Spirastad 3 M.I.U Stella Treatment of respiratory infections (2 blisters x 5 tablets)

Dosage form Box of 2 blisters x 5 tablets
Specifications Spiramycin

Ingredient

Composition information	Content
Spiramycin	3000000iu

Uses

Indications

Spirastad 3 M.I.U is indicated in the following cases:

Spiramycin is considered to be the second choice to treat the cases of respiratory, skin, and genital infections caused by sensitive bacteria mentioned above. Acute rheumatoid arthritis in patients with allergies to penicillin. The drug has the effect of pliers in bacteria that are dividing cells. In serum concentrations, the drug has a bactericidal effect, but when the concentration of the drug can kill bacteria. The mechanism of action of the drug is the effect on the subuniters of 50s of the ribosom bacteria and preventing protein synthetic bacteria, in places with very low drug resistance, Spiramycin has an resistance to Gram -positive strains, Coccus strains such as Staphylococcus, Pneumococcus, Meningoccus, most Gonococcus strains, 75% Streptoccus, and EidocCCCS. The strains of Bordetella Perussis, Corynebacteria, Chlamydia, Actinomyces, some Mycoplasma and Toxoplasma strains are also sensitive to Spiramycin.

Spiramycin does not work with Gram -negative intestinal bacteria. There has also been a notice of bacterial resistance for spiramycin, including cross -resistance between Spiramycin, erythromycin and oleandomycin. However, erythromycin strains are sometimes still sensitive to spiramycin.

pharmacokinetic

Spiramycin is not completely absorbed in the digestive tract. Oral drugs are absorbed about 20-50% of the dose of use. The peak concentration of plasma is achieved within 2-4 hours after drinking. The peak concentration in plasma after oral 1g dose is 1 microgram/ml. The concentration of peaks in the blood after the single dose can be maintained for 4 to 6 hours. Drinking Spiramycin when there is food in the stomach greatly reduces the bioavailability of the obstruction. Food reduces about 70% of the maximum concentration of the drug in the serum and makes the peak time from 2 hours.

Spiramycin is widely distributed throughout the body. The drug reaches high concentrations in the lungs, tonsils, bronchial and sinuses. Spiramycin is less penetrated into the cerebrospinal fluid. Serum concentration has a bactericidal effect in the range of 0.1 - 3.0 micrograms/ml and the concentration of drugs in tissue has bactericidal effect in the range of 8 - 64 micrograms/ml.

Spiramycin oral drugs have half a short distribution (10.2 ± 3.72 minutes). The average selling time is 5 - 8 hours. The drug excreted in the bile. The concentration of drugs in bile is 15-40 times larger than serum concentration. After 36 hours, only about 2% of the total dose is found in the urine.

Before taking Spirastad 3 M.I.U Stella Treatment of respiratory infections (2 blisters x 5 tablets)

How to use

Spirastad 3 M.L.U is used by oral. Food in the stomach reduces the bioavailability of Spiramycin, so it is necessary to take medicine before meals for at least 2 hours or 3 hours after meals.

Patients using Spiramycin must follow the end of the treatment.

Dosage

Treatment of cases of infections in the respiratory, skin, and genital infections; Preventive prophylaxis of acute rheumatoid arthritis in patients with allergies to penicillin:

Adults: 6,000,000 - 9,000,000 lu/day, divided 2-3 times. The dose can be up to 15,000,000 lu/day, divided into several times, for severe infections.

Children ≥ 30 kg: 150,000 lu/kg body weight/24 hours, divided into 3 times. Use other preparations for children

Preventive treatment for meningitis caused by meningoccus strains:

Adults: 3,000,000 IU/12 hours, for 5 days.

Children ≥ 20 kg: 75,000 lu/kg body weight/12 hours, for 5 days. Use other preparations suitable for children

Preventive prophylaxis of congenital toxoplasma during pregnancy:

9,000,000 lu/day, divided into several times for 3 weeks, 2 weeks away for the reminders.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? When using high doses, it may cause digestive disorders: nausea, vomiting, diarrhea. Prolonged QT can be encountered, gradually stopping when stopping treatment (encountered in newborns taking high doses or in adults intravenously at risk of extending QT).

In case of an overdose, the electrocardiogram should be used to measure the QT interval, especially when there are other risks (reduced potassium, congenital QT interval, combining the use of drugs that extend the QT and/or causing torsion). There is no antidote. Symptomatic treatment.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Overall, Spirastad 3 M.I.U is well tolerated. Can cause local irritation, especially for patients with sensitive skin.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications

People with a history of hypersensitivity to Spiramycin, erythromycin or any component of the drug.

Precautions when using

Use carefully when using Spiramycin for people with liver dysfunction, because the drug can poison the liver.

Be cautious for people with heart disease, arrhythmia (including people who tend to extend QT).

When starting to treat if you see a whole body with a fever, it is necessary to stop the medicine because it is suspected of having a pustules. This case must be contraindicated for using Spiramycin.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

Spiramycin passes through the placenta, but the concentration of drugs in the fetal blood is lower than in the mother's blood. Spiramycin does not cause complications when used for pregnant people.

Breastfeeding period

Spiramycin excreted breast milk with high concentrations. Should stop breastfeeding while taking the drug.

Medicinal interaction

using spiramycin simultaneously with oral contraceptive medicine will cause loss of conception.

Spiramycin reduces the concentration of levodopa in the blood if used simultaneously.

Spiramycin is small or does not affect the cytochrom P450 enzyme system in the liver; So compared to erythromycin, Spiramycin has less interaction with drugs metabolized by this enzyme.

has been reported on many cases of increased oral anticoagulant activity in patients with antibiotics. Risk factors include the severity of the infection or inflammation, the age of the patient and the general health condition.

Storage

Cool dry storage, avoid light, temperature below 30⁰C.

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