Southeast Domela medicine treats stomach and duodenal ulcer (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Bismuth tripotassium dicitrat
Ingredient Gastroesophageal reflux

Ingredient

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Composition information	Content
Bismuth tripotassium dicitrat	300mg

Uses

Indications

The drug prescribed to treat stomach and duodenum ulcers.

Pharmacokology

ATC code: A02BX05

Domela contains Bismuth Tripotassium dicitrate is a stable Bismuth salt complex in the form of glue that supports the treatment of peptic ulcer. Bismuth Tripotassium dicitrate is made up of acid pH with amino acids caused by necrotic ulcer to form protective membrane in the site of ulcer, and thus protects ulcers from gastric acid. It strengthens the protective mucus by stimulating the creation of endogenous Prostaglandin.

bismuth tripotassium dicitrate pushes H. pylori out of the stomach mucous membrane, so after treating the recurrence is lower than the H2 resistance treatment.

pharmacokinetic

absorption

bismuth tripotassium dicitrate is mainly acting on the spot. However, there is a very small amount of bismuth absorbed through the gastrointestinal tract. This amount of absorption depends on the initial dose and reaches a peak after 4 weeks of use. With a dose of 480 mg/day, bismuth concentration in the blood averages about 7 ng/ml (alarm concentration is 50 - 100 ng/ml).

Distribution

On testing animals, most bismuth absorbs to the kidneys, in other organs are just traces. On the unknown person.

transformation

No information.

Excretion

Most bismuth in the bismuth tripotassium dicitrate is excreted in feces as bismuth sulfit. Small amount of absorption bismuth is eliminated through the kidney at a speed of about 2.6%/day and takes about 2 months to completely discharge.

Before taking Southeast Domela medicine treats stomach and duodenal ulcer (10 blisters x 10 tablets)

How to use

oral drugs. Drink 30 minutes before eating. Swallowing the whole tablet with half a glass of water. The maximum time for a period of treatment is two months; Domela should not be used for maintenance treatment.

Dosage

Dosage: Take 2 capsules/time, 2 times a day, use 4 to 8 weeks.

Children: Do not recommend use.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In case of overdose, stop taking drugs, symptomatic treatment and supportive measures.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Domela often has unwanted effects (ADR) such as:

Common, ADR> 1/100

Digestive: Black feces due to Bismuth Sulfit formation but can be easily distinguished from black feces due to gastrointestinal bleeding.

Uncommon, 1/1000

Digestive: Nausea, vomiting, constipation, diarrhea.

skin and subcutaneous tissue disorders: rash, itching.

Rare, ADR

The immune system: Anaphylactic reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below

Contraindicated

contraindicated domela in the following cases:

Too hypersensitivity to bismuth tripotassium dicitrate or any ingredient of the drug.

Not used in case of low diet potassium.

Severe kidney failure.

Be cautious when using

should not be used simultaneously with drugs containing bismuth.

black fertilizer due to excretion through feces in the form of bismuth sulfit.

Overdose and prolonged use should be avoided.

This drug contains about 50 mg of potassium in each tablet. Need to be considered in patients with impaired renal function or patients with untrusted potassium diet.

In drugs containing excipients:

Lactose Monohydrate: Patients with rare genetic disorders in galactose tolerance, Lactose Lapp or Glucose - Galactose absorption disorders should not be used.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Use drugs for pregnant or nursing women

domela contraindicated use during pregnancy. There is no information about the excretion of breast milk.

Drug interaction

domela reduces the absorption of iron and calcium when used simultaneously.

Used with antacids, carbonate drinks such as beer, milk or protein foods, which can reduce the effectiveness of Domela. In this case, it is advisable to take the medicine 30 minutes before eating or after eating.

Pre -treatment with omeprazol increases the absorption of bismuth salt 3 times, suggesting an increase in the risk of toxicity if using these 2 drugs.

Simultaneously used with H2 antagonists, or acid resistance reduces the effectiveness of bismuth salts compared to when used alone in ulcerative disease.

The effect of oral tetracyclin can be inhibited when used simultaneously with bismuth.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

Other drugs

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