Stacytine 200 cap Stella treats sputum in bronchitis (10 blisters x 10 tablets)

Code ATC: R05cb01

Acetylcysteine ​​is the n-acetyl derivative of L-cystein natural amino acid. Acetylcysteine ​​reduces the viscosity of pus and no pus by breaking the disulfid bridges in mucoprotein and facilitates the sputum with cough, posture or mechanical method. The sputum effect of the drug depends on the free sulfhydryl group, which is capable of reducing the Disulfid links of Mucoprotein through the exchange reaction, forming a combined disulfid group and a free sulfhydryl group.

Acetylcysteine ​​can protect the liver too much Paracetamol by maintaining or restoring glutathion concentration or acting as a substrate that is associated with toxic intermediate metabolites.

pharmacokinetics

acetylcysteine ​​is quickly absorbed through the gastrointestinal tract and the peak concentration in plasma is reached in the range of 0.5 - 1 hour after the dose of oral 200 - 600 mg.

Low oral bioavailability and average value between 4 to 10% depend on total acetylcysteine ​​form or only based on reducing form. Low oral bioavailability of low acetylcysteine ​​may be metabolized through the intestinal wall and metabolized through the liver for the first time. The kidney clearance accounts for about 30% of the whole body clearance. The last elimination time of acetylcysteine ​​is 6.25 hours.

The first dose of 140 mg/kg, used in 5%solution; Next every 4 hours, dose of 70 mg/kg body weight and total added 17 times. Acetylcysteine ​​is announced to be very effective when used within 8 hours after paracetamol overdose, the protection effect is reduced after that time. If the treatment is started slower than 15 hours, it is not effective, but the recent studies think that it is still useful.

(*) Hard -made cysts are not suitable for children under 3 years of age, recommend the appropriate use of dosage.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Especially hypotension; Other symptoms include respiratory failure, hemolysis, scattered intravascular coagulation and kidney failure, but some of the above symptoms may be caused by paracetamol poisoning.

There is no antidote. Should take common support measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Be cautious when using

When taking acetylcysteine ​​to treat paracetamol overdose can lead to vomiting or severe vomiting, patients at risk of gastric bleeding should be considered between the risk of gastrointestinal bleeding with the liver toxicity of paracetamol to have the direction of using acetylcysteine.

Hen patients when taking acetylcysteine ​​must be closely monitored during the treatment process; When bronchospasm occurs, bronchodilator spraying must be used. If bronchospasm still progresses, it is necessary to stop acetylcysteine ​​immediately.

When treated with acetylcysteine ​​may appear a lot of diluted phlegm in the bronchi. If the patient reduces the ability to cough, must suck mechanically or place the straw in the trachea to clear the airway for the patient.

Patients with hepatic impairment: The total clearance of Acetylcysteine ​​is significantly reduced in cirrhosis patients and the semi -waste time is almost twice as higher than that of healthy people.

Stacytine 200 cap contains lactose excipients. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or poorly absorbed glucose-galactose.

Stacytine 200 cap contains starch, patients allergic to wheat (unlike Coeliac disease) should not be taken.

The ability to drive and operate machinery

Unknown the effect of the drug on the ability to drive and operate machinery.

Pregnancy

Paracetamol overdose treatment with acetylcysteine ​​in pregnant women is effective, safe and able to prevent the toxicity of the liver in the fetus as well as in the mother.

Breastfeeding period

The drug is used for nursing mothers.

Drug interaction

Drug interaction

Acetylcysteine ​​is a reducing agent that should be similar to oxidants.

Do not simultaneously use other cough or any drugs that reduce bronchial secretion during acetylcysteine ​​treatment.

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.