Somazina 500mg Ferrer solution treatment for acute stroke, neurological sequelae (5 tubes x 4ml)

Dosage form Box of 5 tubes x 4ml
Specifications Citicoline

Ingredient

Composition information	Content
Citicoline	500mg

Uses

indications

Somazina 500mg pills are indicated in the following cases:

Acute treatment and neurological sequelae.

citicolin stimulates the biosynthesis of the structural phospholipids of the nerve cell membrane. Therefore, citicolin improves the function of the membrane mechanism such as the function of ion exchange pumps and receptors attached to it, the modulation of this function is essential in neurotransmitter.

Cellin cell membrane stability effects to improve the reabsorption through the nerve cell membrane when brain edema.

Experimental studies show that citicolin inhibits the activity of some phospholipase (A1, A2, C and D), reducing the formation of free radicals, avoiding destroying membrane systems and protecting antioxidant defense systems such as glutathion.

citicolin protects the energy reserve of nerve cells, inhibits cell death according to the program and stimulates acetylcholin synthesis.

Experimental shows that citicolin also has a preventive neurological effect in ischemia.

Clinical trials on neurological imaging shows that citicolin significantly improves function in patients with acute stroke due to acute ischemia, while slowing down the progression of chemical anemia damage.

In patients with traumatic brain injury, citicolin promotes recovery and reduces the time and severity of brain disease after damage.

citicolin improves the level of concentration, awareness, dementia and cognitive and nervous disorders related to ischemia.

Dynamic pharmacology

citicolin is well absorbed after oral, intramuscularly or intravenously. The concentration of cholin in plasma increases significantly after taking the drug in the above -mentioned lines. The drug is metabolized in the intestine and liver into cholin and cytidin. Citicolin, after use, is widely distributed in the brain structure, the cholin quickly connects to the structural phospholipid and cytidine associated with nucleotid cytidinic and nucleic acid. Citicolin enters the brain and connects to cell membranes, cells and mitochondria, participating in structural phospholipid elements.

Only a small amount of dosage appears in urine and feces (below 3/9). About 12% of the dose is excreted through CO2 exhaled. The process of excretion through urine can be distinguished into two stages: the first phase is about 36 hours, the speed of excretion decreases rapidly and in the second phase of the excretion speed decreases much more slowly. The same process with excretion through CO2 exhaled, the emissions speed decreased rapidly after about 15 hours and then fell much slower.

Before taking Somazina 500mg Ferrer solution treatment for acute stroke, neurological sequelae (5 tubes x 4ml)

How to use

Treatment time in the exacerbation is 6 weeks and in the chronic period that can last 12 months, depending on the severity of the symptoms to be treated, specifically:

stroke due to ischemia or cerebral hemorrhage and traumatic brain injury: Somazina is appointed immediately or many days/week after symptoms onset with a normal dose of 1 g/12 hours ie 2 g/day. Treatment time is usually 6 weeks.

Neurological sequelae of mutation or due to traumatic brain injury: The common dose is from 500 - 1 g/day. Treatment time can last 12 months.

Dosage

Adults

Dosage recommended from 500 to 2,000 mg/day, depending on the condition and response of the patient.

Somazina can be used for intramuscular injection, slow intravenous injection (from 3 to 5 minutes depending on the dose) or drip intravenous infusion (drip speed: 40 - 60 minutes).

Elderly

No need to adjust the separate Somazina dose for this age group.

Children

Experience in using drugs in children is limited. Therefore, only medication only when the treatment benefits are expected to be higher than any risk that may occur.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget 1 dose? If it is nearly time to take the next dose, skip the forgotten dose and take medicine at the next recommended dose. Do not take double dose to compensate for the forgotten dose.

Side Effects

When using Somazina 500 mg , you may experience unwanted effects (ADR).

Very rare (

Mental disorders: illusion.

Nervous system disorders: headache, dizziness, insomnia. vascular disorders: arterial hypertension, arterial hypotension.

Respiratory disorders, chest and mediastinum: Difficulty breathing.

visual disorders : blurred vision.

Gastrointestinal disorders: Nausea, vomiting, sometimes diarrhea.

Skin and subcutaneous tissue disorders: flushing, urticaria, rash, hemorrhage.

Total and injectable disorders: Run fever, edema.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Somazina 500 mg contraindicated in the following cases:

sensitive to citicolin or any ingredients of the drug.

Patient increases the vice -sympathetic system.

Caution when used

When used by intravenously, it must be injected slowly (from 3 to 5 minutes depending on the dose).

When used by drip intravenous injection, the drip rate must be from 40 - 60 drops per minute.

In case of prolonged intracranial hemorrhage, no overdose of 1000 mg per day and should be injected with intravenous infusion slowly (30 drops per minute).

The ability to drive and operate machinery

drivers and machinery operators should pay attention because the risk of side effects on mental and nerves such as hallucinations, dizziness, blurring look.

Pregnancy

There is no enough data on the use of citicolin in pregnant women.

Do not use somazina during pregnancy unless really necessary. Only used when the treatment benefits are expected to be higher than any possible risk.

Breastfeeding period

There is no enough data on the use of citicolin in nursing women.

Drug interaction

citicolin enhances the impact of L-DOPA.

Do not use Somazina simultaneously with drugs containing meclofenoxat.

Storage

Store in a dry place, temperature below 30 ° C.

Other drugs

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