Stemvir Incepta medicine supports HIV-1 infection treatment (3 blisters x 4 tablets)

Dosage form Box of 3 blisters x 4 tablets
Specifications Tenofovir disoprosil fumarat

Ingredient

Composition information	Content
Tenofovir disoprosil fumarat	300mg

Uses

Indications

Stemvir 300 mg is indicated in the following cases:

HIV -infected treatment - 1. Preventive use of priority drugs.

Integrated liver disease, there is evidence of virus multiplication, alanine concentration of aminotransferase (ALT) in persistent serum serum and there is evidence of hypnosis of inflammation and/or cirrhosis .

There is evidence of anti -hepatitis B lamivudine .

Liver disease is lost.

Tenofovir is indicated for chronic hepatitis B treatment in adolescents from 12 to 18 years old:

Integrated liver disease and evidence of immune disease, such as virus multiplication, persistent increase in serum alt and there is evidence of histological of inflammation and/or cirrhosis.

Pharmacy

Pharmacological group: Antiviral antiviral use, nucleoside and nucleotid inhibitors, ATC: J05AF07.

Tenofovir disoproxil fumarat has an acylic nucleosid phosphonate structure similar to adenosine monophosphate. Hydrolyzed drugs into tenofovir and phosphoryl reaction chemical by cell enzymes to convert into Tenofovir Diphosphate form to prevent the activity of HIV -1 reverse copy enzymes and HBV's polymerase enzymes by direct competition for Deoxyribonucleotide substrate in the virus and finish the DNA chain after attaching DNA chain of the virus.

pharmacokinetic

absorption

Tenofovir disoproxil fumarat is soluble in water, with oral bioavailability about 25%. Oral dose 300mg Tenofovir for HIV -1 -infected patients for maximum serum concentration achieved within 1 ± 0.4 hours.

Distribution

Tenofovir's cohesion with plasma and protein for values lower than 0.7 and 7.2%. The distribution voltage in a stable state is 1.3 ± 0.6 l/kg and 1.2 ± 0.4 l/kg after taking a dose of Tenofovir 1.0 mg/kg and 3.0 mg/kg.

Metabolism and excretion

About 70 - 80% Tenofovir is excreted in urine in the form of unchanged after 72 hours. After taking a dose of Tenofovir 300 mg, the sale time is about 12 - 18 hours. After taking 300 mg doses in a row, about 32 ± 10% of the oral dose is excreted into the urine after 24 hours.

Before taking Stemvir Incepta medicine supports HIV-1 infection treatment (3 blisters x 4 tablets)

How to use

Stemvir drugs are used orally, and used as directed by a specialist.

drink when full.

Dosage

Adults:

The usual recommended dose is 300 mg (1 tablet) x 1 time/day.

Chronic hepatitis B treatment:

There is no optimal treatment time. Treatment suspension can be considered as follows:

HBeAg patients are positive, without cirrhosis, so treatment for at least 6-12 months after HBE serum transferring (HBEAG loss, HBV DNA lost with Anti - HBE) or HBS transferred serum or no longer valid. The concentration of ALT and HBV DNA should be monitored regularly after stopping treatment to detect late virus recurrence.

HBeAg patients are negative, without cirrhosis, so treatment should be at least until HBS transferred serum island or no longer valid. With the treatment time lasting for more than 2 years, it is advisable to regularly review to choose the maintenance therapy that is suitable for patients.

HIV treatment: Treatment according to the instructions of the HIV Prevention Program of the Ministry of Health.

Children:

HIV treatment - 1: For adolescents from 12 - 18 years old and weighs 35 kg or more, recommended dose is 300 mg (1 tablet) x 1 time/day.

For children from 2 - 12 years old: Refer to other forms of preparation.

Safety and effectiveness of tenofovir in patients under 2 years of HIV -1 has not been set.

Chronic liver B tablets: For adolescents from 12 - 18 years old and weighs 35 kg or more, recommended dose is 300 mg (1 tablet) x 1 time/day. The optimal treatment time is not clear.

Safety and effectiveness of tenofovir in patients from 2 to 12 years old with chronic hepatitis B or less than 35kg has not been set.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Can use hematopathy to type tenofovir.

What to do when forgetting a dose?

If the patient forgets to take a 12 -hour dose, there is no need to take the forgotten dose but just take the next dose as the usual course.

If the patient has vomiting within 1 hour after taking the medication, one more dose should be used. If the patient has vomiting more than 1 hour after the time of taking the drug, there is no additional dose.

Special subjects

renal failure : The benefits should be only considered far beyond the risk.

Side Effects

When using Stemvir , you may experience unwanted effects (ADR).

Very common, ADR ≥ 1/10

Disorders of metabolic and nutrition: Hypermath of blood phosphate.

Nervous system disorders: dizziness, dizziness.

Disorders of the digestive system: diarrhea, vomiting, nausea.

Skin disorders and subcutaneous tissues: rash.

Common disorders and other side effects: weakness, fatigue, immunodeficiency symptoms.

Common, 1/100 ≤ ADR

Nervous system disorders: headache.

Disorders of the digestive system: abdominal pain, indigestion, flatulence.

Hepatic disorders: increased transaminase, increased liver enzymes.

Uncommon, 1/1000 ≤ ADR

Metabolic and nutrient disorders: Hematuria, hyperglyceride blood.

Gastrointestinal disorders: pancreatitis.

musculoskeletal disorders and connective tissues: decrease in the mineral density of bones, muscle pattern, muscle weakness.

Kidney and urinary disorders: increase creatin.

Rare, 1/10000 ≤ ADR

Metabolic and nutritional disorders: Lactic acidosis, hyperglycemia.

Liver disorders: Severe liver edema due to fatty, severe hepatitis after treatment.

Skin disorders and subcutaneous tissues: Evaluation.

musculoskeletal disorders and connective tissues: osteoporosis (causing bone pain, muscle pattern, muscle weakness). renal and urinary disorders: acute renal failure, impaired renal function, acute renal necrosis, close -range tubular disease (including fanconi syndrome), nephritis (including acute interstitial inflammation), diabetes.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Stemvir 300 mg contraindicated in the following cases:

Hypersensitivity to Tenofovir or any ingredient of the drug.

Be cautious when using

Patients with lactic acid and severe liver edema due to fatty fatty: can lead to death.

Severe hepatitis after treatment.

Tenofovir when using kidney toxic drugs (such as amphotericin B, foscarnet, NSAIDs ...) will cause increased kidney failure symptoms.

The ability to drive and operate machinery

Because the drug can cause unwanted effects of headaches, dizziness, sleeping, so be careful when driving or operating machinery.

Pregnancy

There are no adequate and controlled studies on pregnant women. So only used when really needed during pregnancy.

Breastfeeding period

Drug interaction

should not be used simultaneously:

Do not use simultaneously with other pharmaceuticals containing tenofovir disoproxil fumarat or tenofovir alafenamid. Didanosin significantly, leading to an increased risk of side effects such as pancreatitis, multiple neuritis. Tenofovir and/or simultaneous use.

Tacrolimus can affect kidney function, should closely monitor when used simultaneously with Tenofovir Disoproxil Fumarat.

Storage

Store in a cool dry place, temperatures below 30 ° C, avoid light.

Other drugs

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