Star Sore Throat OPV tablet without sugar treatment, sore throat (2 blisters x 12 tablets)

Dosage form Sucker
Specifications Box of 2 blisters x 12 tablets
Ingredient Tyrothricin, lidocaine, cetrimid
Indication Sore throat, laryngitis, sore throat

Ingredient

Thành phần cho 1 viên

Composition information	Content
Tyrothricin	4mg
Lidocaine	1mg
Cetrimid	2mg

Uses

indications

Star Sore Throat is indicated in the following cases:

Treatment of sore throat, sore throat, bacterial infections in the mouth and gums.

Pharmacology

tyrothricin: is a complex mixture of polypeptides from Bacillus Brevis bacteria and the main activity of tyrothricin comes from neutral gramicidin (accounting for 20%), neutralizing phosphorylation of respiratory chain. The drug has the main effect against gram -positive bacteria and bacteria, against some fungi and some Gram -negative bacteria, used in a single or combined with other antibacterial drugs in local infection treatment mainly in the skin and mouth.

Cetrimonium Bromide: is the previous name of Cetrimide. Cetrimide is a quadratic ammonium antiseptic and cation surface activity. The large surfactants in the water are relatively large, creating a cation complex responsible for surfactants and a small amount of non -working anion.

In addition to emulsifying and cleansing properties, quadratic ammonium antiseptic also has the activity against gram -positive bacteria, and at high concentrations, against some Gram -negative bacteria. Pseudomonas spp. As well as Mycobacterium tuberculosis, most of which resist the activity of cetrimide. Cetrimide is not effective against bacterial horoscopes, but has a variety of antifungal activity and effective against some viruses.

Lidocaine: is local anesthetic, amide group, with average time. The mechanism of action is caused by closing both the generation and transmission of nerve impulses by reducing the permeability of the nerve cell membrane with sodium ions, thus stabilizing the membrane and inhibiting the reducing, leading to a decrease in the transmission of the active voltage and then the impulse transmission block. Lidocaine reduces sore throat and pain when swallowing inflammation.

Dynamic pharmacokinetics

tyrothricin: operating on the spot in the mouth and throat, only a small amount expected to be absorbed by the oral tissue.

Cetrimonium bromide: quickly absorbed in the gastrointestinal tract and is eliminated in the form of unchanged in feces and urine.

Lidocaine: absorbing through the gastrointestinal tract, through the circulatory cycle about the liver door and only 35% of the constant dosage is achieved at completely body. Lidocaine is widely distributed in body tissues. The cohesion with plasma proteins varies and depends on the concentration.

At the concentration of 1–4 mcg/ml, about 60–80% of the drug is connected to plasma proteins. Lidocaine is mainly associated with Alpha-1-acid Glycoprotein (Alpha-1-AGP) and the level of cohesion with Alpha-1-AGP depends on plasma protein levels.

Lidocaine through the brain barrier and the placenta. Lidocaine is also distributed into milk. In breast milk, Lidocaine concentration is approximately 40% of serum concentration. Lidocaine has an initial selling time of 7–30 minutes and the last waste sale time is 1.5–2 hours. Lidocaine is metabolized in the liver.

Pharmacological effects or toxicity of similar metabolites but weaker than lidocaine. Excretion in urine is mainly in the form of metabolites (90%) and a small amount (

Before taking Star Sore Throat OPV tablet without sugar treatment, sore throat (2 blisters x 12 tablets)

How to use

Suck the pills slowly in the mouth. Do not chew or swallow.

Dosage

Adults and children over 6 years old:

Mild infections - medium: gradually melt a tablet every 2–3 hours.

Severe acute bacterial infections: gradually dissolve one tablet every 1–2 hours.

Children from 6 to 12 years of age must not take more than 3 tablets/day. Adults and children over 12 years of age do not get more than 8 tablets/day.

Treatment time: Star Sore Throat is only for short -term treatment for 5–7 days. In the case of inflammation or sore throat accompanied by high fever, headache, nausea, or vomiting, no more than 2 days without medical advice.

Elderly: No need to reduce the dose.

Do not exceed the recommended dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? Actively monitor for timely management measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Star Sore Throat, you may experience unwanted effects (ADR).

Common, ADR> 1/100

No report.

Uncommon, 1/1000

No report.

