Stradein 6mg Usarich Pharm treat worms (4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications Ivermectin

Ingredient

Composition information	Content
Ivermectin	6mg

Uses

indications

Stritin drugs are indicated for treatment of worms only onchocera, although the drug is effective in the treatment of worms, including eelworms in the intestine due to Strongyloides Stercoralis. The role of Ivermectin in worms only in the lymphatic system has not been carefully studied.

Pharmacokinus

iVOMECTIN is the semi -synthetic substance of some Avermectin, a group of substances with large lacton structure, isolated from the fermentation of Streptomyces Avermitilis. Ivermectin has a broad activity spectrum on round worms such as e -worms, hair worms, roundworms, hookworms and Wucheria Bancrofi. However, the drug does not work on liver fluke and tapeworms.

Currently, Ivermectin is a drug that is chosen to treat worms only onchocera Volvulus and is a worm larvae that is only very strong, but has little effect on mature parasites. After drinking 2-3 days, the worm larvae only go away quickly. The corneal larvae and eye rooms are slower.

The effect of the drug may last up to 12 months. One month after use, the larvae at the uterus only mature unable to escape, and then degenerated and eliminated. The effect of prolonged larvae is very helpful in preventing the spread of the disease.

already know quite well the action mechanism of Ivermectin on worms only onchocera. The drug causes direct toxic effects, immobile and eliminating larvae through lymphatic lymphatic. Ivermectin stimulates the secretion of neurotransmitters is Gama acid - Amino Butyric (GABA). In sensitive worms, the drug affects by enhancing the release of gaba after the synap of the nerve joints that cause the worm to be paralyzed.

Ivermectin does not easily join the central nervous system of mammals. Therefore, it does not affect the neurotransmitter dependent of these species.

Dynamic pharmacokinetics

unknown the absolute biological use of the drug after taken. In general, there is no difference between tablets and capsules (46 compared to 50 µg/l).

However, when using ivectin in a alcoholic solution, the peak concentration doubled and the relative bioavailability of the tablet is only 60% of the bioavailability of the solution. The time reaches the peak concentration in plasma for about 4 hours and is not different between the forms of preparation.

Distribution

Ivermectin has an apparent distribution of about 48 l and very low clearance (about 1.2 l/ hour). About 93% of the drug associated with plasma protein.

Metabolism

Not carefully studied. However, the drug was decomposed and methyl in the liver.

Elimination

Half life eliminates after taking the solution for about 28 hours. Ivermectin is excreted through bile and eliminates almost only through stool. Under 1% of the dose is excreted in the urine.

Before taking Stradein 6mg Usarich Pharm treat worms (4 tablets)

How to use

Ivermectin drink with water in the early morning when not eaten or maybe another time, but avoid eating within 2 hours before and after taking the drug.

Not yet determined the safety of children under 5 years old.

Dosage

Adults and children over 5 years old

Use a single dose of 0.15 mg/kg. Higher dose will increase the harmful reaction without increasing the effectiveness of treatment. It is necessary to re -treat the same dose every year to make sure to control the worm larvae only onchocerca. If the patient is seriously infected with the larvae in the eyes, it may be more frequent treatment, such as every 6 months to re -treat 1 time.

Ivermectin dose tutorial to treat onchocerca infection:

weight (kg)

Single dose

15-25

26-44

45-64

65-84

≥ 85?

3 mg

6mg

9 mg

12 mg

0.15 mg/kg

Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Other undesirable effects include seizures, loss of air conditioning, shortness of breath, abdominal pain, abdominal pain and urticaria.

When infected, infusion and electrolytes, respiratory aids, use hypertension if hypotension. Causing vomiting or gastric wash as soon as possible. Then use bleach and other anti -toxic measures if needed to prevent additional absorption into the body.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using strita, you may experience unwanted effects (ADR). Ivermectin is a safe drug, very suitable for broad treatment programs. Most of the unwanted effects of the drug are due to immune reactions to dead larvae. Therefore, the severity of this effect is related to the density of larvae in the skin.

Unwanted effects include: fever, itching, dizziness, dizziness, edema, skin rash, sensitive, pain in the lymph nodes, sweating, shudder, muscle pain, swelling of joints, face swelling (Mazidi reaction). Hypoglycemic hypotension has been notified with sweat, tachycardia, confusion.

usually occurs in the first 3 days after treatment and depending on the dose.

Common, ADR> 1/100

Osteoarthritis: joint pain/epidemic inflammation.

Lymph nodes: enlarged and lymph nodes in the armpits, neck, groin. Skin: itching, skin reactions such as edema, nodules, pustules, skin rash, urticaria. body: Fever. edema: face, periphery. Cardiovascular: Hypotenary blood pressure, tachycardia.

Uncommon, 1/1000

Central nerve: headache.

peripheral nerve: muscle pain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

streamtin contraindicated drugs in the following cases:

Patients with hypersensitivity to any ingredients of the drug.

Patients with diseases with brain fence disorders, such as African trypanosoma and meningitis.

Caution when using

does not have much experience using drugs for children under 5 years old, so it is not for this age.

Due to gaba increased drugs, there is a notion that the drug has the effect on the central nervous system in humans, the barrier of the brain damage (as in meningitis, trypanosoma disease).

When treated with Ivermectin for people with worm -caused dermatitis onchocerca, the reaction can be increased, more harmful reactions may occur, especially edema and make the condition worse.

The ability to drive and operate machinery

There is no data showing that the drug affects the ability to drive and operate machinery. However, the unwanted effect of the drug is headache, dizziness, hypotension that may occur. Therefore, need to be cautious when driving and operating machinery.

Pregnancy

Documents on humans are limited. A study was conducted on a large scale at 14,000 patients taking the drug once a year, in 3 years, 203 babies were born from mothers who used drugs during pregnancy.

The results show that the disabilities from children born from mothers use drugs are not different from the children of mothers who do not take medicine. Because worm larvae are only onchocercca, it is easy to cause blindness, and have not seen a report on the likelihood of teratogenicity, although the drug has been used on a very wide range, it is possible to use Ivermectin after 3 months of pregnancy.

The period of breastfeeding

Ivermectin secretes breast milk with low concentrations (less than 2% of the drug used). Safety for infants has not been determined, so only this medication is used for the mother when the benefits are greater than the risk.

Drug interaction

There has been no notice of harmful drug interactions. However, theoretically, the drug may increase the effects of GABA receptors (such as benzodiazepine and sodium valproat).

Storage

Store in a dry place, avoid light, temperature not exceeding 300C.

Other drugs

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