause sleep can increase the central nervous system inhibitors of chlorpheniramine.

    chlorpheniramine inhibits phenytoin metabolism and can lead to phenytoin poisoning.

    CYP3A4 inhibitors such as: dasatinib, pramilintide increases the concentration or effect of chlorpheniramine.

    Medicines reduce the effects of cholinesterase inhibitors and betahistidin.

    Storage

    At temperatures from 15 ° C to 30 ° C.

    Other drugs

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