Spamerin 135mg Abbott treatment of irritable bowel syndrome, abdominal pain and abdominal cramps, diarrhea (30 tablets)

Dosage form Film bag tablets
Specifications Box of 3 blisters x 10 tablets
Ingredient Mebeverine Hydrochloride

Ingredient

Composition information	Content
Mebeverine Hydrochloride	135mg

Uses

indications

spamerin pills are indicated in the following cases:

Mebeverin is used in the treatment of symptoms of irritable bowel syndrome (colon irritation, spasmic colon disorders, muscles, constipation caused by spasms, neurological -related diarrhea), such as abdominal pain and abdominal pain, non -specific diarrhea (with or without alternating constipation) and bloating. physical pathology.

ATC code: A03AA04.

Mebeverin is an anti -spasm that works directly on the digestive tract smooth muscles without affecting normal intestinal peristalsis. The drug is also used in cases such as irritable bowel syndrome.

The exact mechanism of effect of the drug is not well known, but there are many different mechanisms such as reducing ion absorption through cell absorbent membrane, blockade of noradrenalin reabsorption, local anesthesia, changing water absorption as well as Muscarinic resistance and inhibiting weak phosphodiesterase effects that can contribute to the effect in the local effect of Mebeverin on the gastrointestinal tract.

pharmacokinetics

absorption: Mebeverin is absorbed quickly and completely after drinking.

Distribution: There is no significant sign of drug accumulation after dosage.

Metabolic: Mebeverin hydrochloride is converted mainly by the esteraza enzyme dividing the ester bond into veratric acid and Alcohol Mebeverin first.

Main metabolites in plasma are DMAC (Demethylated carboxylic acid).

The disposal time in the stable state of DMAC is 2.45 hours. When taking multiple doses of 135 mg cmax film tablets is 1670 ng/ml and tmax is 1 hour.

Elimination: Mebeverin is not eliminated in the form of ungusted, the drug is completely metabolized, the metabolic is almost completely excreted. Veratric Acid and Mebeverin Alcohol are excreted into urine, partly in the form of carboxylic acid (Mac) and partly in the form of methyl carboxylic acid (DMAC).

Pediatric patients: Safety and effectiveness of drugs are only set in adults.

Before taking Spamerin 135mg Abbott treatment of irritable bowel syndrome, abdominal pain and abdominal cramps, diarrhea (30 tablets)

How to use

oral tablets. Take the tablet with a glass of water.

Dosage

Adults and children over 18 years old: 1 tablet x 3 times/day.

Should take medicine 20 minutes before meals. The dose can be reduced after the desired response.

Children's patients: Mebeverin 135 mg film tablets are not recommended for children and minors under 18 years old, because there is no enough data on the safety and effectiveness of the drug when used for these objects.

Special patient group: Dosage research data for older patients, liver failure, renal failure has not been established.

In after -sales reports, there are no specific risks when taking drugs for older diseases, liver failure, renal failure. No need to adjust the dose is considered necessary for these objects.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? There is no specific antidote. Treatment by gastrointestinal and symptomatic treatment.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using spamerin may experience unwanted effects (ADR) such as:

Very rare: digestive disorders, dizziness, headache, insomnia, anorexia, heart rate.

Allergies, including rash, urticaria, and angiography have been reported.

Stop using and consulting your doctor if: abnormal new symptoms or unwanted effects appear or become worse.

Instructions on how to handle ADR:

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Spamerin drugs contraindicated in the following cases:

Hypersensitivity to the Mebeverin Hydrochorid or any ingredient of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Avoid using drugs in patients with porphyrin metabolic disorders.

The effect of the drug on driving and operating machinery

Mebeverin can cause dizziness and headache.

Be careful when taking drugs in people who are operating trains and operating machinery.

Use drugs for women during pregnancy and nursing mothers

Using drugs for pregnant women: The safety and effectiveness of drugs in pregnant women have not been established. Do not record teratogenic drugs in animal research. However, be careful when taking drugs on pregnant women.

Use medication for breastfeeding women: Small amount of mebeverin is excreted in breast milk. So avoid using this medication for breastfeeding women.

Drug interaction

No report.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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