Small eye solution Timolol Maleate Eye Drops 0.5% Alcon Label treatment (5ml)

Chronic open -angle glaucoma

Secondary glaucoma

Pharmacy

Pharmacological group: Tabula and pupils, selective beta blockers.

Mechanism of action

Timolol Maleatate Eye Drops 0.5% is a beta receptor blockers, and beta 2 (not selected) with eye small eyes. The mechanism of glaucoma effects of beta blockers is unknown, but by the method of labeling and measuring fluorescent, it is found that this drug reduces the production of aquaculture.

In addition, in some studies, observations showed a slight increase in the flow of aquatic fluid. Timolol reduces glaucoma but few or no regulating effects.

The low-glaucoma effect of Timolol Maleatate Eye Drops 0.5% quickly, appears about 20 minutes after the eye drops and reaches a maximum within 1-2 hours. Small small eye solution Timolol Maleate Eye Drops 0.5% can be effectively maintained within 24 hours.

Dynamic pharmacokinetics

It is possible to see the onset effect that reduces the internal pressure within half an hour after the single dose. The maximum effect appears within 1 or 2 hours; The significant effect of reducing glaucoma can be maintained within 24 hours with a single dose.

Pediatric patients: Similar to adult research data, 80% of the eye drops will flow through the nasal glands that can be quickly absorbed into the circulatory system through the nasal mucosa, nasal, pleura pipes, pleura and skin from tears.

Due to the volume of circulatory in children smaller in adults, it is necessary to consider having a higher level of drug circulation in children. Moreover, enzyme metabolism in newborns is incomplete and can lead to increased semi -discharged time and adverse reactions.

Glucagon: Starting treatment with 1-10 mg intravenously, then continuous transmission 2-2.5 mg/hour.

What to do when you forget a dose? However, if it is close to the next dose, skip the forgotten dose and return to your normal medication schedule.

Diseases that affect the airway including bronchial asthma or a history of bronchial asthma, chronic obstructive pulmonary disease.

Sinus slow pace, sinus node impairment syndrome, atrial sinus block, atrial atrial block of level 2 or degree 3, clear heart failure or heart shock.

Be cautious when using

It is necessary to carefully evaluate the use of beta blockers to treat in patients with cardiovascular disease (such as coronary artery disease, prinzmetal angina, heart failure) and lower blood pressure and should consider using other replacement drugs. Patients with cardiovascular disease should be wary of worse signs of these diseases and unwanted effects.

Be cautious when used for patients with peripheral circulatory disorders (Raynaud or severe raynaud syndrome).

There have been reports on respiratory reactions, including death from bronchospasm in patients with asthma after using a few small eye -small ophthalmic blocks.

Because beta blockers can cover the symptoms of acute hypoglycemia, be cautious when using beta blockers for patients with spontaneous hypoglycemia or unstable diabetes patients.

Beta blockers can cover the symptoms of hyperthyroidism.

Beta blockers have been reported to have a muscle weakness with some obvious symptoms (such as a song, eyelash collapse and body weakness).

While treating with beta blockers, patients with a history of allergies or a history of serious anaphylaxis with many allergens that responds more strongly when exposed to those allergens and they do not respond to conventional adrenalin doses used in emergency anaphylactic reactions.

There has been a report on the effect of causing peeling when treated with aquatic drugs (such as Timolol or Acetazolamid) after raft surgery.

Small beta blockers can inhibit the systemic effects of beta -agonized agents like Adrenalin. It is necessary to notify the anesthetic doctor when the patient is using Timolol.

benzalkonium chloride can cause irritation and change the color of soft contact lenses. Should avoid contact with soft contact lenses. It is necessary to guide patients to remove contact lenses before taking Timolol Maleate eye Drops eye drops 0.5% and wait at least 15 minutes before wearing glasses.

The ability to drive and operate machinery

temporary blurred vision or vision disorders may affect the ability to drive and operate machinery. If the patient looks blurred after small eyes, it is necessary to wait until it is clear and then continue to drive or operate machinery.

Pregnancy

Not enough data on the use of Timolol Maleate small eye solution for pregnant women. Epidemiological studies do not show the likelihood of fetal malformations but also show the risk of endometria retardation when treated with oral beta blockers.

Besides, there were signs and symptoms of beta blockers in infants when the mother used beta blockers until birth.

Do not use Timolol Maleatate small eye solution during pregnancy, unless it is really necessary. However, if the mother has to be treated with a small Timolol Maleate eye solution during pregnancy, it is necessary to closely monitor babies in the early days of postpartum.

Breastfeeding period

Beta blockers are excreted into breast milk that can cause many unwanted effects to breastfeed.

To prevent serious unwanted effects that may occur with breastfeeding, the amount of benefits of breastfeeding with babies and the benefits of mothers treatment to decide should stop breastfeeding or stop or avoid using Timolol Maleate eye.

Drug interaction

There has been a report on the risk of increasing the effect of beta blockers (such as slow heart rate, depression) when using CYP2D6 breasts simultaneously (such as quinidin, fluoxetin, paroxetin) with Timolol.

Simultaneous use of small eye solution contains active ingredients beta with oral calcium channel blockers, other beta blockers, anti -arrhythmic drugs (including amiodaron), glycosides of cardiac support or fake sympathetic drugs that can cause side effects such as lowering blood pressure and/or significant slow heart rate.

There has been a report that occasionally relaxes from the same time as simultaneously small beta blockers with adrenalin (epinephrin).

Me: increases the risk of cardiovascular collapse and hypotension due to inhibition of the heart's response to sympathetic stimulation reflexes.

cimetidine, hydralazin, phenothiazin and alcohol may increase the concentration of Timolol in the blood.