Spirastad 1.5 M.I.U Stella medicine for preventive meningitis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Spiramycin

Ingredient

Composition information	Content
Spiramycin	1500000iu

Uses

indications

Spirastad drugs are indicated in the following cases:

is the second choice to treat cases of infections in the respiratory, skin and genitals caused by sensitive bacteria. penicillin. The drug has the effect of pliers in bacteria that are dividing cells. In serum concentrations, the drug has a bactericidal effect, but when the concentration of the drug can kill bacteria. The mechanism of action of the drug is the effect on the subuniters of 50S of bacterial ribosome and prevent protein synthesis bacteria. In places with very low resistance levels, Spiramycin has a resistance to Gram -positive strains, coccus strains such as Staphylococcus, Pneumococcus, Meningoccus, most Gonococcus strains, 75% of Streptoccus strains, and Enterococcus. The strains of Bordetella Perussis, Corynebacteria, Chlamydia, Actinomyces, some Mycoplasma and Toxoplasma strains are also sensitive to Spiramycin.

Spiramycin does not work with Gram -negative intestinal bacteria. There has also been a notice of bacterial resistance for spiramycin, including cross -resistance between Spiramycin, erythromycin and oleandomycin. However, erythromycin strains are sometimes still sensitive to spiramycin.

Pharmacokinetics

absorption

Spiramycin is not completely absorbed in the digestive tract. Oral drugs are absorbed about 20-50% of the dose of use. The peak concentration of plasma is achieved within 2-4 hours after drinking. The peak concentration in plasma after the 1 g dose is 1 m microgam/ml. The concentration of peaks in the blood after the single dose can be maintained for 4 to 6 hours. Drinking Spiramycin when there is food in the stomach greatly reduces the bioavailability of the drug. Food reduces about 70% of the maximum concentration of the drug in the serum and makes the peak time from 2 hours.

Distribution

Spiramycin is widely distributed throughout the body. The drug reaches high concentrations in the lungs, tonsils, bronchial and sinuses. Spiramycin is less penetrated into the cerebrospinal fluid. Serum concentration has a bactericidal effect in the range of 0.1 - 3.0 micrograms/ml and the concentration of the drug in tissue has a bactericidal effect in the range of 8 - 64 micrograms/ml. Oral Spiramycin has half a short distribution (10.2 + 3.72 minutes).

Elimination

The average selling time is 5 - 8 hours. The drug is excreted mainly in bile. The concentration of drugs in bile is 15 - 40 times larger than the serum concentration. After 36 hours, only about 2% of the total dose is found in the urine.

Before taking Spirastad 1.5 M.I.U Stella medicine for preventive meningitis (3 blisters x 10 tablets)

How to use

oral medication. Food in the stomach reduces the bioavailability of Spiramycin, so it is necessary to take medicine before meals for at least 2 hours or 3 hours after meals.

Patients using Spiramycin must follow the end of the treatment.

Dosage

Adults: 1500000–30000 IU, 3 times in 24 hours.

Children and children: 150000 IU/kg/24 hours, divided into 3 times.

Preventive treatment for meningitis caused by meningococcus strains

Adults: 3000000 IU, every 12 hours.

Children: 75000 IU/kg, every 12 hours, in 5 days.

Preventive prophylaxis of congenital toxoplasma during pregnancy

9000000 IU/day, divided into several times for 3 weeks, 2 weeks away for the reminders.

Use in combination or alternating with Pyrimethamine/Sulfonamide treatment regimen that can achieve better results.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Spirastad, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea, indigestion.

Uncommon, 1/1000

Body: fatigue, nosebleeds, sweating, chest pressing.

temporary, staggering, staggering, staggering, muscle and joints. digestive: acute colitis.

Skin: Ban Da, Ban Ban, Rural.

Rare, 1/10000

Systemic body: Anaphylaxis, superinfection due to long -term use of spiramycin oral medicine.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

SPIRASTAD medicine is contraindicated in the following cases:

People with a history of hypersensitivity to Spiramycin, erythromycin or any ingredient of the drug.

Be cautious when using

should be cautious when using spiramycin for people with liver dysfunction, because the drug can be toxic to the liver.

The ability to drive and operate machinery

No report.

pregnancy

spiramycin passes through the placenta, but the concentration of drugs in the fetal blood is lower than the mother's blood. Spiramycin does not cause complications when used for pregnant people.

The period of breastfeeding

Spiramycin is excreted through breast milk with high concentrations. Should stop breastfeeding while taking the drug.

Interactive drug

using Spiramycin simultaneously with oral contraceptive medicine will lose the effect of conception prevention.

Storage

In closed packaging, dry place. The temperature does not exceed 30 ° C.

Other drugs

Disclaimer

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