Stomex 20mg Pharbaco medicine for gastroesophageal reflux treatment (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Omeprazole

Ingredient

Composition information	Content
Omeprazole	20mg

Uses

indications

Stomex 20 mg drug is indicated in the following cases:

Gastroesophageal reflux, esophagus. How to inhibit specific enzymes H+/K+ - Atpase, a enzyme related to acid pump (proton) on the surface of the cells, reduces and limits acid secretion, including physiological secretion and stimulation acid secretion. Daily daily dose has anti -secreting effect, this effect depends on the dose with reversible.

Pharmacokinetics

absorption

Stomex 20 mg consists of omeprazole particles that are soluble in the intestine (because omeprazole is canceled in the acidic environment), so Omeprazole only starts to be absorbed after the particles are released in the intestine. Rapid absorption and achieve peak concentration in plasma after about 0.5 - 3.5 hours.

Distribution

Mount with plasma protein 95%.

Metabolism

Omeprazole is metabolized with the enzyme system CYLOCHROME P450 (CYP).

Elimination

After taking the only dose of omeprazole, very few forms have not metabolized in the urine. Most dose (about 77%) is excreted in urine in the form of at least 6 metabolites. The two substances are identified as hydroxyomeprazole and carboxylic acid respectively. The rest of the dose is eliminated through feces.

Before taking Stomex 20mg Pharbaco medicine for gastroesophageal reflux treatment (2 blisters x 7 tablets)

How to use

stomex 20 mg is oral medication.

Dosage

duodenum ulcer, stomach ulcer and esophagitis

20 mg once daily at breakfast, used for 2 weeks, if needed can be used for another 2 weeks.

Cases of difficult ulcers

40 mg, once daily for 4 - 8 weeks.

Zollinger syndrome - Ellison

Start 60 mg, once daily and then adjust the dose according to the response. The dose of over 80 mg should be divided into 2 times daily.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Oral dose to 160 mg is still well tolerated.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Stomex 20 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Systemic: headache, drowsiness, dizziness.

digestive: Nausea, vomiting, abdominal pain, constipation, abdominal distention.

Uncommon, 1/1000

Neurological: insomnia, sensory disorders, dizziness, fatigue.

Skin: urticaria, itching, rash.

liver: temporarily increased transaminase.

Rare, ADR

Hematology: leukopenia, thrombocytopenia, reducing blood, peripheral, exterior, granulocytes.

nerve: Confusion has recovery, agitation, depression, hallucinations in elderly patients and especially in serious patients.

Endocrine: Big breasts in men.

digestive: gastritis, candidiasis infection, dry mouth. liver: jaundice or no jaundice, cerebral disease in people with liver failure. Respiratory: Bronchospasm.

muscle - bone: joint pain, muscle pain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Stomex 20 mg contraindicated drug in the following cases:

Pregnant and lactating women.

Patients with hypersensitivity to any ingredients of the drug.

Caution when using

responding to symptoms when treating with omeprazole does not prevent the presence of gastric malignant tumors.

Thickness is sometimes recorded in the gastric biopsy from patients with long -term treatment with omeprazole.

The ability to drive and operate machinery

stomex does not affect the ability to drive and operate machinery.

Pregnancy

Contraindications for pregnant women.

Lactation period

Contraindications for breastfeeding women.

Interactive drug

drugs that bioavail depends on the stomach pH

Due to the effect of inhibiting gastric acid secretion, omeprazple may affect the absorption of the drug depending on the stomach pH such as ketoconazole, iron, ampicillin.

Metabolic drugs by Cytocrome P450

Omeprazole can extend the excretion time of Diazepam, Warfarin and Phenytoin, which are metabolized by oxidation in the liver.

Although

although interactive with theophyllline or propranolol has not been found and normal objects, there have been clinical reports on interaction with metabolic drugs by the P450 system (such as: cyclosporine, disulfiram, benzodiazepines). Patients should be controlled so if it is necessary to adjust this dose when taken in combination with Stomeex.

Indications for combinations of omeprazole and viriconazole (drugs combined inhibit both CYP2C19 and CYP3A4) for more efficient use when using Omeprazole separately. Normally, there is no need to adjust the dose of omeprazole.

antivirus

Omeprazole has been reported to interact with some antiviral drugs. Clinical importance and mechanism behind these interactions are not known.

Antibiotics

Omeprazole 40 mg has been used in combination with Clatithrotnycin 500 mg every 8 hours for healthy men. Omeprazole plasma concentration increases when combined with clarithromycin.

Storage

Store less than 30 oC, avoid light.

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