Srinron 10g skin cream Mipharmco treats skin diseases due to infections or fungi, combination skin diseases

Dosage form Box x 10g
Specifications Clotrimazole, betamethasone dipropionate, Gentamicin

Ingredient

Composition information	Content
Clotrimazole	100mg
Betamethasone dipropionate	6.4mg
Gentamicin	10mg

Uses

indications

Srinron drugs are indicated in the following cases:

Used in common skin diseases due to infections or fungi, mixed skin diseases, contact dermatitis, allergic eczema, chronic otitis, candidiasis and Napkin rash. Trichomonas, Staphylococcus and Bacteroides. No effect on lactobacilli.

The mechanism of acting of clotrimazol is to link with phospholipids in the fungal cell membrane, changing the permeability of the membrane, causing loss of intracellular essential substances leading to the destruction of mushroom cells.

Invitro, Clotrimazol have the effect of restraining and killing fungi, depending on the concentration, with Trichophyton Rugbrum, Trichophyton Mentagrophytop, Epidermophyton Flocosum, Microsporum Canis and Candida species. Natural resistance with rare clotrimazol. Only a strain of Candida Guillidondri resistant to clotrimazol resistance. Diagonal resistance between azol is popular.

betamethason is a synthetic corticosteroid, which has a very strong glucocorticoid effect, with negligible mineralocorticoid effect. 0.75 mg of betamethasone has an anti -inflammatory effect equivalent to about 5 mg of prednisolon.

betamethasone has anti -inflammatory, anti -rheumatic and anti -allergic effects. Drugs used oral, injected, injected, inhaled or applied to treat many diseases that need to be indicated to use corticosteroids, except for adrenal insufficiency states, prefer hydrocortison with Fludrocortison addition.

Due to the little effect of mineralocorticoid, betamethasone is very suitable in cases where the pathology that holds water is disadvantage. High doses, betamethasone has immunosuppressive effects.

Gentamicine Sulfate is an antibiotic of the aminoglycoid group that disinfects the bactericidal effect through inhibiting bacterial protein biosynthesis. The actual gentamicine antibacterial spectrum includes Gram -negative aerobic bacteria and staphylococcus aureus, including strains producing penicillinase and methicilin resistance.

Gentamicine has little effect on gonorrhea, streptococcal, steering cells, meningococcal brain, citrobacter, Providencia and Enterococci. Mandatory anaerobic bacteria such as bacteroides, clostridia are all resistant to Gentamicine.

Dynamic pharmacokinetics

Used on the skin or vaginal use, Clotrimazol is very few absorbed. Six hours after applying the cream and solution of 1% Clotrimazol radioactive on the skin intact and on acute inflammatory skin, clotrimazol levels vary from 100 micrograms/cm3 in the horny layer to 0.5 - 1 microgram/cm3 in spikes and 0.1 micrograms/cm3 in subcutaneous tissue layer.

Betamethason is easily absorbed through the gastrointestinal tract. The drug is also easy to absorb when used on the spot. When applied, especially if the skin is torn or when the skin is torn or when the rectum, there may be a amount of betamethasone that is absorbed enough for the whole body effect. The type of betamethasone -soluble betamethasone is used intravenously for quick response, the form of soluble in intramuscular lipids will last longer.

betamethason quickly distributed into all tissues in the body. The drug through the placenta and can be exported to breast milk in small amounts.

During the circulation, Betamethason is widely linked to plasma proteins, mainly globulin and less. Synthetic corticosteroids include betamethason, less spacious links with protein than hydrocortison. Their half -life has a longer tendency.

betamethason is a prolonged glucocorticoid. The corticosteroids are metabolized mainly in the liver but also in the kidneys and the issue into the urine. The metabolism of synthetic corticosteroids, including betamethasone, is slower and their protein bonding is lower, which can explain more powerful than natural corticosteroids.

Gentamicine sulfate is not absorbed through the gastrointestinal tract. Gentamicine is used intravenously or intramuscularly. For people with normal renal function, after 30 to 60 minutes of injection 1mg/kg body weight, plasma peak concentration reaches about 4 micrograms/ml, like the concentration of postal intravenous injection. The drug is less attached to plasma proteins.

Gentamicine diffuses mainly on extracellular fluids and easily diffuse into foreign ears.

The half -life of Gentamicine plasma is from 2 to 3 hours, but can last for infants and kidney failure. Gentamicine is not metabolized and eliminated (almost unchanged) through the urine through the glomerular filtration. In a stable state, at least 70% of the dosage is produced in the urine for 24 hours and the concentration of urine can exceed 100 micrograms/ml. However, Gentamicine accumulated to some extent in the body's tissues, especially in the kidneys.

Before taking Srinron 10g skin cream Mipharmco treats skin diseases due to infections or fungi, combination skin diseases

How to use

topical drugs.

Dosage

Apply a sufficient amount of drugs to the sick skin, 2 times/day. If the disease does not help after 4 weeks of treatment, it is necessary to review the diagnosis. The disease usually supports within 1 week. Sometimes treatment for up to 8 weeks.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, there are common unwanted effects (ADR) such as:

Local reactions (> 1%) include minor burns, irritation, allergic dermatitis due to contact, burning pain.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Srinron drugs contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

If there is irritation or sensitivity when taking the drug, the medication must be stopped and treated appropriately. After 4 weeks of treatment, if not supported again.

The effect of the drug on the ability to drive and operate machinery

has not found documents in the pharmacy.

Using drugs for women during pregnancy and lactation

Pregnancy: Only use the drug when really necessary.

Breastfeeding period: Only use the drug when really necessary.

Drug interaction

reduces the activity of gentamicine: Ca, Sulfafurazol, Heparin, Sulfacetamid, Mg, Acetylcystein, Cloramphenicol, Actinomycin, Doxorubicin, Clindamycin.

Storage

Store at temperatures below 30 ° C. Cool dry place, avoid light.

Other drugs

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