Siro Rutantop Mebiphar Treatment of allergic rhinitis, urticaria (70ml)

Dosage form Syrup
Specifications Jar
Ingredient Fexofenadin hydrochlorid

Ingredient

Thành phần cho 5ml

Composition information	Content
Fexofenadin hydrochlorid	30mg

Uses

Indications

syrup rutantop indicated symptomatic treatment in the following cases:

Seasonal allergic rhinitis.

Pharmacological group: 2nd generation antihistamine drugs

Fexofenadin has a specific antagonistic and selective effect on peripheral H1 receptors. The drug is a metabolic substance that has the activity of terfenadin, competing with histamines at H1 receptors in the digestive tract, blood vessels and respiratory tract, but no toxicity for the heart due to no inhibition of potassium channel related to myocardial cycles.

Fexofenadin has no significant effects on acetylcholin, dopamine antagonism and has no effect of inhibiting receptors of Alpha, or Beta - Adrenegic. At the treatment dose, the drug does not cause sleep or affects the central nervous system. The drug has a fast and prolonged effect due to slow -attached drugs into the H1 receptor to form a sustainable complex and slowly separated.

Pharmacokinetics

absorption

Good absorption drug when taken oral and start to work after drinking 60 minutes. The peak concentration in the blood is achieved after 2-3 hours. Fat -rich foods reduce the peak concentration in plasma by about 17% and extend the time to reach the peak concentration of the drug (until about 4 hours). Anti -antihistamine effect lasts more than 12 hours.

Distribution

The ratio of the plasma protein of the drug is 60 - 70%, mainly with albumin and alpha1 - Glycoprotein acid. Fexofenadin does not pass the brain barrier.

Metabolism

Fexofenadin is very small metabolized (about 5%, mainly in the intestinal mucosa, only about 0.5 -1.5% are metabolized in the liver thanks to the cytochrom paso enzyme into non -active substance). About 3.5% of fexofenadin dose metabolized through phase II (not related to the cytochrom P450 enzyme system) into methyl ester derivatives. This metabolic substance is only seen in the stool, so there may be the participation of intestinal bacteria in metabolism.

Elimination

FEXOFENADIN SELLING Time is about 14.4 hours, longer (31 - 72%) in kidney failure people. The drug excreted mainly in feces (approximately 80%) and urine (11 - 12%) in constant form.

Elimination with ineffective blood decomposition.

Before taking Siro Rutantop Mebiphar Treatment of allergic rhinitis, urticaria (70ml)

How to use

syrup rutantop is taken orally, shaking well before use.

Note: Do not take Syrup Rutantop with fruit juice. Time to use Syrup Rutantop does not endure the meal.

Dosage

Dosage recommendations for treatment of allergic rhinitis, indefinite urticaria:

Common doses for adults and children over 12 years: 60 mg (10 ml) x 2 times/day or 180 mg (30 ml) x 1 time/day.

The usual dose for children from 2 - 11 years old: 30 mg (5 ml) x 2 times/day.

Dosage recommendations for chronic urticaria treatment:

Children from 6 months to 2 years: 15 mg (2.5 ml) once × 2 times/day.

elderly and kidney failure:

Children aged 12 years and older and adults with renal failure, the elderly: Start taking a dose of 60 mg (10 ml) oral 1 time/day, adjust the dose according to the kidney function.

Children from 2 to 11 years old with renal failure: Start using 30 mg (5 ml) x 1 time/day.

Children from 6 months to under 2 years of age: Start using 15 mg (2.5 ml) × 1 time/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? If there are symptoms such as drowsiness, dizziness, dry mouth, immediately notify the doctor or pharmacist for timely treatment.

Handling: Use conventional measures to remove the removed drugs that have not been absorbed in the gastrointestinal tract. Support support and symptomatic treatment. Hemolysis is negligible in blood concentration (1.7%). There is no specific antidote.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Syrup Rutantop often has unwanted effects (ADR) such as:

Common, ADR> 1/100

Neurological: Drowsy, headache, insomnia, dizziness.

Digestive: Nausea, indigestion

Neurological: Fear, sleep disorders, nightmares.

Digestive: dry mouth, abdominal pain.

Skin: Ban, urticaria, itching.

The unwanted effect of the drug is usually mild, only 2.2% of patients have to stop the drug due to ADR of the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

syrup rutantop is contraindicated in the following cases:

Hypersensitivity to fexofenadin, terfenadin or any ingredients of the drug.

Caution when using

Safety and effectiveness of drugs in children under 6 months of age has not been identified.

Need to stop Fexofenadin at least 24 - 48 hours before conducting injection antigen tests.

Use fexofenadin to make psoriasis worse.

Be careful and adjust the appropriate dose when taking drugs for people with impaired renal function because the concentration of drug in plasma increases due to half -life elimination. Be careful when taking medicine for the elderly (over 65 years old) often has impaired renal function.

Use drugs for women during pregnancy and lactation

pregnancy:

Because there is no complete research on pregnant women, only fexofenadin is used for pregnant women when the maternal benefits are superior to the risk of the fetus.

breastfeeding period:

It is unclear whether the drug is excreted in milk or not, whether it has not seen the unwanted effect in newborn babies when nursing mothers use fexofenadin, so be cautious when using fexofenadin for breastfeeding women.

Patients with fructose -intolered genetic problems, glucose - Galactose or Sucrase Isomaltase: because in the ingredient with sucrose, it is recommended that patients should not use this drug.

The effect of the drug on the ability to drive and operate machinery

Although Fexofenadin is less drowsy, but still need to be cautious when driving or control of machinery requires alertness.

Drug interaction

erythromycin, ketoconazole increases fexofenadin levels in plasma but does not change the QT range.

Fexofenadin concentration may be increased by erythromycin, ketoconazole, verapamil, p-glycoprotein inhibitors.

Do not simultaneously use fexofenadin with antacids containing aluminum, magnesi because it will reduce the absorption of fexofenadin. These drugs should be used for about 2 hours apart.

Fexofenadin may increase alcohol concentration, central nervous sedatives, anti -cholinergic substances.

Fexofenadin may reduce the concentration of acetylcholininininiserase inhibitors (in the central nervous system), Betahistin.

Fexofenadin may be reduced by concentrations by acetylcholinininininiserase inhibitors (central nervous system), amphetamine, acid resistant, grapefruit juice, rifampin.

Cavalry

Fruit juice (oranges, grapefruit, apples) can reduce the bioavailability of fexofenadin to 36%.

Avoid using fexofenadin with alcohol because it increases the risk of sedation (sleep).

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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