Smart-Air 10mg Abbott medicine for chronic bronchial asthma (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Montelukast

Ingredient

Composition information	Content
Montelukast	10mg

Uses

Indications

Smart Air 10 is indicated for adults in the following case:

Preventive and treat chronic bronchial asthma in adults and children greater than 2 years old. Cysteinyl - Leukotriene CYSLT1. Cysteinyl - Leukotriene (LTC4, LTD4, LTE4) is the result of arachidonic acid metabolism released from several cells such as moisturizers and EOSIN -preferred cells, they combined with cysteinyl - leukotriene receptor on the air pathway. The combination of cysteinyl - Leukotriene with receptor related to asthma pathology, including edema in the air pathway, smooth muscle contraction and replaces the active cells of the anti -inflammatory process, these factors cause symptoms of asthma. Montelukast has a great affinity and selective with CYSLT1 receptor (associated with other receptors on the Prostanoide, Cholinergic or β -ADRENERGIC), inhibiting the activity of Cysteinyl - Leukotriene Ltd4 through these substances without effect on the host.

pharmacokinetic

Montelukast absorbs quickly through oral and placed under the tongue, the peak concentration in the serum reaches 3-4 hours after taking the medication, and 2 - 2.5 hours after placing under the tongue. The maximum serum concentration is not affected by food in the gastrointestinal tract in the morning despite bioavailability, in case of under the tongue can increase when the stomach is empty.

Montelukast is strongly linked to serum protein and the distribution integral in a sustainable state of 8 - 11 liters.

The effect of the drug lasts for 24 hours and does not increase asthma when stopping treatment after 12 weeks.

Before taking Smart-Air 10mg Abbott medicine for chronic bronchial asthma (1 blister x 10 tablets)

How to use

Take oral use.

The drug is taken once a day. Prophylaxis and treatment of asthma should take medicine in the evening. Treatment of allergic rhinitis, drug use time depending on the needs of each object.

For patients with both asthma and allergic rhinitis, they should take a dose every day in the evening.

Dosage

adults and children> 15 years old: 1 tablet 1 tablet daily.

Children from 6 - 14 years old: Day 1 tablet 5 mg.

Children from 2 - 6 years old: 1 tablet 4 mg.

What to do when overdose? The most common reactions include abdominal pain, drowsiness, thirst, headache, vomiting and agitation. There is no Montelukast research that can be separated through the peritoneal or dialysis.

What to do when forgetting a dose?

Continue to dose the normal treatment. Do not use double dose to compensate for missed dose.

Side Effects

Side effects to note include:

rarely

Increased liver enzyme.

Rare

latex.Common

Headache.

Less

Abdominal or stomach pain, weakness, fatigue, cough, toothache, weakness, indigestion, fever, gastrointestinal tract infection, nasal congestion and skin changes. Patients use Leukotriene like Montelukast, Pranlukast and Zafirlukast but very rare. In most cases, symptoms related to oral corticosteroid or taken stops.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Smart Air 10 drugs contraindicated in the following cases:

Do not take medicine for patients with a history of hypersensitivity to Montelukast or one of the ingredients of the drug.

Precautions when using

Precautions when indicating Smart Air for the following patients:

Pediatrics: Safe and effective use of drugs for children under 2 years of age has not been set up, not using these drugs.

Other: Using medium -sized medication patients with moderate to medium to medium as well as patients with clinical manifestations of chronic liver disease must be evaluated due to Montelukast's excreted half -life that may increase (on average 7.4 hours). However, in some cases, the dose is no need to adjust. Do not use Montelukast for patients with severe liver failure.

The ability to drive and operate machinery

The drug can cause drowsiness, do not use drugs for people who are driving or operating machinery.

Pregnancy

There is no sufficient research on human use, so it is necessary to consider the benefits and risks for the fetus before using Montelukast.

Breastfeeding period

Unknown excretion of Montelukast through breast milk. Be cautious when using the drug for this object.

Drug interaction

Montelukast has been used with other common medications in the room and treating asthma for a long time without side effects. In addition, the drug has been used in combination with benzodiazepine, anti -stuffy drugs, nonsteroidal anti -inflammatory drugs, sleeping pills, sedatives and thyroid hormones without increasing side effects.

In studies on drug interaction with normal doses Montelukast does not significantly affect the pharmacokinetics of theophyllline, warfarin, terfenadine, digoxin, oral contraceptives, prednison, prednisolin.

Montelukast is metabolized by Cytochrom P450 3A4 and 2C9, induction or inhibitors of this enzyme system (such as erythromycin, ketoconazol, or fluconaol) may affect Montelukast serum concentration.

Phenobarbital is a strong Cytochrom P450 induction, when used simultaneously reduces the area under the curve of Montelukast 40%, so patients use these strong enzyme induction drugs to re -assess clinical response and/or side effects.

Storage

A cool dry place, under 30 ° C, avoid light.

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