Stadeltine 5mg Stella drugs reduce symptoms in the eye and nose (5 blisters x 10 tablets)

pharmacokinetics

absorption:

levocetirizine is absorbed quickly and after drinking. In adults, the peak concentration of plasma is about 0.9 hours after drinking. Stable state achieved after 2 days. The peak concentration of the drug is 270 ng/ml and 308 ng/ml when using a single dose and the dose repeats 5 mg once daily.

The absorption level of the drug is not a dose depend on the dose and is not affected by food, but the food reduces the peak concentration and slows the time to reach the peak concentration.

Distribution:

There is no data distribution in human tissue and passing through the bloody barrier of levocetirzine. In rats and dogs, the highest concentration in the liver and kidneys, the lowest concentration in the central nervous system.

Levocetirizine's plasma protein binding ratio is 90%. The distribution capacity of the drug is poor with the distribution volume of 0.4 I/kg.

Metabolism:

Levocetirizine's metabolism in humans is less than 14% of the dose, so the difference due to genetic polymorphism or when used simultaneously with enzyme inhibitors is considered negligible. The metabolic paths are aromatic oxidation, reducing alkyl n-and o- and conjugated with taurin. The alkyl group reduction path is mainly through CYP3A4 intermediaries while the aromatic oxidation is associated with complex CYP forms and/or CYP has not been determined. Levocetirizine does not affect the ISOENZYM CYP 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 at a higher concentration of the peak concentration after taking the dose of 5 mg. Due to slow metabolism and without the potential to inhibit metabolism, the interaction of levocetirizine with other substances or vice versa does not occur.

Era:

Levocetirizine's sale time in adults is 7.9 ± 1.9 hours. The sale time in children is shorter than in adults. The main elimination of levocetirizine and metabolites are through urine, accounting for an average of 85.4% of the dose. The amount of drug excreted in feces only accounts for 12.9% of the dose. Levocetirizine is eliminated through both glomerular filtration and active excretion through the renal tubules.

kidney failure:

The apparent clearance of levocetirizine is correlated with creatinine clearance. Therefore, it is recommended to adjust the distance between levocetirizine doses based on creatinine clearance in medium and severe renal failure patients. At the end of the anuria in patients with renal failure, the body clearance decreases by about 80% compared to normal people. Less than 10% of levocetirizine is removed during the process of blood decomposition in 4 hours.

Pediatric insufficiency: Dosage should be adjusted depending on the patient based on the child clearance, age and weight of the child.

Patients with liver failure: No dose adjustment for patients with only liver failure.

Patients with liver and renal failure: Adjust the dose as recommended.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Observatory symptoms used after overdose of levocetirizine are mainly related to the effects on the central nervous system or effects related to the antivolinergic effect. The unwanted effects are recorded after taking at least 5 times the recommended daily dose: Confusion, diarrhea , dizziness, fatigue, headache , discomfort, pupils, itching, restlessness, sleepy, sleepy, fast heartbeat, tremor and urinary retention.

Overdose treatment:

There is no specific antidote for levocetirizine. If an overdose occurs, it is recommended to treat symptoms or support. It is necessary to consider gastric lavage if the patient only takes medication in a short time. Levocetirizine is not eliminated by dialysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Be cautious when using

do not recommend for children under 6 years old because there is still no response to film tablets.

Caution with patients with epilepsy or patients at risk of seizures.

Patients should be cautious about dangerous things that need complete mental alertness and movement coordination such as operating machinery or driving after using levocetirizine.

Should avoid simultaneous use of levocetirizine with alcohol or central neurological inhibitors because it can reduce alertness and weaken the activity of the central nervous system.

Stadeltine contains lactose. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or glucose-galactose.

The ability to drive and operate machinery

Comparative clinical studies have confirmed that there is no evidence of levocetirizine at the recommended dose to reduce mental alertness, reaction ability and driving ability. However, some patients have cards with chicken sleep, fatigue and weakness when using levocetirizine. Therefore, when intending to drive, carry out potential risk activities or operate the patient's machines should monitor the body's reaction to the drug.

Pregnancy

There are no complete and well -controlled studies in pregnant women. Because animal reproduction studies do not always predict human being, levocetirizine should only be used during pregnancy if really necessary.

breastfeeding period

There is a levocetirizine report on milk. Therefore, it is not recommended to use levocetirizine during breastfeeding.

Interactive drug

There are no studies on Intervoing In Vivo, which has been done with levocetirizine.

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.