Sovalimus ointment 0.03% Hadiphar treatment of dermatitis (10g)

Dosage form Tube
Specifications Tacrolimus

Ingredient

Composition information	Content
Tacrolimus	0.03%

Uses

indications

Sovalimus drugs are indicated for short -term and long -term cases of non -continuous treatment for patients with medium and severe dermatitis, but common replacement treatments are not indicated and risks or treatments for non -response patients who do not respond or intolerance to conventional treatment drugs.

Pharmacokic

tacrolimus is a macrolid immunosuppressant, caused by the streptomyces strain Tsukubaensis. The drug is only used in dermatitis.

The mechanism of action of Tacrolimus in dermatitis is not known. It has been proven that Tacrolimus inhibits the activity of T lymphocytes due to combined with cell protein (FKBP-12).

Tacrolimus-FKBP-12 complex, calcium, calcorulin and calcineurin are formed and phosphatase activity of Calcineurin is inhibited.

This effect has prevented the Dephosphorylation and the permutation of the nuclear factor of T cells, a component in the nucleus, starting the genetic copy to form lympholine lymphocytes (such as Interleukin-2, Gamma Interferon).

Dynamic pharmacokinetics

The absorption of drugs into the body of Tacrolimus is very small. After a single dose or multiple dose with Tacrolimus ointment 0.03%, the maximum concentration in the blood achieved from 5 - 20 ng/ml.

The absolute use of Tacrolimus is unknown.

There is no evidence of the accumulation of Tacrolimus in the body when applying non -continuous drugs for 1 year.

Before taking Sovalimus ointment 0.03% Hadiphar treatment of dermatitis (10g)

How to use

Sovalimus drugs are used by applying skin.

Do not cover the wound when using Sovalimus 0.03%.

Dosage

Adults and children over 2 years:

Apply a thin layer of Sovalimus drug 0.03% to the infected skin 2 times/day and gently rub for the drug evenly. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Used oral with Sovalimus ointment can lead to unwanted effects that have been determined with Tacrolimus using inner sugar.

If you accidentally use oral, you must immediately consult your doctor.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Sovalimus, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Nervous system: depression, dizziness, dizziness, migraine, neck pain, neuritis, anxiety.

liver: increase Alt or AST. Blood: Hemolytic reduction, increased leukopenia, increased creatinine, increased blood glucose, hypoglycemia. Cardiovascular: vasodilation, hypertension, tachycardia, peripheral vascular disorders, arrhythmia, angina.

Digestive system: Gastritis, anorexia, constipation.

allergies: anaphylactic reaction, angioedema.

Genital system: Vaginal monilia.

Other: joint pain, chest pain, cell inflammation, lipitis, chills, dehydration, shortness of breath, pain in the skin, edema, nosebleeds, visual disorders, sensitive to light, skin discoloration, sweat, taste loss, tooth disease.

Uncommon, 1/1000

Body: burns skin, itching, allergic reactions, skin rash, skin infections, fever, herpes simplex, eczema, contact dermatitis, skin peeling.

Heart: Bronchial asthma, sore throat.

Digestive system: Nausea.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Sovalimus drugs contraindicated in the following cases:

Patients with a history of sensitivity to Tacrolimus or any ingredients of the preparation.

Children under 2 years old.

Patients with Netherton syndrome can increase the absorption of Tacrolimus into the body.

Be cautious when used

Before starting treatment with Tacrolimus ointment, clinical infection areas must be cleaned at treatment sites. When patients with Eczema Herpeticum dermatitis, treated with Tacrolimus ointment may increase the risk of Varicella Zoster virus infection (chickenpox or shingles), herpes simplex virus, or Eczema herpeticum. In this case, it is necessary to consider the benefits and harms of the treatment with Tacrolimus ointment.

Organs patients are taking immunosuppressive drugs (for example, Tacrolimus used in the high risk of lymphoma development, so patients who use Tacrolimus ointment and people with lymph nodes must clearly identify the cause of lymph nodes. If there is no clear cause of lymph nodes or mononucleic hyperpens caused by acute bacterial infections, tacrolimus ointments must be stopped.

Patients with lymph nodes, monitoring to make sure the lymph nodes have been resolved. Patients must be cautious to minimize or avoid exposure to natural or artificial light.

Tacrolimus ointment can cause local symptoms such as burning skin (burning, irritation, pain) or itching. These symptoms most occur in a few days of treatment and significantly improved after treatment of dermatitis.

Safety of Tacrolimus ointment for patients with unpretermined skin erythematosus.

The ability to drive and operate machinery

No information.

Pregnancy

No information.

Breastfeeding period

There is no information.

Interactive drug

has not conducted studies on drug interaction between usual drugs with sovalimus ointment.

Due to the very small amount of drugs absorbed, the interaction between Sovalimus and clear drugs may not occur, but it is not out of the rule, so it must be cautious when combining treatment with CYP3A3 inhibitors (such as with erythromycin, Itraconazole, Ketoconazole, Fluconazole, Calcium and Cimetidine channels) Skin on a large scale and/or red skin.

Storage

In a cool dry place, temperatures below 30 ° C, avoid light.

Other drugs

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