Rare, 1/10000

Difficulty breathing or swallowing.

swelling of the face, lips, tongue or throat.

It tingling in the mouth or throat (uncomfortable in the mouth).

irritation in the mouth if too many drugs for a long time.

Very rare, ADR

Digestive: Nausea when sucking overnight or too much.

Instructions on how to handle ADR

Notice immediately to the doctor or pharmacist the harmful reactions encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

Star Sore Throat is contraindicated in the following cases:

Too hypersensitivity to tyrothricin, cetrimonium bromide, lidocaine or any ingredient of the drug.

Children under 6 years old.

Hypersensitivity to the amide anesthetic anesthetic.

Be cautious when using

According to the FDA, if the large amount of lidocaine into the mouth of the newborn and young children or children accidentally swallowed too much can cause adverse reactions such as seizures, serious brain damage and cardiovascular problems. There have been some cases of overdose due to improper use of the drug or children accidentally swallowed causing serious consequences such as hospitalization or death.

The drug is not used during oral, eating or shortly after because the local anesthetic effect of Lidocaine can temporarily paralyze the mouth and throat, affecting swallowing. Avoid eating and drinking when the loss of sensation remains. Use very carefully for people with liver disease, heart failure, severe deficiency of blood oxygen, severe respiratory failure, reduced blood volume, shock, heart block, not completely or slow heart rate, rhythmic and atrial fibrillation.

Use cautiously in serious or weak patients, because it is prone to body poisoning with Lidocaine. Do not brush your teeth first or immediately after using the capsule. The simultaneous use of surfactants (for example, toothpaste) may reduce the effects of cetrimide.

Notify your doctor or pharmacist before using the drug if you have a sore throat for a few days and fever; Symptoms do not improve or last more than 5–7 days; Sore throat accompanied by high fever, dizziness, vomiting or difficulty swallowing; There is an open wound or damage to the throat mucosa or a wide mouth due to the exposure of the drug to the damaged mucous membranes, increasing the risk of Lidocaine overdose.

This drug contains 1592 mg of sorbitol/tablet. It should be paid attention to the synergistic effect due to simultaneous use with drugs containing sorbitol (or fructose) along with a diet with sorbitol (or fructose). Sorbitol amounts can affect the bioavailability of oral drugs simultaneously.

The drug contains 15 mg of aspartam/tablet. Aspartam is a source of phenylalnine, causing harm if the patient has phenylketone (PKU).

The ability to drive and operate machinery

There is no evidence of the effect of the drug on the ability to drive and operate machinery.

Pregnancy

Lidocaine passes through the placenta but is noted that there is no harmful effect on the fetus. However, there is no clinical data on drug use during pregnancy and data collected in animal experiments are limited. Therefore, only tablets should be used during pregnancy when really necessary.

The period of breastfeeding

Lidocaine is distributed in breast milk in very small amounts, so there is no risk of harmful effects on breastfeeding. However, there is no clinical data on the use of drugs when breastfeeding. Therefore, should only use the drug when really necessary.

Drug interaction

tyrothricin: There is no clinical body interaction that is predicted for tyrothricin because it is not absorbed from the digestive tract.

Cetrimonium bromide: Concomitant use with surfactants (e.g. toothpaste) can reduce the activity of Cetrimonium Bromide (Cetrimide).

lidocaine:

Adrenaline in combination with Lidocaine reduces the absorption and toxicity, thus extending the time of the effect of Lidocaine. Amide type of anesthetic in combination with anti -arrhythmic drugs increases the risk of cardiac inhibition.

Beta blockers: Concomitance with Lidocaine can slow down lidocaine metabolism due to reduced blood flow in the liver, leading to an increased risk of Lidocaine poisoning.

Cimetidine may inhibit lidocaine metabolism in the liver, leading to an increased risk of lidocaine poisoning.

Sucinylcholine: Concentrated with lidocaine may increase the effect of sucinylcholine.

Lidocaine increases the effects of Colchicine, Tamoxifen, Salmeterol, Tolvaptan.

Lidocaine is increased by amiodarone, beta blockers, Conivaptan; Reduced effects by cyproterone, Eravirine, Peg-Interferon Alfa-2B, Tocilizumab.

Storage

Leave the drug at a temperature of less than 30 ° C, in a dry place, avoid light.

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