SPLOZARSIN Plus Shinpoong Deawoo Treatment of Hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Losartan, hydrochlorothiazide

Ingredient

Composition informationContent
Losartan50mg
Hydrochlorothiazide12.5mg

Uses

Indications

Treatment of hypertension for patients need to combine drugs, reduce the risk of cardiovascular complications for patients with hypertension with left ventricular hypertrophy.

Pharmacokic

Losartan is the first substance of the new anti -hypertension drug group, which is an antagonistic antagonist (Type AT1) Angiotensin IL. Angiotensin II antagonists also have hemodynamic effects such as ACE inhibitors, but there is no unwanted effect of the common ACE inhibitors are dry cough.

hydrochlorothiazid and thiazid diuretics increase the secretion of sodium chloride and water attached to the mechanism of inhibiting the reabsorption of sodium and chlorine ions in the distance. Hydroclorothiazid has the effect of lowering blood pressure, which is probably due to a decrease in plasma volume and extracellular fluid related to sodium urine. Hydrochlorothiazid's hypotension effect is slowly shown after 1-2 weeks, while diuretic effects occur quickly and can be seen right after a few hours. Hydrochlorothiazid increases the effects of other antihypertensive drugs.

Dynamic pharmacokinetics

losartan

absorption

After drinking, Losartan absorbs well and initially metabolizes the liver thanks to the cytochrom P450 enzymes.

Distribution

Losartan's bioavailability is approximately 33%.

Metabolism

About 14% of the losartan dose is transformed into active metabolites, this substance is mostly antagonist antagonist Angiotensin II.

Elimination

The half -life of Losartan elimination is about 2 hours, and of the metabolite for about 6-9 hours. The average peak concentration of Losartan is within 1 hour, and of specialized chemicals within 3-4 hours.

hydrochlorothiazid

absorption

After taken, hydrochlorothiazid is relatively fast, about 65 - 75% of the dose of use, but this ratio may decrease in heart failure people.

Distribution

hydrochlorothiazid accumulated in red blood cells. Hydrochlorothiazid passes through the placenta, distributed and reaches high concentrations in the fetus. The diuretic effect appears after drinking 2 hours, reaching a maximum after 4 hours and lasts about 12 hours. Hypotension effects are much slower than diuretic effects and can only achieve adequate effect after 2 weeks, even with the optimal dose between 12.5 - 25 mg/day. It is important to know that the hypotension effect of hydrochlorothiazid is usually optimal at the dose of 12.5 mg (half of 25 mg).

Elimination

Mainly eliminated drugs through the kidneys, mostly in the form of non -metabolic. Half of the lifetime of hydrochlorothiazid is about 9.5 - 13 hours, but it lasts in case of renal failure so the dose should be adjusted.

Before taking SPLOZARSIN Plus Shinpoong Deawoo Treatment of Hypertension (3 blisters x 10 tablets)

How to use

Anti -hypertension effect will be achieved within the first 3 weeks of treatment.

Can combine other hypertension medications.

Can be taken or not in common with food.

Dosage

Initial dose and maintenance dose: 1 tablet/day.

For people who do not respond, the dose may increase: 2 capsules x 1 time/day. The maximum dose per day is Losartan 100 mg/hydrochlorothiazide 25 mg or 2 tablets/day.

Elderly: The starting dose is 1 tablet/ day, do not take 2 tablets/ day is the starting dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Treatment is symptomatic and supportive. Need to stop the drug immediately and monitor the patient period. The measures to be recommended are vomiting if they have just taken medicine, rehydration, electrolyte balancing, liver coma treatment, handling of blood pressure reduction according to normal processes.

losartan:

Data overdose in people is limited. The most common expression of overdose is probably hypotension and tachycardia; It is also possible to experience a slow heartbeat due to sympathetic stimulation (vagus nerve). If symptomic hypotension occurs, supportive treatment must be treated. Both Losartan and metabolites are active, they cannot be removed by hemolysis.

hydrochlorothiazid:

Mainly manifestations are water and electrolytes due to a lot of excess. If using digitalis, hypoglycemia increases arrhythmia.

