Siro Theralene Sanofi Treatment of insomnia, rhinitis (90ml)

Dosage form Syrup
Specifications Bottle x 90ml
Ingredient Alimemazine
Indication Rhinitis, dry cough, urticaria, allergic conjunctivitis, insomnia
Contraindication Prostatitis, drug allergies, glaucoma glaules, granulocytes

Ingredient

Composition information	Content
Alimemazine	0.045

Uses

indications

Theralene 90 ml drug is indicated in the following cases:

In case of sometimes insomnia (for example, when traveling far) and/or transient (for example, when there is an emotional event).

In the treatment of symptoms of allergies such as rhinitis (for example: seasonal allergic rhinitis, seasonal allergic, etc.), hives.

Pharmacology

Alimemazine is a phenothiazine derivative, which has antihistamine and strong serotonine resistance, the drug also has sedative effects, cough reduction, anti -vomiting.

characterized by:

Alimemazine competes with histamines at H1 histamine receptors, thus has anti -histamine H1.

A clear sedative effect in the common dose due to histaminergic and Central Adrenolytic effects.

A anti -cholin effect causing peripheral side effects.

A peripheral adrenolytic effect can affect hemodynamics.

Through competitive antagonism mechanism that can be reversed at different levels, all antihistamine drugs have the same ability to fight against the effects of histamine, especially on the skin, bronchial, intestinal and blood vessels.

pharmacokinetics

Alimemazine is quickly absorbed through the gastrointestinal tract. After taking 15-20 minutes, the drug works and lasts 6-8 hours. Alimemazine concentration in plasma is maximum after 3.5 hours.

Half of life is 5-8 hours. Linking with plasma proteins is 20-30%. Large distribution volume by fat solubility of these substances.

Alimemazine metabolizes the liver mainly into N-Desalkyl metabolites with unknown activity and elimination through the kidneys in the form of sulfoxyd metabolites (70-80%, after 48 hours).

In general, the common feature of all antihistamines, and especially phenothiazin, can be mentioned:

Birth is usually not high.

capable of strong metabolism in some cases with the formation of many metabolites, thus explaining why a small amount of drugs found in urine in the form of unchanged.

Before taking Siro Theralene Sanofi Treatment of insomnia, rhinitis (90ml)

How to use

Take oral use.

Take time to take medicine: Because the drug has the effect of drowsiness, it is best to start treating allergies in the evening.

Treatment time: Short -term symptoms should only be treated (a few days).

Dosage

for adults and children over 36 months old:

The dose is calculated according to the amount of alimemazine tartrate, if converted into alimemazine; 1.25 mg Alimemazine Tartrate is equivalent to about 1.0 mg of Alimemazine.

Adults: The maximum dose of 10 mg is equivalent to 16 ml at a time and 40 mg/24 hours, equivalent to 64 ml/24 hours.

Children from 3 years old: 0.125 - 0.25 mg/kg each oral oral equivalent to 0.2 - 0.4 ml/kg at a time, up to 5 mg, equivalent to 8 ml at a time and 20 mg/24 hours, equivalent to 32 ml/24 hours.

Antihistamine: allergic rhinitis, urticaria:

Adults: 10 mg each is equivalent to 16 ml, 2-3 times/day; Up to 100 mg equivalent to 160 ml per day for necessary cases.

Elderly people: reduce the dose to 10 mg equivalent to 16 ml, 1-2 times/day.

Children over 3 years: 2.5 to 5 mg, equivalent to 4 - 8 ml, 3-4 times/day.

In case of sometimes insomnia (for example, when traveling far) and/or fleeting (for example, when there is an emotional event): drink once at bedtime.

Adults: 5 to 20 mg, or 8 to 32 ml.

Children over 3 years old: 0.25 to 0.5 mg/kg or 0.4 to 0.8 ml/kg.

The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? If detected early (before 6 hours, after overdose), it is best to wash the stomach.

The method of vomiting is almost not used. Can use activated carbon. There is no specific antidote, supportive treatment, symptomatic treatment, clinical monitoring and systemic symptoms.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using 90 ml drugs, you may experience unwanted effects (ADR).

Rare, ADR

Blood: Losing leukocytes, leukopenia.

circulating: lowering blood pressure, increasing heart rate. liver: jaundice of jaundice due to cholestasis Neurological: Symptoms of foreign tower, Parkinson's disease, restlessness, acute muscle disorders, late dysfunction, dry mouth can harm teeth and enamel, phenothiazine can reduce seizures threshold in epilepsy.

Respiratory: The risk of respiratory arrest, even causing death suddenly encountered in young children.

Instructions on how to handle ADR

Foreign tower reaction:

Mechanical tone: Most patients with muscle tone disorders respond quickly to treatment with anti -Parkinson anti -cholinergic drugs.

Standing standing still: It can be controlled by a decrease in the dose or simultaneously used a anti -Parkinson anti -cholinergic drug, a benzodiazepine or propranolol.

