Statinagi 10 Agimexpharm treats hypercholesterol blood, reduces the risk of myocardial infarction (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Atorvastatin

Ingredient

Composition information	Content
Atorvastatin	10mg

Uses

indications

Statinagi drugs are indicated in the following cases:

Hyper cholesterol: Statinagi is appointed to supplement dining therapy to reduce total cholesterol levels, LDL cholesterol in patients with hypercholesterol blood cholesterol (type IIA and IIB) Triglyceride is low. The heart, reducing the risk of coronary coronary regeneration procedures, reduces the risk of death from cardiovascular disease. Other lipid treatments.

ATC code: C10AA05.

Statinagi contains Atorvastatin is a competitive inhibitor with hydroxymethylglutaryl Coenzym (HMG - COA) Reductase, preventing HMG - CoA into Mevalonate, precursor cholesterol, thus inhibiting cholesterol synthesis, reducing cholesterol in liver cells, stimulating the synthesis of LDL (IIPOLTOIN) And thereby increases LDL transport from blood, resulting in reduced cholesterol levels in plasma. At normal doses, HMG - CoA Reductase is not completely inhibited, so there is still enough meevalonic acid for many metabolic processes. All statins reduce LDL concentration very effectively, in which Atorvastatin reduces the strongest LDL cholesterol (25 - 61%) compared to any drug used alone, and shows prospects for patients who need to reduce cholesterol, which is now only achieved when combined with drugs.

Atorvastatin increases the concentration of HDL cholesterol (high density lipoprotein) from 5-15% and thus lowering LDL/HDL ratios and total/HDL cholesterol.

Atorvastatin also reduces plasma triglycerides at a lower level (10-30%) by increasing the clearance of VLDL (Lipoprotein very low density) residual by LDL receptor.

Response treatment with Atorvastatin can be seen within 1-2 weeks after starting the drug and usually reaches up to 4-6 weeks.

Maintain maintenance during long -term treatment. In clinical studies, evidence suggests that Atorvastatin significantly reduces coronary artery events, all cardiovascular events have existed and reduces the total number of deaths in people with coronary artery disease (with a history of angina or acute myocardial infarction) and people with plasma cholesterol 5.5 mmol/liter or higher. Atorvastatin also plays a role in the primary disease prevention (acute 1) coronary artery disease in patients with hypercholesterol higher risk of coronary artery event.

pharmacokinetics

Atorvastatin is quickly absorbed after drinking and is not affected by food.

Peak concentration in plasma is achieved in 1-2 hours.

Over 98% of Atorvastatin is connected to plasma proteins, then specialized in 70% of the liver into metabolites with or non -active, then eliminated feces. Elimination through the kidneys of Atorvastatin

Before taking Statinagi 10 Agimexpharm treats hypercholesterol blood, reduces the risk of myocardial infarction (6 blisters x 10 tablets)

How to use

Take the only dose at any time of the day, meal or hunger. Because the synthesis of cholesterol in the liver occurs mainly at night, taking the drug in the evening will increase the drug effect.

Patients need to follow a standard diet, low cholesterol, before taking statinagi and must continue to maintain this diet during treatment.

Dosage

Starting dose: 10 mg, once a day. Adjust the dose every 4 weeks, depending on the response.

Maintenance dose of 10 - 40 mg/day. If necessary, the dose can be increased, but not more than 80 mg/day.

Need to monitor the harmful reactions of the drug, especially the harmful reactions to the muscle system.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? If overdose, symptomatic treatment and necessary support measures.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using the drug often has unwanted effects (ADR) such as:

The harmful reactions are divided by frequency: very common (ADR: ≥ 1/10), common (1/100 ≤ ADR Atorvastatin is well tolerated. The side effects are often mild and transient: diarrhea, constipation, flatulence, abdominal pain, nausea; headache, dizziness, blurred vision, insomnia, weakness, muscle pain - joints, temporary liver enzymes and recovery when stopping the drug.Uncommon: muscle disease (combining muscle weakness and increasing: CREATIN PHOSPHOKOXASE Plasma), skin rash; Rhinitis, sinusitis, sore throat, cough.

Rare: Machine, muscle pilot leads to secondary acute renal failure due to myoglobinuria.

