Soli-Medon 40 Bidiphar injection powder used anti-inflammatory, immunodeficiency (1 bottle of powder + 1 tube 1ml)

Dosage form Box
Specifications Methylprednisolone

Ingredient

Composition information	Content
Methylprednisolone	40mg

Uses

Indications

Soli Medon 40 medicine is indicated in nausical therapy that requires anti -inflammatory and immunosuppressive effects of methylprednisolon for:

Rheumatoid arthritis, systemic lupus system.

Some forms of vasculitis: temporal arteritis, arterial inflammation.

Sarcoid disease, bronchial asthma, chronic ulcer.

Anemia hemolysis, granulocytosis.

Severe allergies including anaphylaxis.

In cancer treatment: such as acute leukemia, lymphoma, breast cancer and prostate cancer.

Methylprednisolon is also indicated in the treatment of nephropathy syndrome.

Pharmacy

Methylprednisolon is a derivative Glucocorticoid 6 - Alpha - Methyl of Prednisolon, anti -inflammatory, anti -allergic and immune -inhibiting effects. The anti -inflammatory effect of methylprednisolon increases by 20% compared to the effect of Prednisolon. Methylprednisolon takes effect 5 times more hydrocortisone.

Inflammation, whatever the cause is characterized by the escape and absorbent of the white blood cells into the tissue in an inflamed position.

methylprednisolon inhibits these phenomena.

methylprednisolon also inhibits the function of lymphocytes and tissue macrophages. Their response ability with antigens and cockroaches is reduced. The effect of methylprednisolon on special macrophages, limiting their macrophages, limiting the ability to kill microorganisms and limiting the production of Interferon - Gama, Interleukin - 1, fever, collagenase and elastase enzymes, the factor causing necrosis of swelling and glasminogen damage. Methylprednisolon works on lymphocytes to reduce the production of Interleukin - 2.

In addition to the effect on the function of leukemia, methylprednisolon also affects inflammatory reaction by reducing prostaglandin synthesis due to phospholipase activation A2. Methylprednisolon increases the concentration of some membrane phospholipids that inhibit prostaglandin synthesis. Methylprednisolon also increases lipocortin levels, which is a protein that reduces phospholipids, the substrate of A2 phospholipase. Finally, methylprednisolon reduces the appearance of cyclooxygenase in inflammatory cells, thus reducing the amount of enzyme to produce prostaglandin.

methylprednisolon reduces capillary permeability due to inhibition of the activity of kinine and bacterial endotoxins, due to reducing base leukemia hydrogen release.

In some cases, methylprednisolon killes lymphocytes - T, unusual, including some cancer cells. The normal lymphocytes - T in peripheral blood are highly resistant to the cell death of methylprednisolon. Methylprednisolon can cause cell death in the program (apoptosis) in cell lymphocytes, along with some chains of lymphocytes. These anti -lymphocytes are exploited in chemotherapy Leukemia lymphoma and lymph nodes.

In the treatment of bronchial asthma, it is necessary to treat beta stimulants and methylprednisolon injections. In the treatment of severe chronic bronchial asthma that other measures are ineffective, can be used long -term methylprednisolon with the lowest doses that can save the patient's life and need to be cautious when planning to stop the drug.

Methylprednisolon is widely used in the treatment of many different low diseases and is a major measure in the treatment of more severe diseases such as systemic lupus system and many vasculitis such as spot inflammation, WGGER seed tumor and giant cell artery. For these severe disorders, methylprednisolon dose begins to reduce the disease quickly and to minimize tissue lesions, then with the stage also tries with the only daily dose and gradually decreases, to the minimum dosage to work.

In rheumatoid arthritis, the dose begins are relatively low, in the acute phase, the dosage may be higher, then gradually decreases quickly. It is possible to treat people with the main symptoms of the disease in one or a few joints by injecting methylprednisolon in the joints.

In children with chronic arthritis with complications that threaten life, sometimes use methylprednisolon in attacking therapy. Methylprednisolon may be injected in the joints as in adult disease, but in children the typical signs of Cushing syndrome, they osteoporosis, spinning and growth will grow rapidly.

Methylprednisolon works well in some people with chronic colitis and Crohn's disease.

Methylprednisolon is the leading therapy for nephrotic syndrome, in chronic glomerulonephritis, applying methylprednisolon therapy for every day for 8-10 weeks and then reducing the dose gradually for 1-2 months.

Can treat allergies in a short time such as hay sauce, serum, urticaria, contact dermatitis, drug reaction, bee and nerve edema - vascular with methylprednisolon supplements for the main therapy.

In immunodemorrhage anemia, if the main cause is not cured or if methylprednisolon is required, it is a basic therapy, rarely indicating blood transfusion because it can cause hemolytic complications. If the disease is dangerous to life, high -dose intravenous methylprednisolon before blood transfusion and need to monitor the patient.