Parkinson symptoms: usually controlled using combination of anti -Parkinson anti -cholinergic drugs.

Neuroleptic malignant syndrome: stop phenothiazin immediately, symptomatic treatment and support treatment, adjust water and electrolytes, keep cool for patients and maintain kidney function, stabilize blood pressure, prevent respiratory complications. There is currently no special medicine for this syndrome.

Hematology effects: Need to periodically evaluate hematology for long -term phenothiazin patients. If there are signs or symptoms of hematopoietic disorders should stop taking the drug immediately.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Theralene 90 ml drug contraindicated in the following cases:

History of allergies to antihistamine;

Children under 36 months;

Children are dehydrated;

People with liver or kidney dysfunction, epilepsy, Parkinson's disease, hypothyroidism, adrenal marrow tumor, myasthenia gravis;

History of grain leukemia (significantly reducing the number of leukocytes in the blood) with other phenothiazin;

Difficult to urinate due to prostate causes or other causes (prostate hypertrophy);

Some narrow -angle glaucoma (glaucoma);

Patients have used a large amount of central neuronal tranquility.

Be cautious when used

Do not use alcoholic or alcoholic drinks during treatment.

Should avoid sunlight during treatment.

There is a risk of standing syndrome in children.

Consult your doctor in the case:

There is chronic liver or kidney disease.

There is a history of convulsions or epilepsy from before or newly developed.

Having severe heart disease, Alimemazine can cause tachycardia due to the lowering effect of phenothiazine.

There is asthma, stomach ulcers or pyloric inflammation. Family history has sudden death syndrome in infants.

Be cautious when used for children with a history of sleep apnea.

on the elderly: constipation, dizziness or dozing off, prostate disorders. Precautions used in the elderly due to the risk of unwanted effects. Should start treatment at lower dose.

Older people with a deficiency of blood volume will have a hypotension.

The risk of intestinal paralysis in older patients with prolonged constipation.

In case of diabetes or diet reduces powder (abstinence), should pay attention to the content of saccharose (7.1 g in 10 ml of syrup).

The ability to drive and operate machinery

should pay attention to the possibility of drowsiness when taking this medication, especially for drivers and machinery operators. This phenomenon increases when using alcoholic drinks. It is best to start treating allergies in the evening.

Pregnancy

should not take this medicine for the first three months of pregnancy.

Can take the drug in the three months or the last three months of pregnancy, provided that it is only used in a short time (a few days) and with the recommended dose.

However, at the end of pregnancy, if this drug is abused, it can lead to adverse effects on babies. Therefore, always consult a doctor before taking the drug and never be overdosed.

The period of breastfeeding

This drug is very easy to produce breast milk. Because the drug is sedative, can affect children (sleep, reduce tone) or on the contrary, irritation (insomnia), should not use this drug in the case of breastfeeding.

Drug interaction

Do not use:

Alcohol: Alcohol increases the sedative effects of antihistamine drugs. The disadvantage on alertness can be dangerous when driving and using machinery. Avoid using alcoholic drinks and alcoholic drugs.

Due to the alcohol composition in the drug (380 mg in 10 ml of syrup), avoiding use with drugs that cause disulfiram reaction with alcohol such as cefamandol, cefoperazone, latamoxel, chloramphenicol, chlorpropamide, glibenclamide, glipizide, tolbutamide, griseofutrazide, metronidaz Ornidazole, secnidazole, Tinidazole, Ketoconazole, Procarbazine.

Sultopride: The risk of ventricular arrhythmia, especially torsion, due to the drug with physiological effects.

The coordinates need to consider:

Other central nervous system inhibitors (antidepressants have sedative effects, barbiturat, benzodiazepin, clonidine) and substances, sleeping pills, morphine derivatives (analgesic and cough), methadone, neurolithic drugs, anxiety antidote: enhance central neurological inhibition. Respiratory inhibition also occurred when used in combination with these drugs.

The hypotension effect of anti-hypertension drugs, especially the alpha-adrenergic receptor blockers increased when used in combination with phenothiazine derivatives.

Atropine and other substances are active like Atropin (antidepressants, imipramin, anti -cholin, anti -spasms, discopyramid, nerve drugs of Phenothiazine): Increased irregular effect type such as urinary tract, constipation, dry mouth, hotThis.

anti -cholinergic drugs can reduce the anti -psychotic effect of phenothiazin.

Phenothiazine antagonists with therapeutic effects of amphetamine, levodopa, clonidin, guanethidin, epinephrin.

Some drugs that prevent the absorption of phenothiazin are antacids, Parkinson, Lithi medications. high doses of Alimemazine reduces response to hypoglycemic agents.
Adrenalin is not used in patients with overdose phenothiazin.

Storage

Store at a temperature not exceeding 30 ° C, avoiding light.

Other drugs

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