Handling: Gastric lavage when using medication, using activated carbon. Anti -alkaline blood: Use chloride unless patients with liver disease. In return, quickly the amount of water and electrolytes have been lost. Peritoneal can be separated to adjust water and electrolyte balance. In the case of hypotension without responding to the above interventions, using 4 mg/liter norepinephrine 4 mg/liter intravenously or dopamine with the initial dose of 5 micrograms/kg/minute.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

  • Nervous system: dizziness.
    • Systemic: weakness, fatigue, dizziness.

    Uncommon, 1/1000

  • No report.

    • Not determined frequency

  • The immune system: hypersensitivity (anaphylactic reaction, lip, throat and/ or tongue, vascular inflammation, Henoch-schoenlein).
  • Digestive system: hepatitis, diarrhea.
  • Respiratory system: HO.

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    contraindicated

    hypersensitivity to losartan, thiazid diuretic and sulfonamid derivatives or any ingredients of the drug.

    Gout, hyperuricemia, urology, Addison disease, hypercalcemia, liver and kidney failure.

    Be cautious when using

    Special monitoring and/ or decreased dose in patients dehydration, diuretics and patients have other factors to lead to lowering blood pressure, patients with kidney stenosis or only one kidney.

    Periodically monitor electrolytes in serum and urine, especially patients using corticosteroids, acth hodc digitalis, quinidin (risk of curly causing vibration).

    Severe kidney failure: increased blood urea and may reduce the kidney function.

    Snacking: prone to liver coma.

    gout: severe illness.

    Diabetes: Pay attention to adjusting the drug (insulin, hypoglycemic drugs).

    Hypotension effect of hydrochlorothiazid increases in patients after removing sympathetic nerve.

    hyperka cholesterol and triglycerides in the blood. Note when taking drugs in the elderly because it is easy to imbalance electrolytes.

    The ability to drive and operate machinery

    There is no reporting document. However, it is necessary to be cautious when driving and operating machinery because the drug can cause dizziness, dizziness, especially when starting to use the drug, or when increasing the dose.

    Pregnancy

    Losartan in the middle and the last three months of pregnancy can cause less amniotic fluid, hypotension, anuria, urinary discharge, face deformation and death in infants. Although, the use of drugs in the first three months of pregnancy has not seen the risk of the fetus, but when detected pregnancy, Losartan must be stopped as soon as possible. Thiazid diuretics are all pregnant into the fetus, causing electrolytes, thrombocytopenia and jaundice in newborns. So do not use this group of drugs in the last 3 months of pregnancy.

    The period of breastfeeding

    It is unknown whether Losartan is secreted into breast milk, but there are significant amounts of Losartan and the active metabolitus of the culvert of the culvert; Hydroclorothiazid goes into breast milk with the amount that can be harmful to the child and inhibit milk secretion. Therefore, it is necessary to consider not using medication or stop breastfeeding depending on the degree of need for the drug for the mother.

    Drug interaction

    losartan:

    Losartan does not affect Digoxin's dynamics.

    Cimetidine increases the area under the curve (AUC) of Losartan by about 18%, but does not affect the pharmacokinetics of the metabolites with the activity of Losartan.

    Phenobarbital Lam reduced by about 20% of Losartan's AUC and the active metabolites.

    hydrochlorothiazid:

    can interact with: alcohol, barbiturates or addictive sleeping pills; Drugs to treat diabetes; other hypotension drugs; corticosteroid, ACTH; Amines hypertension (eg norepinephrin); Muscle relaxants (eg tubocurarin), lithium; nonsteroidal anti -inflammatory drugs; Quinidin; anticoagulant drugs, gout medicine; Anesthesia, glycosid, vitamin D; cholestyramin or colestipol.

    Storage

    In closed packaging, in a dry place temperatures below 30 ° C.

    Other drugs

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