Sarcoid treatment with methylprednisolon. Due to the risk of secondary tuberculosis, the patient has a manifestation of tuberculosis to treat tuberculosis.

pharmacokinetics

After intravenous injection or intramuscular methylprednisolon sodium sucinat for an hour. The drug is completely excreted within 12 hours. Therefore, to achieve a hybrid dosage treatment concentration every 4-6 hours.

Before taking Soli-Medon 40 Bidiphar injection powder used anti-inflammatory, immunodeficiency (1 bottle of powder + 1 tube 1ml)

How to use

Soli Medon medicine is used for intramuscular (IM)/intravenous injection (IV).

Dosage

Determination of dosage for individuals

The starting dose: 6 - 40 mg/day. The dose is needed to maintain the lower treatment effect than the dose needed to achieve the initial effect. Lowest dose must be determined to achieve the effect of gradually reducing the dose step by step until signs or symptoms increase.

When you need to take large doses for a long time, apply a daily -time drug (use a single dose of methylprednisolon every 2 days in the morning in the pace of methylprednisolon natural time) will be less ADR because there is recovery time between each dose.

Treatment of severe asthma attacks

intravenous injection 60 - 120 mg/ time, every 6 hours of injection.

Treatment of acute asthma attacks

methylprednisolon 32 - 48 mg/day, for 5 days, then additional treatment can be added at lower doses for 1 week. When from acute attacks, methylprednisolon is gradually reduced.

rheumatoid arthritis

During exacerbations, higher doses: 16 - 32 mg/ day, then gradually decreases.

Children's arthritis with life -threatening complications

Using attack therapy, dose of 10 - 30 mg/kg/batch (usually used 3 times).

Nephropathy syndrome

The starting dose of 0.8 - 1.6 mg/kg/day for 6 weeks, then gradually decreases the dose for 6 - 8 weeks.

Heavy allergies in a short time

Intravenous injection 125 mg, every 6 hours of injection.

Immune hemolyticemia

intravenously 1000 mg/day, for 3 days. Must treat at least 6 - 8 weeks.

Before blood transfusions for hemolytic anemia

intravenous injection 1000 mg to prevent complications of hypertension.

Sarcoid disease

0.8 mg/kg/day to improve the disease. Low maintenance dose, 8 mg/day.

Note:

Nethylprednisolon Sodium Sucinat solution after phase is stored at a temperature of 15oC - 30oC and used within 48 hours.

The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

When using too high doses for a long time, increase adrenal gland energy and inhibit the adrenal glands may occur.

In these cases, it is necessary to consider to make the right decision to suspend or stop using methylprednisolon ..

What to do when forgetting a dose?

Side Effects

When using Soli Medon 40, you may experience unwanted effects (ADR).

occurs when using methylprednisolon high and long -term.

Common

Insomnia, nervousness is easily agitated, increased appetite, indigestion, hair, diabetes, joint pain, cataracts, glaucoma, nosebleeds.

rarely

Dizziness, convulsions, mental disorders, fake tumors in the brain, mood changes, delirium, hallucinations, refreshment, edema, hypertension, acne, skin atrophy, bruising, tissue hyperpigmentation, Cushing syndrome, pituitary -suppressing pituitary - adrenal, glucose tolerance, reducing potassium, alkaline infection, stomach, pancreatic ulcer, pancreatic ulcer, pancreat muscle, osteoporosis, fracture.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Soli Medon 40 drug contraindicated in the following cases:

Patients with hypersensitivity to methylprednisolon and the ingredients of the drug.

Severe infections, except for bacterial shock and meningitis.

Viral, mushroom or tuberculosis skin lesions.

is using a living virus vaccine.

Do not use this drug on patients allergic to cow's milk protein.

Caution when using

Use cautiously in patients with osteoporosis, new blood vessel connection, mental disorders, stomach ulcers, duodenum ulcers, diabetes, hypertension, heart failure and adult children.

Due to the risk of unwanted effects, caution must be used with methylprednisolon for the elderly with the lowest dose and in the shortest possible time.

Acute adrenal insufficiency may occur when stopping the drug suddenly after a long time of treatment or when stressed.

When using high doses, it can affect the effect of vaccinations.

No contraindication to methylprednisolon for nursing mothers.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

Extended methylprednisolon for the mother can lead to mitigation of the baby's weight. In general, using methylprednisolon in pregnant women requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child.

Breastfeeding period

No contraindication to methylprednisolon for nursing mothers. However, refer to the doctor before use.

Drug interaction

methylprednisolon is a cytochrom P450 enzyme induction and the substrate of the P450 3A enzyme, so this drug has an impact on the metabolism of ciclosporin, erythromycin, phenobarbital, phenytoin, carbamonepin, ketoconon, ketocony Rifampicin.

Phenobarbital, Phenytoin, Rifampicin and diuretics decreased potassium can reduce the effectiveness of methylprednisolon.

methylprednisolon may cause hyperlemor of blood glucose, so higher insulin dose is needed.

Storage

In a dry place, temperatures below 30˚C, avoid light.

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