Spiramycin medicine 3,000,000 I.U Vidipha Treatment of respiratory infections (10 tablets)

Dosage form Box of 2 blisters x 5 tablets
Specifications Spiramycin

Ingredient

Composition information	Content
Spiramycin	3,000,000iu

Uses

Indications

Spiramycin medicine 3,000,000 I.U is indicated in the following cases:

Infections in the respiratory, skin and genitals caused by sensitive bacteria. penicillin. The drug has the effect of pliers in bacteria that are dividing cells. In serum concentrations, the drug has a bactericidal effect, but when the concentration of the drug can kill bacteria. The mechanism of action of the drug is an effect on the subunit of 50S units of bacterial ribosome and preventing protein synthetic bacteria.

In places where the drug level is very low, Spiramycin has a resistance to Gram -positive strains, coccus strains such as Staphylococcus, Pneumococcus, Meningoccus, most Gonococcus strains, 75% Streptococcus and Enteroccus. The strains of Bordetella Perussis, Corynebacteria, Chlamydia, Actinomyces, some Mycoplasma and Toxoplasma strains are also sensitive to Spiramycin.

Spiramycin does not work with Gram -negative intestinal bacteria. There has also been a notice of bacterial resistance for spiramycin, including cross -resistance between Spiramycin, erythromycin and oleandomycin. However, erythromycin strains are sometimes still sensitive to spiramycin.

pharmacokinetic

absorption

Spiramycin is not completely absorbed in the digestive tract. Oral drugs are absorbed about 20-50% of the dose of use. The peak concentration of plasma is achieved within 2-4 hours after drinking.

Peak concentration in plasma after taking 1 g dose is 1 microgram/ml. The peak concentration after the single dose can be maintained for 4-6 hours. Drinking Spiramycin when there is food in the stomach greatly reduces the bioavailability of the drug. Food reduces about 70% of the maximum concentration of the drug in the serum and makes the peak time from 2 hours.

Distribution

Spiramycin is widely distributed throughout the body. The drug reaches high concentrations in the lungs, tonsils, bronchial and sinuses. Spiramycin is less penetrated into the cerebrospinal fluid.

Elimination

The average selling time is 5 - 8 hours. The drug is excreted mainly in bile. The concentration of drugs in bile is 15 - 40 times larger than the serum concentration. After 36 hours, only about 2% of the total dose is found in the urine.

Before taking Spiramycin medicine 3,000,000 I.U Vidipha Treatment of respiratory infections (10 tablets)

How to use

Spiramycin 3,000,000 I.U is used orally.

Dosage

Adults

1,500,000–3,000,000 Lu/day x 3 times/day.

Children

150,000 lu/kg body weight/24 hours, divided into 3 times.

Preventive treatment for meningitis caused by meningococcus strains

Adults

3,000,000 IU every 12 hours

Children

75,000 lu/kg body weight every 12 hours, for 5 days.

Preventive prophylaxis of congenital toxoplasma during pregnancy

9,000,000 lu/day, divided into several times for 3 weeks, 2 weeks away for the reminders.

Use in combination or alternating with Pyrimethamine/Sulfonamide treatment regimen that can achieve better results.

Food in the stomach reduces the bioavailability of Spiramycin, so it is necessary to give the medication before meals for at least 2 hours or after a 3 -hour meal.

Patients using Spiramycin must adhere to the full treatment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Support treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Spiramycin 3,000,000 I.U , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea , indigestion (when used orally).

Uncommon, 1/1000

Body: fatigue, nosebleeds , sweating, chest pressing.

digestive: acute colitis. DA: BAN DA, NOM, urticaria .

Rare, 1/10000

Systemic: Anaphylactic reaction, superinfection due to long -term use of spiramycin oral medicine.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Spiramycin 3,000,000 I.U Contraindications in the following cases:

People with a history of hypersensitivity to Spiramycin, erythromycin or any ingredients of the drug.

Caution when using

Use cautiously when using Spiramycin for people with liver dysfunction, because the drug can be toxic to the liver.

The ability to drive and operate machinery

The drug does not affect the driver and operating machinery.

Pregnancy

Spiramycin passes through the placenta, but the concentration of drugs in the fetal blood is lower than in the mother's blood. Spiramycin does not cause complications when used for pregnant people.

Breastfeeding period

Spiramycin excreted breast milk with high concentrations. Should stop breastfeeding while taking the drug.

Medicinal interaction

using spiramycin simultaneously with birth control pills will lose the effect of contraception.

Storage

In a dry place, avoid light, temperature below 30 ° C.

Other drugs

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