Spiromide 20/50mg Search decreased edema, diuretic, hypotension (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Spironolactone, Furosemid

Ingredient

Composition information	Content
Spironolactone	50mg
Furosemid	20mg

Uses

Indications

Spiromide is indicated in the following cases:

Special edema when there is secondary Aldosterone. The learning force

spironolactone is an inhibitor of competition for the combination of aldosterone with its receptor. Its important operating position is far away, where it is combined with the soluble aldosterone receptor in the cytoplasm to form an inactive complex.

A series of biochemical reaction chains lead to a combination of proteins with physiological activity, diuretic and low voltage.

Using Spironolactone with electrolyte disorders, contributing to increasing the lenin activity in the serum in the experimental mouse.

Another effect but less important is the direct inhibition of the adrenal aldosterone synthesis. Spironolactone is the most important lactone steroid in clinical applications; The drug acts as a diuretic and antihypertensive drug due to the inhibition of Na+ Na+ inhibitors of aldosterone, and partially inhibits the adrenal cortisol of aldosterone.

Furosemide is the derivative of anthranilic acid, belonging to the strap gender group. Furosemide has a diuretic effect by: blocking the co-transport mechanism in the branch of Henle straps, increasing the excretion of Na+, K+, Cl-, leading to water, so the diuretic benefits; Increasing blood flow through the kidneys, increasing renal fishing, and renal vasodilation, redistributing blood benefits for remote areas in the kidney shells, resistance to ADH in the distance; Varicose veins, reducing blood stasis in the lungs, reducing left ventricular pressure; Increase Ca ++, Mg ++ elimination and reduce Ca ++, Mg ++ blood.

pharmacokinetic

spironolactone

The absorption of spironolactone by oral can change the taste of the drug is less soluble in water. Using medicine after eating will increase absorption, can slow down the process of stomach, food promotes the decomposition of drugs and improves the dissolution of the drug.

Moreover, bile acid secreted during meals can dissolve spironolactone, which is a lipid -loving substance. Peak concentration in serum usually occurs after 1 hour of taking the drug (after a standard meal, in healthy people volunteering).

Body activity is determined about 60-70% and the half-life of plasma cancellation is 1.3 +/- 0.3 hours. It is possible to detect the drug until 8 hours after absorption but it is very strong, so it does not see the freelance ingredient in the urine.

Spironolactone combined with protein is about 98% but the drug distribution is unknown. The level of drug accumulation in tissue and the ability to drug through the bloody barrier is also unknown.

The main location of spironolactone biological metabolism is thought to be in the liver.

Furosemide

The reference method to determine the concentration of Furosemide in plasma and urine is the method of gas-fleeting chromatography and high-performance liquid chromatography. When using Furosemide oral form in healthy people, the average biological activity of the drug is about 52% but the EHE is 27 - 80% wide. It seems that there is no significant metabolism before. Food reduces the biological activity of Furosemide by about 30%.

In plasma, Furosemide combined with protein, mainly albumin. Furosemide's distribution volume changes in the range of 170 - 270 ml/kg.

When Furosemide concentration is determined by special methods, the half-life of phase B changes in about 45-60 minutes. Furosemide clearance in plasma is about 200ml/min.

Excretion through the kidneys in the form of unchanged, removing drugs by metabolism and waste through feces. Furosemide is partially filtered in the kidneys in the form of glucuronide.

Furosemide can pass each other, in pregnant mothers with edema and high blood pressure. The concentration of drugs in infant plasma may be equivalent to the concentration of drugs in the mother's plasma. Furosemide secreted in milk.

The biological activity of Furosemide is taken orally in patients with heart failure, but may reduce the clearance in these patients. In patients with progressive renal failure, the biological activity of the drug decreased and reduced the removal of drugs in plasma, the half -life lasted about 9 hours in patients with increased blood urea.

In humans, Furosemide is partially converted into an inactive form -Glucuronide 7-15%, and is excreted by surface and urine.

Before taking Spiromide 20/50mg Search decreased edema, diuretic, hypotension (2 blisters x 10 tablets)

How to use

oral spiromide.

Dosage

recommended dose: Take 1-4 tablets/day (50-200 mg Spironolactone and 20 - 80 mg Furosemide) depending on the response of the patient.

Maximum effect occurs after a few days of medication.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Increase K+ blood and lower Na+ rare blood occurs. Symptoms often lose when stopping drugs, compensation and electrolytes, appropriate hypertension treatment.

