Stadnolol 50 Stella medicine for hypertension, chronic angina (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Atenolol

Ingredient

Composition information	Content
Atenolol	50mg

Uses

Indications

Stadnolol 50 drugs are indicated in the following cases:

Treatment of hypertension;

Stable chronic angina; Beta-commenergic body has a relatively selective (selective heart) without interior sympathetic nerve activity and membrane stability. With the effect of reducing sympathetic tone, Atenolol reduces heart rate, reduces heart contraction, reduces the speed of the atrial transcription and reduces the lenin activity in plasma. Atenolol can increase smooth muscle tone by inhibiting beta - 2. receptors.

pharmacokinetic

absorption

About 50% of Atenolol's oral dose is absorbed through the gastrointestinal tract. Although Atenolol is not metabolized for the first time through the liver, the whole body uses only about 50%. The time to reach the peak concentration in plasma is 2-4 hours.

Distribution

The ratio of plasma protein binding is about 3%. Relative distribution volume is 0.7 l/kg.

Metabolism

Atenolol is very small and does not form clinical and active metabolites.

Elimination

About 90% Atenolol in the circulation is eliminated in the form of unchanged with the kidneys within 48 hours. Atenolol's sale time is 6–10 hours in normal kidney function patients and can increase up to 140 hours in end -stage renal failure patients.

Before taking Stadnolol 50 Stella medicine for hypertension, chronic angina (10 blisters x 10 tablets)

How to use

Stadnolol 50 drugs for oral. Take medicine before meals.

Dosage

Hypertension

Atenolol's common starting dose in adults is 25–50 mg x 1 time/day. The adequate hypotension effect of Atenolol is achieved after 1-2 weeks.

can increase the dose up to 100mg x 1 time/day to achieve optimal response. Increasing atenolol dose above 100mg/day usually does not improve blood pressure control.

Angina

For the treatment of chronic stable angina, Atenolol's starting dose in adults is 50 mg x 1 time/day.

If not reached optimal response within 1 week, the dose should be increased to 100mg x 1 time/day.

arrhythmia

After controlled by Atenolol intravenously, the appropriate maintenance dose is 50–100 mg/day x 1 time/day.

Early treatment of acute myocardial infarction

Stadnolol 50 dose for adults: If the patient tolerates a total dose of 10 mg in injection of F cail can take 50 mg after 10 minutes of injection, 12 hours and then take an additional 50 mg.

Take it for 6–9 days at a dose of 100 mg/day, take 1 time or divide 2 times.

Stop Atenolol if the patient has a slow heart, hypotension or any unwanted effect of the drug.

Patients with renal failure

Should reduce the dose of Atenolol in patients with renal failure, based on the clearance of creatinine (CLCR) below:

CLCR 15–35 ml/min/1.73 m2: Atenonol's maximum oral dose is recommended for 50mg/day.

CLCR

Patient separating: 25 - 50 mg after each appraisal.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Can consider conducting hemorrhage or hemolytic transmission.

Excessive slow heart rate can be treated with Atropin 1–2 mg intravenously and/or using a pacemaker.

If necessary, intravenously (bolus) can add 10 mg of glucagon and can repeat or intravenously glucagon 1–10 mg/hour depending on the response. If not responded to Glucagon occurs or if there is no glucagon available, intravenously can be stimulated as a beta receptor like Dobutamine 2.5 - 10 mcg/kg/min.

Because Dobutamine has a muscle contraction effect, it can also be used to treat hypotension and acute heart failure. These doses may not be enough to regulate the heart effect of the beta receptor blocker if an overdose of a large amount of drug. Therefore, Dobutamine dose should be increased if necessary to achieve the desire depending on the patient's clinical condition.

Bronchospasm can be restored by bronchodilators.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Stadnolol 50 drug, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Systemic: weak muscles, fatigue, cold and chills.

Circulation: Slow heart rate, atrial atrial block II, III and hypotension.

Digestive: diarrhea, nausea.

Less, 1/10000

Sleep disorders, sex reduction.

Rare, 1/1000

Body: dizziness, headache.

Blood: platelets, leukopenia.

Circulation: Sacrifice heart failure, atrial block - thorough hypotension, fainting.

Central nerve: nightmares, hallucinations, depression, anxiety, mental illness.

Skin: hair loss, skin rash, reaction like psoriasis and worsen psoriasis, hemorrhage.