The following side effects have also been reported:

Cognitive decline (such as memory loss, confusion ...).

Hyperglycemia.

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Statinagi drug contraindicated in the following cases:

Hypersensitivity to Atorvastatin or any ingredients of the drug.

Be cautious when used

It is necessary to consider when taking drugs in the statin group for patients with risk factors leading to muscle damage. The drug in the statin group is at risk of causing harmful reactions to the muscle system such as muscle atrophy, muscle inflammation, especially for patients with risk factors such as patients over 65 years old, patients with untreated thyroid diseases, patients with kidney disease. Need to closely monitor the harmful reactions during drug use.

Before starting treatment, it is necessary to eliminate the causes of hypercholesterol blood cholesterol such as: under -control diabetes, thyroid disobsius, kidney syndrome, blood protein disorders, biliary liver disease, due to some other drugs, alcohol addiction and total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides.

Must conduct periodic lipid quantification, with a distance of less than 4 weeks, and adjust the dosage according to the patient's response to the drug.

The goal of treatment is to reduce LDL cholesterol. Therefore, it is necessary to use LDL cholesterol levels to start treatment and evaluate treatment. Only when the LDL cholesterol is not tested, will the total cholesterol use to monitor treatment.

Try to control blood cholesterol with appropriate diet, exercise, lose weight in obese patients and treat other basic diseases.

Need to do liver enzyme test before starting statin treatment and in case of clinical indications for testing later.

Consider monitoring Creatin Kinase (CK) in the case:

Before treatment, CK tests should be conducted in the following cases: impaired renal function, hypothyroidism, self -history or family history of genetic muscle diseases, a history of muscle disease due to statin or fibrat before, a history of liver disease and/or drinking alcohol. Elderly patients (> 70 years old) have risk factors for muscle eligibility, the possibility of drug interactions and some special patients. If CK test results> 5 times the upper limit of normal levels, do not start statin treatment. No pregnancy and only in the case of hypercesting blood very high without responding to other drugs.

The effect of the drug on driving and operating machinery

There is no information on the influence of Atorvastatin on driving and operating machinery. However, when driving or operating the machine, it should be noted that dizziness may occur during treatment.

Use drugs for women during pregnancy and lactation

contraindicated use of Atorvastatin for pregnant women and nursing women. Women are likely to get pregnant, so they should use effective contraceptive measures. Do not use Atorvastatin if suspected of pregnancy.

Interactive drug

Interaction of drugs with other drugs and other types of interactions:

Avoid treating atorvastatin combination with cyclosporin, erythromycin, gemfibrozil, iTraconazole, ketoconazole (due to inhibition of cytochrom CYP 3 A4), with niacin at lipid lower doses (> 1 g/day), with colchicin and with other fibrat cholesterol -causing fibrat cholesterol because of the muscle and muscle can cause muscles and muscles Van.

Atorvastatin may increase the effects of warfarin. Prothrombin must be determined before starting to use statin and regular monitoring in the first stage of treatment to ensure no change in prothrombin time.

Atorvastatin and bile acid -mounted resin (cholestyramin, colestipol) have a mechanism of additional effects for each other; Combining these groups of drugs has a plus effect on LDL cholesterol. However, this group of drugs can significantly reduce the bioavailability of Atorvastatin when taken with, so the time to use these two drugs must be about 2 hours apart to avoid clear interactions due to the drug attached to the plastic.

Limit the coordination of Atorvastatin with other lipid medications because of its ability to increase muscle disease.

Although there is no clinical interaction studies in clinical interaction, there is no clinical significant interaction with Atorvastatin with enamel inhibitors, angiotensin, beta blockers, calcium channel blockers, diuretics and nonsteroidal anti -inflammatory drugs.

The simultaneous use of statin lipid medications with HIV and hepatitis C (HVC) can increase the risk of the most serious muscle damage, which is muscle pattern, kidney damage leading to kidney failure and may be fatal. Statin Protease inhibitors with interactions

Telaprevir

Avoid using Atorvastatin lopinavir + ritonavir

used carefully and if necessary
should use the lowest atorvastatin dose.

fosamprenavir

fosamprenavir + ritonavir

saquinavir + ritonavir

nelfinavir

Not more than 20 mg atorvastatin/day

not more than 40 mg atorvastatin/day

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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