Sodium bicarbonate transmission 1.4% Fresenius Kabi Treatment of metabolic acidosis (500ml)

Dosage form Bottle x 500ml
Specifications Sodium bicarbonate

Ingredient

Composition information	Content
Sodium bicarbonate	7

Uses

Indications

1.4% sodium bicarbonate drugs are indicated in the following cases:

Treatment of metabolic acidosis. Alkaline effects occur quickly. Sodium bicarbonate solution is effective when the pulmonary ventilation does not hurt because of the cushion effect that increases the release of carbon dioxide. Sodium bicarbonate transmission causes rapid alkaline effect in case of metabolic acid infection, acidic contamination caused by lactic acid or in case of alkaline.

pharmacokinetic

After sodium bicarbonate intravenous infusion, alkaline effects occur instantly. Treatment of metabolic acid infections must not be too fast. Only half of the dose should be started and then based on arterial blood analysis to continue treating later.

Before taking Sodium bicarbonate transmission 1.4% Fresenius Kabi Treatment of metabolic acidosis (500ml)

How to use

Slow intravenous infusion.

The solution must be transmitted to the central vein.

Dosage

Dosage depends on the degree of acid imbalance - base.

Treatment of metabolic acidosis

Used for adults and children

According to arterial blood gas, age, weight, condition, dosage will be calculated by the following formula:

Sodium bicarbonate (mmol) = Base deficiency (mmol/l) x weight (kg) x 0.3 (coefficient 0.3 corresponds to the correlation ratio of extracellular fluid compared to the total amount of body fluid).

For example

5 x 70 x 0.3 = 105 mmol sodium bicarbonate is transmitted (corresponding to 630 ml of 1.4% sodium bicarbonate solution (volume/volume)).

If the arterial blood test (ABGS) cannot be tested, according to the treatment, slow infusion into the vein at first 1 mmol/kg, after 10 minutes use no more than 0.5 mmol/kg.

Used for babies

In newborns, daily dose must not exceed 8 mmol/kg body weight/day, used by slow intravenous infusion.

The adjustment of metabolic acidosis should not be done too quickly. It is recommended that only half of the calculation dose should be used and continue to adjust the dose according to the results of blood gas analysis in the blood.

Maximum daily dose: according to adjustment requirements.

Urine alkaline

To alkalize urine, the dose is adjusted according to the desired pH of the urine and should be accompanied by acid -base balance monitoring and water balance.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? To control the symptoms of alkaline infection, patients should breathe by inhaling the exhaled air, or if worse can be injected with intravenous infusion of 0.9%sodium chloride solution. In case of hypokalemia, potassium chloride may be used. If the patient appears muscle spasms that cannot be controlled by breathing out the air out, may need calcium gluconate.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using 1.4%sodium bicarbonate, you may experience unwanted effects (ADR).

Metabolism and nutrition: alkaline infection, hypokalemia, hyperkemia, osmotic hypertension, hypocc calcium, hypoglycemia.

Heart disorders: impaired hemodynamics combined with circulatory overload.

Neurological: intracranial hemorrhage (in newborns), prone to stimulation, muscle spasms.

Common disorders and at the infusion site: escape, incorrect transmission (near veins, arteries) can cause tissue necrosis.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

1.4% Sodium Bicarbonate drugs in the following cases:

Respiratory alkaline infection, metabolic alkaline infection.

Air reduction.

Hypercodia, lowering blood calcium, loss of chloride.

Cases where sodium injection is contraindicated such as heart failure, edema, hypertension, and kidney damage.

hyperlemen blood.

kidney failure.

There is a history of urinary stones.

Precautions when using

Pay special attention to the ability to reduce potassium potassium.

If the supply of sodium is contraindicated but the kidney function is not damaged, it is advisable to alkaline with Tromethamine solution.

The risk of hyperchemical sodium and increased osmotic in patients with heart failure and kidney failure, leading to the risk of increased blood and pulmonary volume. Especially in patients with little kidney failure, urinary retention and patients who are using corticosteroids.

During the treatment of acidic infection with sodium bicarbonate, electrolytes and acid - base balance are required.

Whenever transmitting sodium bicarbonate solution, arterial blood parameters, especially hyperactivity/veins and carbon dioxide levels must be tested in advance and during the treatment process to minimize the possibility of overdose and cause alkaline infection.

External injection of hypertonic solutions can cause strong irritation or scales. Avoid use on scalp veins.

If respiratory acidosis is combined with metabolic acidosis, pulmonary ventilation and infusion must be used to avoid excess CO2.

For babies and children ( Do not use> 8 mmol/kg body weight/day.

The ability to drive and operate machinery

No report.

Pregnancy

has not determined the safety when transmitting sodium bicarbonate to pregnant people. However, it is necessary to avoid being used when the product is shocked.

Consider the benefits compared to the risk when used in pregnant women.

Breastfeeding period

Unknown safety when transmitting sodium bicarbonate to breastfeeding people.

Consider the benefits compared to the risk when used in nursing women.

Medicinal interaction

The alkalinization of urine will increase the excretion in the kidneys of acids, for example: tetracycline, Doxycycline, acetylsalicylic acid, chlorpropamide, lithium, methenamide. The drug increases the sale time and the time of action of Quinidine, Amphetamine, Ephedrine, Pseudoephedrine, Memantine and Flecainide.

Sodium bicarbonate can increase the reabsorption in the renal tubules Mecamylamine causing hypotension.

Avoid using sodium bicarbonate with alcohol.

Be cautious when using sodium ions for patients who are taking corticosteroids or corticotropine.

Alkaline infection with chloride may occur if used in combination with sodium bicarbonate with potassium -lowered diuretics such as bumetanide, ethacrynic acid, furosemide and thiazide. Simultaneous use of sodium bicarbonate in patients who are taking potassium supplements can reduce blood potassium levels by promoting intracellular ionic movement.

Storage

Store at a temperature not exceeding 30 ° C, avoiding light.

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