Sodium bicarbonate transmission 1.4% Fresenius Kabi to treat urine alkalinization (500ml)

Dosage form Bottle x 500ml
Specifications Sodium bicarbonate

Ingredient

Composition information	Content
Sodium bicarbonate	1.4g

Uses

Indications

1.4% sodium bicarbonate drugs are indicated in the following cases:

Adjust metabolic acidosis.

alkaline urine in the case of poisoning phenobarbital.

Pharmacy

Sodium bicarbonate is an important role in the buffer system of the extracellular compartment. Alkaline effects occur quickly. Sodium bicarbonate solution, which is effective when the pulmonary ventilation is not damaged, because the cushion effect increases the release of carbon dioxid. Sodium bicarbonate transmission causes rapid alkaline effect in case of metabolic acid infection, lactic acid infection or in case of alkaline.

pharmacokinetic

After sodium bicarbonate intravenous infusion, instant effects occur. Treatment of metabolic acid infections must not be too fast. Only half of the treatment should be started and then rely on blood analysis to continue treating later.

Before taking Sodium bicarbonate transmission 1.4% Fresenius Kabi to treat urine alkalinization (500ml)

How to use

slow intravenous infusion.

The solution must be transmitted to the central vein.

Dosage

Dosage depends on the degree of acid-base imbalance.

Metabolic acidosis

Used for adults and children

According to arterial blood gas, age, weight, condition, dosage will be calculated by the following formula:

Sodium bicarbonate (mmol) dosage = Base deficiency (mmol/l) x weight (kg) x 0.3 (coefficient 0.3 corresponds to the correlation rate of extracellular fluid compared to the total amount of body fluid).

For example: If the base deficiency in patients weighs 70kg is 5mmol/l then: 5 x 70 x 0.3 = 105mmol sodium bicarbonate is transmitted (corresponding to 630ml of 1.4%sodium bicarbonate solution).

If the arterial blood is not tested (ABGS), then by experience treatment, slow infusion into the vein at first 1mmol/kg, then after 10 minutes use no more than 0.5mmol/kg.

Used for babies

In newborns, the daily dose must not exceed 8mmol/kg body weight/day, used by slow intravenous infusion.

The adjustment of metabolic acidosis should not be done too quickly. It is recommended to use half of the calculated dose and continue to adjust the dose according to the actual gas analysis results.

Maximum daily dose: according to adjustment requirements.

Urine alkalinization

To alkaline urine, the dose is adjusted according to the desired pH of the urine and should be accompanied by acid-base balance monitoring and water balance.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

When overdose should stop infusion. To control the symptoms of alkaline infection, patients should breathe by inhaling the exhaled air, or if worse can be injected with intravenous sodium chloride solution 0.9%.

In case of hypokalemia, potassium chloride may be used. If in patients with muscle spasms that cannot be controlled by breathing out of air, may need calcium gluconate.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using 1.4%sodium bicarbonate, you may experience unwanted effects (ADR).

Metabolic and nutritious disorders: alkaline infection, hypokalemia, hyperemia, osmotic hypertension, hypocc calcium, hypoglycemia, acidosis in paradoxic cells.

Heart disorders: impaired hemodynamics combined with circulatory overload.

Nervous system disorders: intracranial hemorrhage (in newborns), prone to irritation, or spasticity.

Common disorders and at the infusion site: exit. Improper transmission (veins, arteries) can cause tissue necrosis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

1.4% Sodium Bicarbonate drugs in the following cases:

Respiratory alkaline infection and metabolic alkaline infection.

Reduce ventilation.

Hypercodia hyperka.

In situations where sodium injection is contraindicated such as: heart failure, edema, hypertension, eclampsia, kidney damage.

Lower blood calcium.

Lost chloride.

hyperlink blood.

Renal failure.

There is a history of urinary stones.

Precautions when using

Pay special attention to the ability to reduce potassium potassium.

If the supply of sodium is contraindicated, but the kidney function is not damaged, it is advisable to alkaline with tromethamine solution.

The risk of hyperchemical hyperemia and increased osmotic in patients with heart failure and kidney failure, then leads to the risk of increased blood and pulmonary edema. Especially in patients with little kidney failure, urinary retention and patients who are using corticosteroids.

During the treatment of acid infection with sodium bicarbonate, electrolytes and base acid balance are required.

Whenever transmitting sodium bicarbonate solution, arterial blood parameters, especially hyperactivity/veins and carbon dioxid levels must be tested in advance and during the treatment process to minimize the possibility of overdose and cause alkaline infection.

An accident due to extracellular injection of hypertonic solutions can cause vascular irritation or scales. Avoid use on scalp veins.

If respiratory acidosis is combined with metabolic acidosis, lung ventilation and infusion must be used to avoid excess CO2.

For babies and children ( 8mmol/kg body weight/day.

The ability to drive and operate machinery

No report.

Pregnancy

has not determined the safety when transmitting sodium bicarbonate to pregnant women. However, it is necessary to avoid being used when being shocked.

Breastfeeding period

Not determined safety when transmitting sodium bicarbonate to breastfeeding people. Consider the benefits compared to the risk when used in nursing women.

Medicinal interaction

Urine alkalization will increase the excretion in the kidneys of acids, for example: tetracyclin, doxycyclin, acetylsalicylic acid, chlorpropamide, lithium, methenamide. It increases the selling time and the time of basic drugs such as quinidine, amphetamine, ephedrin, pseudoephedrin, memantin and flecainid. Sodium bicarbonate can increase the reabsorption in the diameter of mecamylamine causing hypotension.

Avoid using sodium bicarbonate with alcohol.

Be cautious when using sodium ions for patients who are taking corticosteroids or corticotropin.

Alkaline infection with chloride may occur if used in combination with sodium bicarbonate with potassium diuretic such as bumetanid, ethacrynic acid, furosemid and thiazid.

Simultaneous use of sodium bicarbonate in patients who are taking potassium supplements can reduce blood potassium concentration by promoting intracellular ionic movement.

Storage

The temperature does not exceed 30 ° C, avoiding light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.