Statinrosu 20 meyer drug treatment for hypercholesterolemia (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Rosuvastatin

Ingredient

Composition information	Content
Rosuvastatin	20mg

Uses

indications

Statinrosu drugs are indicated in the following cases:

Treatment of primary blood cholesterol (type IIA including hypercolular hypercholesterolemia heterozygous family) or mixed blood lipid disorders (type IIB). HMG-CoA Reductase, catalyst the conversion process 3-hydroxy-3-methylglutaryl Coenzyme A into Meovalonate, a precursor of cholesterol. The main action position of rosuvastatin is the liver, the target organs reduce cholesterol, increasing the number of LDL receptors on the surface of the cell in the liver, thus increasing the absorption and catabolism of LDL and inhibiting VLDL synthesis in the liver, thus reducing VLDL and LDL components.

Pharmacokinetics

absorption

Rosuvastatin is absorbed completely through the intestinal tract, with bioavailability of about 20%, reaching the peak concentration in plasma about 5 hours after drinking.

Distribution

Linking with plasma proteins is about 90%.

Metabolism

Rosuvastatin is metabolized in the liver, mainly by Cytochrom P450 ISOENZYM CYP2C9.

Elimination

Sell waste time in plasma is about 19 hours. About 90% of the oral dose of rosuvastatin are eliminated in a constant form (including the active ingredient that is absorbed and absorbed) and the rest is excreted into urine. About 5% are excreted into unchanged urine.

Before taking Statinrosu 20 meyer drug treatment for hypercholesterolemia (3 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Patients should follow a low -cholesterol -low -cholesterol diet before using rosuvastatin and continue to maintain this mode during medication.

Adults: Start 5 - 10 mg/time/day.

After about 4 weeks, if necessary, the dose can be increased to 20 mg/day. Increasing the dose to 40 mg should only be used for patients with high risk of cardiovascular disease (especially patients with hypertension in the family) without achieving treatment targets at a dose of 20 mg and these patients need to be monitored regularly.

People with risk factors lead to muscle damage: start at a dose of 5 mg/1 time/day and only increase to 20 mg if necessary after 4 weeks. Need to monitor closely for the case of 40 mg.

Elderly, Asians: 5 mg/1 time/day. Do not use the 40 mg dose for these patients and those who are using fibrat, ciclosporin drugs.

Children should not use.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

There is no specific treatment for overdose. When an overdose, patients should be treated with symptoms and applied support measures when necessary. Liver function should be monitored and creatine kinase concentration. Blood decomposition may not benefit.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Statinrosu you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: headache, dizziness, cognitive impairment.

digestive: Nausea, abdominal pain.

Systemic: weakness, muscle pain.

Rare, ADR

muscle - bone: muscle disease, muscle pilot, joint pain.

nerve: multiple nerve disease. immunity: Hypersensitivity, eagles. liver: liver enzyme.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Statinrosu drugs contraindicated in the following cases:

Patients with hypersensitivity to rosuvastatin or any ingredients of the drug.

Patients with progressive liver disease include prolonged increased serum transaminase for unknown cause and increased serum transaminase more than 3 times the upper limit of normal levels (ULN).

Patients with severe renal impairment (Creatinine clearance

Patients with muscle disease.

Patients who are taking cyclosporin.

Pregnant and lactating women, women may be pregnant without using appropriate contraception.

Be cautious when using

should perform liver enzyme tests before starting statin treatment and in case of clinical indications for testing later.

Consider monitoring Creatin Kinase (CK) in the case:

Before treatment, CK tests should be conducted in the following cases: impaired renal function, hypothyroidism, self -history or family history of genetic muscle disease, a history of muscle disease due to the use of statin or fibrat before, the history of liver disease and/or drinking a lot of alcohol, elderly patients (> 70 years old) have special risks of medication and drug -related patients. In these cases, the benefits/risks should be considered and monitor patients clinically when treated with rosuvastatin. If the results of CK test> 5 times the upper limit of normal levels, do not start treatment with statin.

During statin treatment, patients need to notify when there are muscle manifestations such as muscle pain, stiff muscle, muscle weakness. When there are these manifestations, patients need to test CK to take appropriate interventions.

The ability to drive and operate machinery

drivers or operating machinery should be cautious when using the drug because the drug can cause dizziness, headache.

Pregnancy

Rosuvastatin is contraindicated in pregnant women. Women may be pregnant should use appropriate contraceptive measures. Because cholesterol and other cholesterol biosynthesis are necessary for fetal development, the potential risk due to HMG-CAA Reductase inhibitors will dominate the benefits of Rosuvastatin treatment during pregnancy. Animal studies show that there are evidence of limited toxicity on the reproductive system. If the patient is pregnant while treating with rosuvastatin, the drug should be stopped immediately.

Lactating period

Rosuvastatin is contraindicated in nursing women. In mice, rosuvastatin excreted in milk. There is no corresponding data on milk excretion in humans. Should consider the importance of the drug for the mother and decide to stop breastfeeding or stop the drug.

Drug interaction

Increased risk of muscle lesions when used simultaneously with the following drugs: Gemfibrozil, other fibrat blood cholesterol, high -dose niacin (> 1 g/day), Colchicin.

may increase the risk of muscle damage, the most serious is muscle pattern, kidney damage leading to renal failure and can be fatal when used simultaneously with protease inhibitors to treat HIV and hepatitis C (HCV) such as Atazanavir, Atazanavir + Ritonavir; Lopinavir + Ritonavir: Need to limit the dose of rosuvastatin up to 10 mg once a day.

Anti -acid drugs: Concomitance with aluminum antacids and Magnesi Hydroxyd, which reduces the level of rosuvastatin in plasma. Should take antacids 2 hours after using rosuvastatin.

Cyclosporin increases the peak concentration in plasma and the AUC of rosuvastatin. If used simultaneously, the dose of rosuvastatin should not exceed 5 mg/ day.

warfarin: simultaneous use of Warfarin (25mg) with rosuvastatin (40mg) does not change the concentration of Warfarin in plasma but increases the INR (International Normine Ratio).

contraceptive oral oral contraceptive drugs (containing ethinyl estradiol and norgestrel) with rosuvastatin increases the concentration of ethinyl estradiol and norgestrel in plasma.

erythromycin reduces the concentration of rosuvastatin. Fluconazole, iTraconazole increases rosuvastatin levels. However, these interactions are insignificant clinical.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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