Somazina 1000mg injection treatment for cognitive and sensory disorders (5 tubes x 4ml)

Dosage form Box of 1 blister x 5 tubes
Specifications Citicoline

Ingredient

Thành phần cho 4ml

Composition information	Content
Citicoline	1000mg

Uses

Indications

Somazina are indicated for treatment in the following cases:

Acute stroke and neurological sequelae.

Pharmacokology

citicolin stimulates the biosynthesis of the structural phospholipids of the nerve cell membrane. Therefore, citicolin improves the function of the membrane mechanism such as the function of ion exchange pumps and receptors attached to it, the modulation of this function is essential in neurotransmitter.

Cellin cell membrane stability effects to improve the reabsorption through the nerve cell membrane when brain edema.

Experimental studies for replacing citicolin inhibit the activity of some phospholipase (A1, A2, C and D), reducing the formation of free radicals, avoiding destroying membrane systems and protecting antioxidant defense systems such as glutathion.

citicolin protects the energy reserve of nerve cells, inhibits cell death according to the program and stimulates acetylcholin synthesis.

On experiments shows that citicolin also works to report prophetic neuropathy in ischemia.

Clinical trials of neurological images show that citicolin significantly improves function in patients with acute aemia stroke due to acute ischemia, while slowing down the progression of ischemic damage. In patients with traumatic brain injury, citicolin promotes recovery and reduces the time and severity of brain disease after damage.

citicolin improves concentration, awareness, memory loss and perceptions and nerves due to ischemia.

pharmacokinetic pharmacokinetics

citicolin is well absorbed after drinking, intramuscularly or intravenously. The concentration of cholin in plasma increases significantly after taking the drug in the above -mentioned lines. The oral absorption is almost completely and bioavailable as approximately as intravenous. The drug is metabolized in the intestine and liver into cholin and cytidin.

Citicolin after use is widely distributed in, brain structure, cholin quickly connected with structural phospholipids and cytidin associated with nucleotid cytidinic and nucleic acid. Citicolin enters the brain and connects to cell membranes, cells and mitochondria, participating in structural phospholipid elements.

Only a small amount of doses appear in urine and feces (less than 3%). About 12% of the dose is excreted by exhaling.

The process of excretion through urine can be distinguished into two stages: the first phase is about 36 hours, the speed of excretion decreases rapidly, and in the second phase of the excretion speed decreases much more slowly. The same process with excretion through CO2 exhaled, the emissions speed decreased rapidly after about 15 hours and then fell much slower.

Before taking Somazina 1000mg injection treatment for cognitive and sensory disorders (5 tubes x 4ml)

How to use

The drug is used by intravenously or intravenous injection. However, intravenous infusion is given priority than intramuscularly.

Dosage

Average dose of 500 - 750mg in 24 hours.

In case of intravenous injection, the speed must be slow (3-5 minutes depending on the dose).

In case of intravenous infusion, the transmission speed must be from 40 - 60 drops/minute.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Somazina often has unwanted effects (ADR) such as:

Very rare (

Mental disorders: The illusion . Gastrointestinal: Nausea, vomiting, sometimes diarrhea.

Instructions on how to handle ADR

When encountering side effects of the drug, it is necessary to notify the doctor for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Somazina medicine contraindicated in the following cases:

Hypersensitivity to citicolin or one of the ingredients of the drug.

Caution when using

When used by intravenous injection, it must be injected slowly (from 3 to 5 minutes depending on the dose).

When used by drip intravenous injection, the drip rate must be from 40 to 60 drops per minute.

In case of prolonged intracranial hemorrhage, no overdose of 1000mg per day and should be injected with intravenous infusion slowly (30 drops per minute).

The ability to drive and operate machinery

drivers and operating machinery should pay attention because the risk of side effects on mental and nerves such as hallucinations, dizziness, blurring look.

Pregnancy

Somazina does not have enough data for pregnant women. Somazina should not be used during pregnancy unless it is really necessary, only when the treatment benefits are expected to be higher than any possible risk.

Breastfeeding period

Somazina does not have enough data for nursing women.

Drug interaction

citicolin enhances the impact of L - DOPA.

Do not use Somazina simultaneously with drugs containing meclofenoxat.

Storage

In a dry place, avoid light, temperatures below 30⁰C.

Other drugs

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