Siro Tylenol Janssen relieves pain and fever for children (60ml)

Dosage form Chaos
Specifications Box x 60ml
Ingredient Acetaminophen

Ingredient

Composition information	Content
Acetaminophen	80mg

Uses

indications

Tylenol drug is indicated in the following cases:

Treatment of temporary pain relief from mild to medium pain in many stits related to musculoskeletal pain, as well as other pain conditions such as headaches (including migraine from mild to medium and muscle tension), ear pain, back pain, arthritis pain, dysmenorrhea, muscle pain and nerve pain.

Treatment of reduced fever symptoms caused by common colds, influenza and other viral or bacterial infections.

Pharmacokinus

paracetamol is an analgesic - antipyretic but not effective for inflammation treatment. Paracetamol reduces the body temperature of the patient, but rarely reduces the body temperature in normal people. The drug acts on the hypothalamus, causing cooling off, increasing heat due to vasodilation and increased peripheral blood flow.

Paracetamol with a low dosage that affects the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding like when using salicylate, because paracetamol only affects cyclooxygenase/prostaglandin of the central nervous system. Paracetamol does not work on platelets or bleeding time.

pharmacokinetics

absorption:

Paracetamol is quickly absorbed and almost completely through the gastrointestinal tract. Carbon hydrate -rich foods reduce the absorption rate of paracetamol.

Distribution:

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Metabolism:

Paracetamol complex in the liver with glucuronic acid (about 60%), sulfuric acid (about 35%), or cysteine (about 3%), also detected a small amount of hydroxyl metabolites - chemicals and reducing acetyl.

Era:

The half -life of paracetamol plasma is 1.253 hours, can be prolonged with toxic doses or in patients with liver lesions.

Before taking Siro Tylenol Janssen relieves pain and fever for children (60ml)

How to use

Take oral use.

The drug can be used or not with the same food (for example, milk, formula milk, juice, ...).

Each 2.5ml of medicine (1/2 teaspoon) contains 80mg of acetaminophen (paracetamol).

Dosage

Children under 12 years:

Weight (kg) Age group Single dose (mg)

2.5 - 5.4

0 - 3 months 40 5.5 - 7.9 Month 80 Age 240 Age 480 There is no data for appropriate dose adjustment, if needed in the initial neonatal stage. Using antipyretic drugs in this period is very limited. What to do when overdose? The clinical progress of paracetamol overdose usually occurs in a three -stage progress.

The first phase starts right after drinking and lasts for 12 to 24 hours. Patients may show signs of gastrointestinal irritation, nausea, vomiting, appetite, sweating, pale and body fatigue.

If the toxicity continues, there is a hidden period of up to 48 hours. In this second phase, the initial symptoms will decrease and the patient may feel better. However, liver enzymes, bilirubin and prothrombin or Inr values will gradually increase. Pain below the right flank may appear when the liver becomes enlarged and soft. Most patients do not progress to this stage, especially if N-acetylcysteine (NAC) is treated early in the early stages.

Signs and symptoms of the third phase depend on the severity of liver damage and usually occur from three to five days after overdose.

General treatment: When Paracetamol's overdose is likely to start the treatment immediately and include the digestive tract detoxification, appropriate support care, careful assessment of the serum paracetamol concentration on time is evaluated on Rumack-Matthew Maths, timely use of NAC on demand and appropriate monitoring care.

Liver function tests should be done initially and repeated with a distance of 24 hours.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose

Side Effects

When using Tylenol , you may experience unwanted effects (ADR).

Uncommon, 1/1000

Skin and subcutaneous tissue: Skin reaction (usually erythema, rash, itching, urticaria, sometimes worse and may be accompanied by fever due to drugs and mucosal lesions).

Digestive: Nausea, vomiting.

Other disorders: Hemorrhagic disorders (neutropenia, hypoglycemia, thrombocytopenia), Anemia , kidney disease, kidney toxicity when abused for a long time.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tylenol drugs contraindicated in the following cases:

Hypersensitivity to paracetamol or any component in the formula.

Not used with any other products containing paracetamol.

Patients with glucose-6-phosphate dehydrogenase deficiency.

Caution when using

General warning:

Adults and children aged 12 years and older must not use paracetamol more than 4 g/day or use many products containing paracetamol at the same time. Children under 12 years of age should not take more daily daily dose.

On the liver:

At the current recommended dose Paracetamol is an appropriate pain relief option for use in patients with chronic stable liver disease when used under the supervision of a doctor. Paracetamol can be toxic to the liver in intentional overdose situations (such as suicide), an overdose of unintentional (for example, overdose when an analgesic effect is not sufficient).

Use chronic alcohol:

Excessive alcohol use may increase the risk of liver toxicity due to paracetamol overdose.

on the kidney:

can use paracetamol in patients with chronic kidney disease without adjusting the dose. Do not encourage the use of Paracetamol regularly.

On the skin:

Doctors should warn patients on signs of serious skin reactions such as Steven-Johnson syndrome (SJS), poisoned epidermal necrotic syndrome (Ten) or Lyell syndrome, acute all-body pustular syndrome (AGEP).

The ability to drive and operate machinery

negligible effects.

Pregnancy

There is no adequate clinical research and good control in pregnant women. Used only when benefits are significantly greater than the risk of the fetus.

The period of breastfeeding

There is no adequate clinical research and good control in breastfeeding women. Be careful when used in this patient.

Interactive drug

Painkillers: Used with paracetamol may increase adverse events (for example, kidney toxicity, digestive tract damage, bleeding).

Alcohol: Used with paracetamol shows some evidence of harmful effects on liver function tests.

Oral anticoagulants: Patients with simultaneous use of Warfarin and Paracetamol -type anticoagulants are sometimes reported that the Inr increase is not expected.

Anti -seizure drugs: Some reports have suggested that patients who are taking anti -convulsions long -term and paracetamol overdose, which may increase the risk of liver toxicity due to paracetamol metabolism.

Hytantoin: In the normal oral treatment of Paracetamol and Hytantoin, often do not need to adjust the dose or special monitoring.

Carbamazepine: In the normal oral treatment of Paracetamol and Carbamazepine, often do not need to adjust the special dosage.

diflunisal: Caution should be careful when using Diflunisal with paracetamol simultaneously and patients should be carefully monitored.

Isoniazid: Some reports show that patients with chronic isoniazid treatment may be at risk of liver toxicity due to paracetamol overdose.

Storage

Storage below 30 ° C.

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