Sovepred Mekophar effervescent pellets treat rheumatoid arthritis, lupus erythema (30 tablets)

Dosage form Box of 30 tablets
Specifications Prednisolone

Ingredient

Composition information	Content
Prednisolone	5mg

Uses

Indications

Sovepred drugs are indicated in cases where anti -inflammatory and immunosuppressive effects are required:

rheumatoid arthritis, body lupus, some vascular inflammation: temporal arteritis and inflammation around the artery, sarcoid disease, bronchial asthma, ulcerative colitis, hemolytic anemia, granulocytopenia and severe allergens including anaphylaxis.

Pharmacokological

Pharmacological group: anti -inflammatory drugs corticosteroid, glucocorticoid.

Prednisolone is a glucocorticoid that has anti -inflammatory, anti -allergic and immunosuppressive effects.

Prednisolone only has weak mineralcorticoid effects, so if you take the drug in a short time, there is very little risk of sodium and edema. The anti -inflammatory effect of prednisolone compared to other glucocorticoids: 5mg Prednisolone is valid equal to 4 mg methylprednisolone and equal to 20 mg of hydrocortisone.

Prednisolone inhibits leukocytes and infection into inflamed tissue.

Prednisolone uses systemic sugar to reduce the number of lymphocytes, eosin blood cells, mononuclear leukocytes in peripheral blood and reduce their movement into inflamed areas. The drug also inhibits the function of lymphocytes and macrophages at tissue.

Prednisolone also reduces prostaglandin synthesis due to phospholipase inhibition A2.

corticosteroids also increase lipocortin levels, inhibit phospholipase A2. Finally, the drug reduces cyclooxygenase in inflammatory pangolin, thus reducing the amount of enzyme to produce prostaglandin.

Prednisolone reduces capillary permeability due to the inhibition of the activity of kinine and bacterial internal toxins and reduces the amount of hydrophilia by base leukocytes.

The immunosuppressive effect of glucocorticoid is largely due to the above effects. With low doses, glucocorticoids have anti -inflammatory effects, with high doses of glucocorticoids have immunosuppressive effects.

Prednisolone is also valid in heavy bronchial asthma.

pharmacokinetic pharmacokinetics

bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -biochemicals of prednisolone approximately 82%. Plasma peak concentration reaches 4 hours after taking the drug.

Prednisolone is linked to protein about 90 - 95%. The clearance of Prednisolone is 8.7 ± 1.6ml/min/kg. The distribution of the drug is 1.5 ± 0.2 liters/kg.

Prednisolone is metabolized in the liver and metabolites are the form of sulfate and glucuronide esters, excreted into urine and bile. Half lifetime elimination of Prednisolone is approximately 2.5 - 3.5 hours.

Before taking Sovepred Mekophar effervescent pellets treat rheumatoid arthritis, lupus erythema (30 tablets)

How to use

Sovepred drugs are dissolved in a glass of water, drink at breakfast.

Dosage

Dosage depending on the type of disease and severity/mild severity/mild/response and patient tolerance. Should drink once a day in the morning at a meal. After controlling the disease, reduce the dose slowly to the lowest dose effectively.

When a long -term treatment is required, it is recommended to use a Japanese treatment regimen, taking a single dose in the morning in the morning of natural corticosteroids for 24 hours to reduce side effects.

Reduce the dose slowly from stopping the drug.

Adults

Initial dose: 0.35 - 1.2mg/kg/day.

Children

Dosage is based on the severity/mild disease of the disease, responding as well as the patient's weight.

Initial dose: 0.5 - 2mg/kg/day.

Maintenance dose: 0.25 - 0.5mg/kg/day.

Dosage in some pathologies as follows

Chronic pathologies (endocrine disorders, hematology, skin diseases): Starting dose of 5 - 10mg/day and adjustment to the lowest dose effectively.

Birth The adrenal glands: 2.5 - 10mg/day.

Allergy, rheumatism: 20 - 30mg/day.

Lupus erythematosus, low heart, muscle inflammation: Starting dose 30mg/day.

Note: The dose above is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

If the overdose occurs, it is recommended to go to the nearest medical facility for medical staff to have timely treatment methods.

What to do when you forget 1 dose? If you remember near the next medication, skip the forgotten dose and take the next dose.

Side Effects

When using SovePred, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nervous system: Insomnia, nervousness is easily agitated.

Neurology - muscle and bone: joint pain.

Eye: cataracts, glaucoma.

Central nervous system: dizziness, convulsions, mental disorders, fake brain, headache, mood change, delirium, hallucinations, refreshment.

Cardiovascular: edema, hypertension.

Skin: acne, skin atrophy, bruising, hyperpigmentation.

Endocrine and metabolism: Cushing syndrome, pituitary inhibition, adrenal, slow growth, glucose intolerance, hypokalemia, alkaline infection, amenorrhea, sodium and water, hyperlem of blood glucose.

nervous - muscle and bone: weak muscle, osteoporosis, broken bone.

Other: Hypersensitivity reaction.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Sovepred drugs contraindicated in the following cases:

hypersensitively to one of the ingredients of the drug.

Severe infections, except for bacterial shock and meningitis.

Virus, fungal or tuberculosis skin infections.

is using live virus vaccine.

Precautions when using

Use cautiously in people with osteoporosis, newly connected people (intestines, blood vessels), mental disorders, stomach ulcers, diabetes, hypertension, heart failure, heart failure and growing children.

Due to the risk of unwanted effects, caution must be used with all body corticosteroids for the elderly, with the lowest doses and in the shortest possible time.

Acute adrenal insufficiency may occur when the drug is stopped suddenly after a long time of treatment or when there is stress.

When using high doses, it can affect the effects of vaccination.

The ability to drive and operate machinery

has not recorded a adverse reaction report or no research on the effects of the drug on the ability to operate machinery, train drivers, higher people working and other cases.

Pregnancy

only use the drug when really necessary.

Breastfeeding period

Drug interaction

Prednisolone impacts the metabolism of cyclosporine, erythromycin, phenobarbital, phenytoin, carbamazepine, ketoconazole, rifampicin.

Phenytoin, Phenobarbital, Rifampicin and diuretics decreased blood potassium can reduce Prednisolone effect.

Prednisolone can cause hyperlemor of blood glucose, so higher insulin dose is needed.

Avoid simultaneous use of prednisolone with nonsteroidal anti -inflammatory drugs as it can cause stomach ulcers.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.