Spiriva Respimat Boehringer

Dosage form Box
Specifications Tiotropium

Ingredient

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Composition information	Content
Tiotropium	0.0025mg

Uses

indications

Spiriva Respimat drugs are indicated in the following cases:

Indications for maintenance treatment for COPD patients (including chronic bronchitis and emphysema). Prolonged, in clinical medicine called cholinergic resistance. The drug has the same affinity as the Muscarinic M1 receptor groups to M5. In the respiratory tract, the inhibition of receptors M3 at plain muscle causes muscle relaxation.

Due to being a 4 -level anti -cholinergic n, Tiotropium selected on the spot (bronchial) when using aerosol sugar, showing the effective treatment before showing the body resistance effect on the body. In studies on in vitro, the dissociation of the drug from receptors m2 is faster than the M3 receptor, deducing the selection on the M3 receptor group more than m2 (dynamic control).

High effectiveness and slow dissociation from receptors shows a clinical association with significant and prolonged bronchodilator effects in COPD patients.

The bronchodilator effect after using Tiotropium is mainly in place (on the respiratory tract) without the whole body effect.

Dynamic pharmacokinetics

Tiotropium bromide is prepared in the form of aerosol solution for use through Respimat gas tools. About 40% of the inhaled dose goes into the target organs is the lungs, the rest goes into the digestive tract.

Tiotropium bromide is a quadratic ammonium compound, less soluble in the hinted gas show that about 33% of the inhaled dose goes into the circulation.

Tiotropium oral solution has absolute 2-3%bioavailability. Food does not affect the absorption of Tiotropium for the above reason. The maximum concentration in the plasma of Tiotropium reaches 5-7 minutes after inhalation.

The drug is connected to 72% plasma proteins and shows that the distribution volume is 32L/kg. It is unclear whether the distribution concentration in the lungs but the use of higher drug suggestions in the lungs.

In patients with COPD after inhaling the gas solution, 18.6% (0.93 mcg) The dose is eliminated through the urine, the rest is mainly eliminated in the fertilizer as an absorbing form in the intestine.

Before taking Spiriva Respimat Boehringer

How to use

drugs for inhalation.

Dosage

The recommended dose of Spiriva Respimat is two sprays from RESPIMAT TEACHERS ALTIMATE A day at the same time.

Do not overdose recommended.

Special patient group:

Elderly patients can use Spiriva Respimat with recommended dose.

Patients with renal failure can use Spiriva Respimat with recommended dose. However, like all the drugs are excreted mainly through the kidneys, should be carefully monitored when using Spiriva Respimat in patients with medium to severe renal impairment.

Patients with liver failure can use Spiriva Respimat with recommended dose.

Children (under 18 years old): COPD is not common in children, so the safety and effectiveness of Spiriva Respimat has not been clearly defined in children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Spiriva Respimat, you may experience unwanted effects (ADR).

Common, ADR> 1/100:

Digestive: dry mouth.

Uncommon, 1/1000

Neurological: headache, dizziness.

Respiratory: cough, sore throat, hoarseness.

digestive: constipation, contamination of pharyngeal candida.

Skin and subcutaneously: itching, rash.

kidney - urinary: urinary retention, difficult urine.

Rare, ADR

Neither: Insomnia.

Eye: Glaucoma, blurred vision, glaucoma.

Cardiovascular: Atrial fibrillation, tachycardia, chest drum. Respiratory: Bronchospasm, laryngitis, nosebleeds.

Digestive: Difficult swallowing, gastroesophageal reflux, tooth decay, stomatitis, tongue inflammation, periodontitis.

Skin and subcutaneous organization: angioedema, urticaria, dry skin, skin infection, skin ulcer. Kidney - Urine: Urinary infection.

Unknown frequency, ADR:

Metabolism: dehydration.

Respiratory: Sinusitis.

digestive: nausea, intestinal obstruction, intestinal paralysis.

Skin and organization subcutaneously: Anaphylaxis.

musculoskeletal joints: swelling.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Spiriva Respimat is contraindicated in the following cases:

Patients who have known hypersensitivity to atropine or its derivatives, such as ipratropium or oxitropium, or any ingredient of the drug.

Be cautious when using

Spiriva Respimat, as a maintenance bronchodilat medicine at a dose once a day, should not be used to start the initial treatment in acute bronchial spasms such as attack therapy.

There may be instant hypersensitivity reactions after using Spiriva Respimat.

As well as other anti -cholinergic drugs, the cautious Spiriva Respimat should be used in patients with narrow -angle glaucoma, prostate hypertrophy or bladder obstruction.

Inhaled drugs can cause bronchospasm due to inhalation.

Should use Spiriva carefully and closely monitor in patients with medium and severe renal impairment (clearing creatinine

Need instructions for patients to use Spiriva Respimat properly. Be careful to avoid the solution or the mist into the eyes. Pain or discomfort in the eyes, blurred vision, glow or images with many colors accompanied by redness due to conjunctival conjunctiva and corneal edema can be a sign of acute narrow -angle glaucoma. Specialized examination should be examined immediately if any combination of the above symptoms appears. Eye drops that cause pupils are not effective treatment.

Observed dry mouth when treating cholinergic antagonists, can be prolonged related to tooth decay.

Do not use Spiriva Respimat more than once a day.

Spiriva tube can only be used with Respimat gas tools.

The ability to drive and operate machinery

There is no research on affecting the ability to drive and use machines. The appearance of dizziness or blurred vision can affect the ability to drive and use machines.

Pregnancy

There is no clinical data on the use of Spiriva for pregnant women.

Therefore, Spiriva Respimat should not be used for pregnant or breast -feeding women unless the expected benefits are out of the risk of fetal and emulsion.

Lactation period

There is no clinical data on the use of tiotropium for nursing women.

Therefore, Spiriva Respimat should not be used for pregnant or breast -feeding women unless the expected benefits are out of the risk of fetal and emulsion.

Drug interaction

Although the official drug interaction has not been conducted, Tiotropium Bromide has been used with other common COPD treatments, including sympathetic bronchodilators, methylxanthine, oral and inhaling steroids, without seeing clinical interactive evidence.

Commonly used drugs (laba, ICS and their combination) are used for COPD patients who have not been detected, causing changes in Tiotropium concentration.

Not researched for long -term combination of tiotropium bromide with anti -cholinergic drugs. Therefore, Spiriva Respimat should not be used in combination with other anti -cholinergic drugs for a long time.

Storage

The temperature does not exceed 30 ° C, not frozen.

Store Spiriva Respimat:

Clean the sucking tube, including the metal inside the pipe with a damp towel or a tissue at least once a week.

The function of Spiriva Respimat gas tool is not affected by any small discoloration on the suck tube.

Can wipe off the surface of the Spiriva Respimat tank with a damp towel if necessary.

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