Stafloxin 200 Stella Treatment of infections (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Ofloxacin

Ingredient

Composition information	Content
Ofloxacin	200mg

Uses

Indications

Stafloxin 200 drugs are indicated in the following cases:

Prostatitis.

Renal failure. Ofloxacin has a strong bactericidal effect. The mechanism of action is not fully known.

Like other antibacterial quinolones, Ofloxacin inhibits DNA-GYRASE of many Gram-negative bacteria and inhibits Topoisomerase IV of many gram-positive bacteria that are essential enzymes in the process of duplication, code and DNA repair of bacteria.

pharmacokinetic

ofloxacin is absorbed quickly and well through the digestive tract. Oral bio -bio -bio -bio -bio -bio -bio -biological concentration has 3-4 micrograms/ml, 1-2 hours after taking 1 dose of 400 mg. Absorption is slowed upon food but the absorption rate is not affected.

Half lifetime in plasma is 5 - 8 hours; In the case of renal failure, sometimes lasts 15 - 60 hours depending on the degree of renal failure, then the dose adjustment is needed. Ofloxacin is widely distributed into body fluids, including cerebrospinal fluid and well penetrated into tissues. About 25% of the plasma concentration in plasma is attached to plasma proteins. Drugs through the placenta and secretion through milk. There is relatively high concentration in bile.

When using single dose, less than 10% ofloxacin is converted into desmethyl-massoxacin and ofloxacin n-oxyd. Desmethyl-Ofloxacin has an average antibacterial effect. However, the kidneys are still the main discharge of Ofloxacin, the drug is filtered through the glomerular and excreted through the renal tubules. 75 - 80% of the drug is excreted in the urine in the form of non -metabolic for 24 to 48 hours, high concentration of drugs in the urine. Less than 5% of the drug is excreted in the form of metabolism in urine; 4 to 8% of the drug excreted in the feces. Only a small amount ofloxacin is discharged by hemolysis.

Before taking Stafloxin 200 Stella Treatment of infections (2 blisters x 10 tablets)

How to use

Stafloxin 200 drugs are taken orally, preferably in the morning.

Dosage

Dosage for treatment in the following cases:

Prostatitis: 300 mg every 12 hours in 6 weeks.

Cervical gonorrhea and uncomplicated cervical and urethra: The only dose of 400 mg.

Cervical inflammation and urethritis are not due to gonorrhea: 400 mg/day single dose or dosage.

Skin infection and soft tissue: 400 mg x 2 times/day.

Lower urinary tract infection: 200 - 400 mg/day.

Infections of urinary tract: 200 - 400 mg/day, if necessary, increase the dose to 400 mg 2 times/day.

Acute bacterial infections of chronic bronchitis: 400 mg/day, if needed to increase the dose to 400 mg x 2 times/day.

Persons of renal function: After the normal starting dose, the dose should be reduced in patients with renal function.

The normal treatment time from 5 to 10 days except for non -complicated gonorrhea infection is recommended for a single dose. Treatment time should not exceed 2 months.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms: The most common is the mental nerve manifestations such as confusion, seizures, muscle seizures, hallucinations and tendon -muscle disorders. The QT interval can be prolonged, digestive disorders (vomiting, oral mucosa) may be encountered in some cases of overdose levofloxacin.

Management: There is no specific antidote, symptomatic treatment. Must monitor nerve manifestations, make electrocardiograms to monitor the QT interval. Kidney function must be monitored to evaluate the ability to eliminate drugs. In the following days, it is necessary to advise patients to avoid capturing the tendon muscles overwork and return to physical activity gradually. Hemolysis, abdominal refinement does not help to eliminate ofloxacin.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Stafloxin 200, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea, abdominal pain.

Neurology: headache, dizziness, fatigue, tremor, drowsiness, insomnia, nightmares and visual disorders. skin: skin rash, itching, skin reaction too hypersensitivity.

Serious reactions are capable of not recovering and causing disabilities, including tendonitis, tendon breakdown, peripheral neuropathy and adverse effects on the central nervous system.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Stafloxin 200 contraindications in the following cases:

Patients with hypersensitivity to other quinolone or any excipients of the drug.

Patients with a history of tendonitis.

Patients with a history of epilepsy or low epilepsy threshold.

Military or adolescents are growing and pregnant or nursing women.

Patient deficiencies or potentially active deficiencies Glucose-6-phosphate dehydrogenase.

Precautions when using

avoid the use of Fluoroquinolone antibiotics for patients who have experienced serious reactions related to fluoroquinolone. Stop using the drug as soon as there are signs or first symptoms of any serious harmful reactions.

Stop immediately treating with ofloxacin if any:

The first sign of hypersensitivity reactions. Rest, limit movement until diagnosis of tendonitis or tendon is excluded.

Be cautious when using ofloxacin for:

Patients with renal failure.

Check the patient condition periodically. If another infection occurs, the appropriate therapy is required.

The ability to drive and operate machines

Pay attention to the body's response to the drug before driving or operating machinery. Some unwanted effects (such as dizziness/dizziness, drowsiness, visual disorders) can reduce the ability to focus and react of the patient.

Pregnancy

Based on a limited amount of data on humans, the use of fluoroquinolon during the first three months of pregnancy is not related to increased risk of large defects or other side effects on pregnancy results. Animal studies have shown that there is an unprocessible cartilage in mature cartilage but does not have a teratogenic effect. Therefore, do not use ofloxacin during pregnancy.

Breastfeeding period

ofloxacin is excreted in breast milk in small amounts. Due to the risk of joint disease and other serious toxicity in breastfeeding, breastfeeding should be stopped during treatment with Ofloxacin.

Medicinal interaction

antacids reduces the absorption ofloxacin.

Anticoagulant: Ofloxacin increases the effects of acenocoumarol and warfarin, which is at risk of bleeding. Must check regularly INR. Sometimes it is necessary to adjust the anticoagulant dose during the treatment period ofloxacin and after the stop ofloxacin.

iron oral iron reduces the absorption ofloxacin.

Sucralfate reduces the absorption ofloxacin.

Storage

Store in a closed container, temperature from 15 - 30 ° C. Avoid light.

Other drugs

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