Eyes: dry eyes, visual disorders.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Stadnolol 50 drugs contraindicated in the following cases:

Metabolic acid infection;

Hypotension;

Severe peripheral disorders;

Severe asthma;

Chronic obstructive pulmonary disease (COPD);

Chrome -preferred cells have not been treated;

Patients with slow sinus rhythms (

Collaborate with Verapamil.

Caution when using

should not stop using beta receptor blockers suddenly.

Special monitoring of treatment carefully in the following cases:

Patients with asthma or a history of airway obstruction.

Patients with diabetes with high blood sugar levels (due to the risk of serious hypoglycemia).

Patients under strict diet for a long time and patients who have exertion activity (due to the risk of serious hypoglycemia).

Patients with chrome cell tumors (adrenal tumors; have been indicated with previous alpha blockers).

Patients with impaired renal function.

Beta receptor blockers should only be used after a careful consideration between benefits/risk in patients with a history or a family history of psoriasis.

Beta receptor blockers can increase sensitivity to allergens and increase the severity of anaphylactic reactions. Therefore, beta receptor blockers should only be used if it is really necessary in patients with a history of severe sensitivity reactions and patients using specific sensitivity reduction therapy (due to the risk of serious reactions).

The use of Atenolol can give positive results in doping tests. It is unknown for the consequences of health when using Atenolol as a stimulant. Do not exclude heavy risks for health.

Stadnolol 50 contains lactose. This medication should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or glucose -galactose.

The ability to drive and operate machinery

Patients using the drug must be monitored regularly. Different reactions in each person can change alertness as the degree of driving ability, operating machinery or working without sure protection. Pay special attention when starting therapy, when increasing the dose or changing drugs or taking alcohol at the same time.

Pregnancy

atenolol through the placenta fence and appear in the blood of the umbilical cord. No studies have been conducted on the use of Atenolol in the first 3 months of pregnancy and cannot exclude the possibility of damage to the fetus. Atenolol has been used under close monitoring in the treatment of hypertension in the last 3 months of pregnancy. Use Atenolol for pregnant women to treat hypertension from mild to medium related to the fetal reduction.

Using Atenolol for women who are or are likely to be pregnant needs to consider the benefits and risks, especially in the first and middle three months of pregnancy, because the beta blockers are associated with reducing placental perfusion that can lead to fetus in the uterus and premature birth.

Breastfeeding period

Atenolol excreted breast milk at a rate of 1.5 - 6.8 times higher than the concentration of drug in the mother's plasma. There have been notifications about the harmful effects of breastfed children when the mother uses Atenolol, such as slow heart rate or hypoglycemia of clinical significance. Premature babies or kidney failure can be susceptible to unwanted effects. Therefore, Atenolol should not be used in nursing mothers.

Medicinal interaction

Hydropherical drugs, diuretics, vasodilators, 3 -ring antidepressants, barbiturate, phenothiazine: increase the lowering effect of Atenolol's blood pressure.

Anti -arrhythmia: Increasing heart inhibition effect of Atenolol.

Verapamil or diltiazem channel blockers or other anti -arrhythmic drugs (disopyramide): hypotension, heartbeat or other perhantic rhythms may occur (should monitor patients carefully).

Nifedipine calcium channel blockers: increases the ability to lower blood pressure and in some separate cases, can progress heart failure.

heart glycosides, reserpine, alpha-methyldopa, guanfacine, clonidine: slow heart rate, delay the transmission of heart impulses. Stop clonidine suddenly used with Atenolol may seriously increase blood pressure. Therefore, when using clonidine with Atenolol should not stop clonidine until not using Atenolol a few days earlier. Then can only reduce clonidine dose slowly.

Oral diabetes treatment, insulin: Atenolol increases hypoglycemic effects. The warning signs of hypoglycemia such as tachycardia and tremor are covered or mitigated. Therefore, regular glycemic examination.

noradrenaline, adrenaline: can cause excessive hypertension.

indomethacin: reduces the hypotension effect of atenolol.

Anesthesia/anesthetics: Increases the impact of hypotension, increases the negative muscle impact (notice to the anesthetic doctor about the use of Atenolol).

Peripheral muscle relaxants (e.g. Succinylcholine Halide, Tubocurarine): Atenolol increases and prolongs muscle relaxation (notification to anesthetist about the use of Atenolol).

Storage

Store in closed packaging, dry place. The temperature does not exceed 30 ° C.

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