Stadsone 16 Stella is used to fight inflammation, inhibit immunosuppressive (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Methylprednisolone

Ingredient

Composition information	Content
Methylprednisolone	16mg

Uses

indications

Stadsone 16mg drug is indicated in the following cases:

Treatment of a number of diseases including causes of hematology, allergies, inflammation, cancer and autoimmune. The drug is often used in the form of esterification or non -esteration to treat diseases that corticosteroids have.

Due to Prednisolone methylation, methylprednisolone has only mineralocorticoid effect (very little salt metabolism), not suitable for treating adrenal insufficiency. If using methylprednisolone in this case, an additional mineralocorticoid.

methylprednisolone has anti -inflammatory, immunosuppressive and anti -cell anti -proliferative effects. The anti -inflammatory effect is caused by methylprednisolone that reduces production, releases and reduces the activity of inflammatory mediators (such as histamine, prostaglandin, leucotriene ...), thus reducing the initial manifestations of the inflammatory process.

Methylprednisolone inhibits leukemia to stick to damaged vessels and immigrated in damaged areas, reducing permeability in that area, so white blood cells are less to the damaged areas. This effect reduces vessel escape, swelling, edema, pain.

The immunosuppressive properties reduce response to slow and instant reactions (type III and Type IV). This is due to inhibition of toxic effects of antigen complex - the body causes allergic vasculitis in the skin.

By inhibiting the effects of lymphokin, target cells and macrophages, corticosteroids have reduced allergic contact dermatitis reactions.In addition, corticosteroids also prevent T lymphocytes and sensitive macrophages from target cells. Anti -cell proliferating effects reduces the characteristics of psoriasis.

Dynamic pharmacokinetics

Absorption: Biochemical is approximately 80%. Maximum effect of 1–2 hours after taking medicine.

Metabolism: methylprednisolone is metabolized in the liver, like metabolism of hydrocortisone.

Elimination: The metabolites are excreted in the urine. Selling time is approximately 3 hours, reduced for obese people.

Before taking Stadsone 16 Stella is used to fight inflammation, inhibit immunosuppressive (3 blisters x 10 tablets)

How to use

oral medication.

Dosage

Dosage for children must be based on the severity of the disease and the patient's response rather than based on the dose prescribed by age, weight or skin surface area. After achieving satisfactory dose, it is necessary to gradually reduce the dose to the only level to maintain the clinical response.

When using Methylprednisolone long -term oral therapy, you must consider using a daily drink. After long -term treatment, methylprednisolone must be stopped.

Adults: Initial dose 2–60 mg/day, depending on the disease, usually divided into 4 times.

Allergic disease (contact dermatitis): Initial recommendations (use 4 mg tablets): 24 mg (6 capsules) of the first day, then gradually decrease 4 mg to 21 tablets daily (for 6 days).

hen:

Children younger than 4 years old (over 3 severe asthma/year) and children 5–11 years old have at least 2 severe illnesses/year: take a dose of 1–2mg/kg/day (maximum 60 mg/day). Can be added to asthma treatment.

Adults and teenagers have at least 2 severe asthma/year: take a dose of 40–60 mg/day, take 1 time or divide into 2 times. Can be added to the maintenance dose of aerobic corticosteroid or bronchodilators of the Beta-2 transportation for prolonged effect.

Can continue to take corticosteroids for short -term (3–10 days) until the patient reaches 80% of the maximum exhalation (PEF) and until the symptoms are out of symptoms. Once asthma has been well controlled, it is necessary to reduce the dose of corticosteroids.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Stadsone 16, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nerve: Insomnia, nervousness is easily agitated.

digestion: Increase appetite, indigestion. Skin: Skin.

Endocrine and metabolism: diabetes.

nervousness and bone: joint pain.

Eyes: cataracts, glaucoma.

Respiratory: Nosebleeds.

Uncommon, 1/1000

Central nerve: dizziness, convulsions, mental disorders, fake tumors in the brain, headache, mood change, delirium, hallucinations, refreshment.

Cardiovascular: edema, hypertension. skin: acne, skin atrophy, bruising, tissue hyperpigmentation.

Endocrine and metabolism: Cushing syndrome, pituitary inhibitor - kidney, slow growth, glucose intolerance, reduced blood potassium, alkaline contamination, amenorrhea, sodium and water, hyperlem of blood glucose.

digestion: stomach ulcers, nausea, vomiting, bloating, esophageal ulcer, pancreatitis.

nervousness and bone: muscle weakness, osteoporosis, fracture.

Other: Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Stadsone 16 contraindications in the following cases:

Too hypersensitivity to any component in the formula.

Severe infections, except for bacterial shock and meningitis.

Viral, mushroom or tuberculosis skin lesions.

using a living virus vaccine.

Caution when used

Use cautiously in patients with osteoporosis, new blood vessels, mental disorders, stomach ulcers, duodenum ulcers, diabetes, hypertension, heart failure and growing children, liver failure, kidney failure, glaucoma, gland disease, cataract.

Due to the risk of unwanted effects, caution must be used with all body corticosteroids for the elderly, with the lowest doses and in the shortest possible time.

Acute adrenal insufficiency may occur when stopping the drug suddenly after a long time of treatment or when stress.

When high doses, can affect the effects of vaccine vaccine.

Stadsone 16 contains lactose excipients. This medication should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or glucose -galactose.

Stadsone 16 contains Sucrose excipients (white sugar). This medication should not be used for patients with rare genetic problems that are fructose intolerance, glucose-galactose malabsorption or enzyme deficiency.

The ability to drive and operate machinery

The effect of corticosteroids on the ability to drive or use machines has not been evaluated. There is no evidence that using methylprednisolone affects the ability to drive and use machines. There may be no harmful effects of corticosteroids on the ability to drive or operate machinery.

Pregnancy

For extension of methylprednisolone for the mother can lead to mitigation of the baby's weight. In general, using methylprednisolone in pregnant people requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child.

Breastfeeding period

The drug should be used to use the drug very carefully.

Drug interaction

methylprednisolone is an enzyme induction cytochrome P450 and is the substrate of isoenzyme CYP3A, so the drug affects the metabolism of cyclosporin, erythromycin, phenobarbital, phenytoin, carbamazepine, ketoconileole, ketoconolate, ketoconolole Rifampicin.

Phenytoin, Phenobarbital, Rifampicin and diuretics decreased potassium can reduce the effectiveness of methylprednisolone.

methylprednisolone may cause hyperlemor of blood glucose, so higher insulin dose is needed.

Cavalry of the drug: Due to no studies on the correspondence of the drug, not mixing this drug with other drugs.

Storage

In closed packaging, dry place. The temperature does not exceed 30 ° C.

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