Spiromide 40 Searle diagnosed and treated primary Aldosterone (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Spironolactone, Furosemide

Ingredient

Composition information	Content
Spironolactone	50mg
Furosemide	40mg

Uses

Indications

Spiromide 40/50 is indicated in the following cases:

Diagnosis and treatment of integer Aldosterone (adrenal adrenal tumor secreted Aldosterone, increased the adrenal glands on both sides).

Treatment of high blood pressure must take medicine.

Surprised edema is caused by secondary Aldosterone, and anti -anti -anti -anti -tumor treatments for oral or veins.

Adjusting potassium and/or magnesi due to the previous use of gay gay potassium.

Pharmacy

Spironolactone is the most important steroidal lactone in clinical application: it acts as a diuretics and low pressure by Aldosterone's inhibition effects, and partial inhibition of adore cortisol biosynthesis of Aldosterone.

pharmacokinetic

spironolactone

Spironolactone is absorbed through the digestive tract, reaching the maximum concentration in the blood after 1 hour, but still with the concentration that can be measured at least 8 hours after 1 dose. Relative bioavailability is over 90% compared to the bioavailability of Spironolacton solution in polyethylene glycol, the best absorption. Spironolacton and its metabolites are excreted mainly in urine, partly through bile.

Furosemid

Furosemid is well absorbed by oral, diuretic effects appear quickly after 1/2 hours, reaches the maximum concentration after 1-2 hours and maintains the effect from 6 - 8 hours. Anti -hypertension effect is longer. Furosemid's absorption can be extended and can be reduced by food. One third of the absorption drug is excreted through the kidneys, the rest is eliminated through the urine, mainly in the form of non -metabolic, completely excreted drugs for 24 hours. Furosemid passed the placenta fence and into breast milk.

Before taking Spiromide 40 Searle diagnosed and treated primary Aldosterone (3 blisters x 10 tablets)

How to use

Spiromide is used orally. To increase biological activities, use Spironolactone with meals.

Dosage

Spironolactone dose varies depending on clinical disease.

In the treatment of secondary Aldosterone or high blood pressure, 50 - 100 mg/day, the dose can be increased to 400 mg/day in diagnosis and treatment of primary Aldosterone. The maximum effect occurs after a few days of medication.

With oral Furosemide usually starts at a dose of 20 - 40 mg/day, 1-3 times/day, and increases the dose depending on the treatment response. In general, oral doses from 160 - 320 mg/day and not exceeding this dose. However, in patients with renal failure, oral doses can reach 1000 mg/day. In children, orally 1 - 3 mg/kg/day.

Venous treatment usually starts at a dose of 20-40 mg used once to 2 times/day. Depending on the response of the treatment, it may increase the dose as the dose treatment. Especially in patients with progressive renal failure, bureaucracy increases to 1000 mg of Furosemide/day that can be used in intravenously. To avoid toxicity on the ear, the transmission speed should not exceed 4 mg/min.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Increase K+ blood and lower Na+ rare blood occurs. Symptoms often lose when stopping drugs, compensation and electrolytes, appropriate hypertension treatment.

High doses of Furosemide can cause loss of fluid and severe electrolytes, causing a decrease in internal volume, which can cause posture lowering and reducing glomerular filtration.

Reducing the volume because Furosemide will activate the Renin - Angiotensin - Aldosterone system and this way K+ takes a lot through urine. Treatment includes additional NaCl and water, if necessary intravenously.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using the drug, you may experience unwanted effects (ADR).

Like other drugs, Spiromide 40 also causes some unwanted effects related to the two main ingredients of the drug, but most cases recover when stopped treatment:

For Spironolactone: Prostate hypertrophy, progression of mammary hypertrophy in men. Hyperglycemia, bone marrow inhibition, jaundice, pink, dermatitis, skin bleeding are also recorded as the side effects of the drug.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

SPIROMIDE drugs are contraindicated in the following cases:

hyperboly in the blood.

Caution when using

Follow the doctor's instructions, pay attention to drug interactions and read the instructions carefully before use.

This drug has no tendency for babies.

The ability to drive and operate machinery

Spiromide 40 has no recognition about the impact on the ability to drive and operate machinery.

Pregnancy

Spironolactone through the placenta, so the most ideal is not for pregnant women.

Furosemide through the placenta, it also reduces the amount of blood in the uterus - the placenta. So avoid using Furosemide during pregnancy if not really needed.

Breastfeeding period

Spironolactone is contraindicated while breastfeeding.

Furosemide through breast milk. Do not breastfeed when mothers are being treated with Furosemide. Furosemide also inhibits milk secretion.

Drug interaction

Interactions can be dangerous

Aspirin: Aspirin reduces carenone secretion into urine. Furosemide is often used with other drugs, especially in the elderly, and some important interactions must be set. Triamterene and carbenoxolone. Spironolactone acts with lithium in mental patients.

Model interactions may be beneficial

In some previous disorders described, when combined with Spironolactone with other diuretics increases gift signs more than each use. When coordinating Furosemide with other antihypertensive drugs increases the effect of high pressure treatment.

side effects

Be life -threatening effects:

Detects breast cancer in patients using prolongolactone, but this particular relationship has never seen and it seems that it has another cause as an opportunity. It can cause hygiene of blood and hypoglycemia, worse renal function, especially in people with the previous renal function. Increased severity of K+ blood causes death when using Spironolactone combined with enzyme inhibitors in the treatment of patients with high blood pressure or heart failure that reduces the average renal function.

Gastrointestinal disorders:

Peptic ulcer, black stool. Furosemide is similar to other diuretics that cause Mg ++ eye, which can cause arrhythmia. The deficiency of both K+ and Mg ++ tends to occur in older patients who eat poorly or not adequate nutrition when feeding with intravenous sugar. K+ gums that keep K+ also reduce the deficiency of Mg ++ due to diuretic. Furosemide is less tolerant than the tolerance of Thiazides. Furosemide deaf often asks for the drug. However, there are also cases of not toxic toxicity in the ear. This side effect is common in patients with renal failure and is treated with intravenous, high doses. This risk increases when treating Furosemide in combination with aminoglycoside antibiotics.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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