Stadexmin Stella medicine treats respiratory, skin and eye allergy (500 tablets)

Dosage form Box of 500 capsules
Specifications Betamethasone, dexchlorpheniramine maleatamine

Ingredient

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Composition informationContent
Betamethasone0.25mg
Dexchlorpheniramine maleaty2mg

Uses

Indications

Stadexmin drug are indicated for treatment of complex cases in the respiratory tract, skin and eye allergy, as well as eye disorders, diseases that need to be indicated for additional corticosteroid therapy.

Pharmacokological

stadexmin combines two anti -inflammatory and anti -allergic effects of corticosteroids, betamethasone, a derivative of presnisolon and antihistamine effects of dexclorpheniramine malt. Combining betamethason and dexclorpheniramin maleat allows the reduction of corticosteroids and still obtained the same effect when using only corticosteroids at higher doses.

betamethason is a synthetic corticosteroid, with the main glucocorticoid effect. 0.75 mg of betamethasone has an anti -inflammatory effect equivalent to about 5 mg of prednisolon. Betamethasone has anti -inflammatory, anti -rheumatic and anti -allergic effects. Due to less mineralocorticoid effect, Betamethasone compression is very suitable in diseases that retain water is disadvantage.

Dexclorphenramin Maleat is an antihistamine with very little sedative effects. Like most other histamine drugs, dexclorpheniramine Maleat also has side effects against acetylcholin secretion, but this effect varies greatly among individuals. The antihistamine effect of dexclorpheniramin maleat through the closing body of the H1 receptors of the acting cells.

pharmacokinetic

betamethason

absorption

Batamethason is easily absorbed through the gastrointestinal tract.

Distribution

betamethason quickly distributed into all tissues in the body. The drug through the placenta and can be exported to breast milk in small amounts. During the circulation, Betamethason is widely linked to plasma proteins, mainly with globulin and less. Synthetic corticosteroids (including betamethason) linked to protein less than hydrocortison; Betamethatson is a long -lasting gluccocorticoid. Their selling time also tends to be longer.

Metabolism and elimination

corticosteroids are metabolized mainly in the liver but also in other tissues and the exit into the urine. The metabolism of synthetic corticosteroids (including betamethason) is slower and their protein bonding is lower, which can explain more powerful than natural corticosteroids.

dexclorpheniramin maleat

absorption

Dexclorpheniramin Maleat is relatively slowly absorbed through the digestive tract, the plasma peak concentration is about 2.5 - 6 hours after drinking. Low bioavailability, reaching 25-50%. The impact time period is 4 - 6 hours, shorter than the prediction from pharmacological parameters.

Distribution

About 70% of the drug during the circulation is linked to the protein. Dexclorpheniramin Maleat is widely distributed in the body and enters cerebrospinal fluid.

Metabolism and elimination

dexclopheniramin maleat is significantly metabolized through the liver for the first time. There are great differences between the pharmacokinetic individuals of dexclorpheniramin maleat; The sale time is valid from 2 - 43 hours. Dexclorpheniramin Maleat is greatly metabolized. Metabolic substances include desmethyl and dismethylclorphenamine. The drug is in a constant form and the metabolic is excreted mainly in the urine, the excretion depends on the pH and the urine flow. Only a small amount is found in feces.

Before taking Stadexmin Stella medicine treats respiratory, skin and eye allergy (500 tablets)

How to use

Take oral use.

Dosage

Dosage depends on each individual and adjusted to suit each separate disease treated, the degree of disease and the response of the patient.

Adults and children> 12 years old:

recommended starting dose: 1-2 capsules 4 times/day, after eating and sleeping. Do not use more than 8 tablets/day.

In younger children, adjust the dose to suit the level of disease and the response of the patient rather than based on age or weight.

Children from 6 to 12 years old:

1/2 tablets 3 times/day. If you need one more daily dose, it is best to drink at bedtime. Do not use more than 4 tablets/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

  • The overdose reaction of conventional antihistamine drugs may change from the inhibition of the central nervous system (sedation, suffocating, reducing mental alertness, purple blue, arrhythmia , cardiovascular traceability) to irritation (insomnia, hallucinations, tremor, convulsions) to death. Pressure. hallucinations , loss of coordination and tougher -type - convulsions may occur. Single dose of Betamethason overdose does not cause acute symptoms. Unless the overdose is huge, a few days of excessive use of glucocorticosteroids probably do not cause harmful consequences, except for patients with special risks due to illness or simultaneous use of drugs with adverse interactive drugs with betamethasone.

    • Treatment:

  • Treatment of overdose is mainly symptomatic and supportive treatment.
  • Stimulants should not be used. to the balance of sodium and potassium. Treatment of electrolyte imbalance if necessary. However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    • Side Effects

    When using Stadexmin , you may experience unwanted effects (ADR).

    betamethason

    The undesirable effects of betamethason are related to both dose and treatment time. Like other corticosteroids, unwanted effects include water and electrolytes disorders, skeletal, digestive, skin, nervous, endocrine, eye and metabolism.

    Common, 1/100

  • Metabolism: Keep sodium and water, increase potassium elimination.
  • Endocrine: abnormal menstrual periods, syndrome cushing , slow growth in children, tolerance with glucose, diabetes manifestations.
  • Muscle muscle: muscle atrophy, muscle weakness, osteoporosis , pathological fracture, especially spinal rift, thigh bone necrosis.