High doses of Furosemide can cause loss of fluid and severe electrolytes, causing a decrease in internal volume, which can cause vertical hypotension and glomerular filtration.

Reducing the volume due to Furosemide will activate the renin-angiotensin-aldosterone system and this way K+ takes a lot through urine. Treatment includes additional NaCl and water, if necessary intravenously.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Spiromide 20/50 you may experience unwanted effects (ADR).

There may be large breasts in men when using spironolactone, and physicians should have a warning to patients with this possible effect. The appearance of large breasts may be related to the dose. and treatment time and often go away when stopping spironolactone.

Some rare cases may have persistent breasts.

Other adverse reactions, usually all when discontinued, has been recorded, including: impotence, stomach disorders, sleeping, rash, menstrual disorders and mild androgen effects.

Furosemide can cause hyperur with hyperuria, hyperuricemia and hyperglycemia. Bone marrow decline is a rare complication of Furosemide, need to stop treatment.

Dermatological reactions have been recorded when using Furosemide, including urticaria, diverse erythema, hemorrhage, flaking dermatitis, itching, necrotic vasculitis, skin blistering due to toxic reactions to light.

Furosemide blood disorders include anemia, granulocytosis and thrombocytopenia.

Rarely interstitial nephritis and acute pancreatitis.

Other adverse reactions, often all when stopping using Furosemide has been reported, including: tinnitus and deaf recovery, paresthesia, blurred vision, hypotension, stomach-intestinal disorders.

Notify the doctor the unwanted effects when used.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

SPIROMIDE drug is contraindicated in the following cases:

Acute renal failure, significantly reduced renal function, anuria, hyperkalemia and patients with a history of hypersensitivity to any component of the drug.

Pregnant, lactating and children.

Precautions when used

Be cautious when using supplements with potassium supplements or other potassium -containing drugs because it can cause hyperkalemia.

Need to adjust the dose of heart glycoside and anti -blood pressure drugs when adding spiromide to the treatment regimen.

Sulfonamide derivatives, including Furosemide, have reported reports to worsen or activate systemic lupus erythematosus.

It is necessary to periodically assess the serum electrolytes due to the ability to increase potassium, hypoglycet hematoma, alkaline chlorinated chlorine and may have a transient bun, especially in patients with kidney function damage. If there is hyperkalemia, stop taking the drug and take positive measures to reduce serum potassium levels to normal levels. Combined with the diuretics, Spiromide may increase the concentration of uric acid in the serum and worsen gout.

Be cautious in patients with severe liver disease and too strong diuretic treatment can worsen liver brain disease in sensitive patients.

There have been a few cases where blood glucose increases and changes in glucose tolerance. Periodically check blood glucose and urine in diabetics and in people suspected of diabetes when treated with spiromide.

Furosemide increases the risk of urinary urination in patients with prostate disorders and/or there is an urination function damage. The metabolic acidosis has been recorded for a hemorrhage in some liver disease.

Spironolactone or its metabolites can be through the placenta and the safety of Furosemide in pregnant women in the beginning has not been set. Therefore, only spiromide in pregnant women when the benefits gain is greater than the risk for the mother and the fetus.

canrenone (metabolites of spironolactone) and Furosemide in breast milk. Furosemide inhibits milk secretion. If you need spiromide treatment in breastfeeding women, it is necessary to feed your baby outside.

The ability to drive and operate machinery

There is no record information.

Pregnancy

Spironolactone or its metabolites can be through the placenta and the safety of Furosemide in pregnant women in the beginning has not been set.

Do not use drugs for pregnant women because Furosemide through the placenta, the drug also reduces the amount of blood to the uterus. Only use Spiromide in pregnant women when the benefits are greater than the risk for the mother and the fetus.

Breastfeeding period

Canrenone (metabolites of spironolactone) and Furosemide in breast milk. Furosemide inhibits milk secretion. If you need spiromide treatment in breastfeeding women, it is necessary to feed your baby outside.

Medicinal interaction

Furosemide and Salicylate competing in the excretory position in the kidney, so patients taking high doses of salicylate may have Salicylate poisoning.

Furosemide has an antagonistic tubocurarine effect and can enhance the effects of sucinylcholine. Both Spironolactone and Furosemide reduces the circuit wall response to norepinephrine. Therefore, cautious when used in patients with body anesthesia or local anesthesia.

Lithium's kidney clearance is reduced by Furosemide, which can lead to an increased risk of lithium poisoning.

Not simultaneously used cephaloridine with Furosemide for reporting a report on kidney toxicity.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.