    • Uncommon, 1/1000

  • Digestive system: peptic ulcer, perforation and gastrointestinal bleeding, acute pancreatitis.
    • nerve: refreshing, insomnia, agitation.
  • Eye: glaucoma or cataract.

    • Rare, 1/10000

  • Skin: acne, hemorrhage, bruising, him, slow scars.

    • Dexchlorpheniramin Maleat

    Common, 1/100

  • Central nervous system: Sleeping, sedation.
  • Digestive system: dry mouth.

    • Rare, 1/10000

  • Body: Dizziness.
  • Digestive system: Nausea.

    • Instructions on how to handle ADR:

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Stadexmin contraindicated in the following cases:

  • Patients with hypersensitivity to any ingredients of the drug.
  • 6 -year -old children.
  • Infants and children are lacking in months.
  • Patients who are taking Monoamin oxydase inhibitors (Mao).
  • Patients with body fungal infection.
  • Stomach ulcer, duodenum .
  • Narrow angle glaucoma.
  • Prostate hypertrophy or bladder neck.

    • Be cautious when using

    stadexmin contains lactose excipients. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or poorly absorbed glucose-galactose.

    stadexmin contains Azo group pigments such as Sunset Yellow and PonCeau 4R, which can cause allergic reactions.

    betamethason

    When using whole body corticosteroids must be very cautious in case of congestive heart failure, new myocardial infarction, hypertension, diabetes, epilepsy, glaucoma, hepatic discharge, osteoporosis, gastrointestinal ulcers, mental disorders and kidney failure. Children may increase their risk to some unwanted effects, in addition corticosteroids can cause growth. Elderly people may also increase the risk of unwanted effects.

    usually contraindicated corticosteroids in the event of an untreated bacterial infection with appropriate antibacterial chemotherapy. Patients who are taking corticosteroid therapy are more susceptible to infections, on the other hand, the symptoms of these diseases may be covered until late. Patients with tuberculosis progress or suspected tuberculosis must not use corticosteroids except in very rare cases used to supplement treatment with anti -tuberculosis drugs. Potential tuberculosis must be closely monitored and must be used to prevent tuberculosis, if corticosteroid therapy must be extended.

    The risk of chickenpox and maybe both shingles, increased in patients without immunity when using systemic corticosteroids, and patients must avoid contact with these diseases. Patients do not have immunity but exposure to chickenpox should be passive immunity. Similar caution is applied to measles. Do not use living vaccines for patients who are using high -dose corticosteroid therapy and at least three months later, can use dead vaccines or detoxify, although the response may decrease.

    During the long -term corticosteroid therapy, patients must be monitored regularly. Sodium and calcium and potassium addition may need to be reduced.

    dexchlorpheniramin maleat

    Due to the anti -acetylcholin secretion side effects of antihistamine drugs should be cautious in cases such as narrow -angle glaucoma, urinary retention, prostate proliferation, or colon garges.

    The sedative effect of dexchlorpheniramin maleat increases when drinking alcohol and when using co -exams with other sedatives.

    The drug can cause chickens, dizziness and mental impairment in some patients and can seriously affect the ability to drive and operate the machine. It is necessary to avoid being used for people who are driving and operating machinery.

    Use medication carefully with the elderly (> 60 years old) because these people often increase sensitivity to anti -secretion side effects.

    The ability to drive and operate machinery

    drivers and machinery operators should pay special attention to the risk of falling asleep when taking the drug, especially when the beginning of treatment. This phenomenon is evident when used with alcoholic or alcoholic drinks.

    Pregnancy

    Use stadexmin for pregnant women, or women of reproductive age requires consideration between treatment benefits and the ability to endanger mothers and fetuses. Children with mothers take significant doses of corticosteroids during pregnancy should be carefully monitored the signs of adrenal gland reduction.

    breastfeeding period

    Use stadexmin for breastfeeding women to consider the benefits of treatment and the ability to endanger mothers and babies.

    Drug interaction

    betamethason

    Simultaneously used with barbiturates, carbamazepin, phenytoin, primidon, or rifampicin can increase metabolism and reduce the treatment effect of corticosteroids.

    Patients taking both corticosteroids and estrogen should be monitored for corticosteroids.

    Use corticosteroids with diuretics that cause potassium loss, such as thiazid or furosemid, which can cause excessive potassium loss. Corticosteroids may increase the risk of hematuria when used simultaneously with amphotericin B or bronchodilators of Xanthin group or Beta2 transport drug owner. Simultaneous use of glucocorticoids with anticoagulants can increase or decrease anticoagulant effects.

    When combining nonsteroidal anti -inflammatory drugs with corticosteroids may increase the risk of bleeding and gastrointestinal ulcers.

    corticosteroids may reduce the concentration of salicylate in the blood.

    Glucocorticoid may increase blood glucose levels, patients with diabetes use simultaneously insulin and/or oral hypoglycemic drugs may have to adjust the dose when treated.

    dexchlorpheniramin maleat

    Mao inhibitors prolonged and increased the effects of antihistamine drugs, which can cause severe hypotension.

    Dexchlorpheniramin Maleat can increase the sedative effects of central neurological inhibitors such as alcohol, barbiturates, sleeping pills, opioid analgesic, sedative anxiety and anti -psychotic drugs.

    The correspondence of drugs

    Because there is no studies on the cavalry of the drug, does not mix this drug with other drugs.

    Storage

    Store in closed packaging, dry place, avoid light. The temperature does not exceed 30 ° C.

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