Strepsils Maxpro Reckitt Benkiser tablets reduce pain in sore throat (12 packs x 8 tablets)

Dosage form Box of 12 packs x 8 tablets
Specifications Flurbiprofen

Ingredient

Composition information	Content
Flurbiprofen	8.75mg

Uses

indications

Strepsils Maxpro package is indicated in the following cases:

Pain relief in severe sore throat. Prostaglandin.

Pain relief, sore throat reduction and sore throat are observed 30 minutes after taking a lozeng and the effect time lasts 2-3 hours.

Dynamic pharmacokinetics

absorption: Flurbiproofen is quickly absorbed after using a lozeng tablet with peak in plasma achieved after 30-40 minutes. The peak concentration is faster, but has the same level as the peak concentration after an equivalent oral dose.

Distribution: Flurbiproofen is rapidly distributed throughout the body, Flurbiproofen is strongly connected to plasma proteins.

Chemical and elimination: mainly metabolized by hydroxylation and excretion through the kidneys. There is a sale time from 3-6 hours. Flurbiprofen is excreted in very small amounts of breast milk (below 0.005 mg/ml).

Before taking Strepsils Maxpro Reckitt Benkiser tablets reduce pain in sore throat (12 packs x 8 tablets)

How to use

Strepsils suck to melt slowly in the mouth.

Dosage

Adults, elderly people and children over 12 years old: 1 tablet to melt slowly in the mouth every 3-6 hours when needed. Maximum of 5 tablets for 24 hours.

Should take the lowest dose effectively in the shortest time needed to reduce symptoms. Patients should consult a doctor if the symptoms are prolonged or worse, or if needed for more than 3 days.

recommend this medication for a maximum of 3 days.

Like all the lozenges, to avoid local irritation, should move the pills around the mouth when you are sucking

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Most patients who have taken a number of important nonsteroidal anti -inflammatory drugs (NSAID) clinically will arise not too nausea, vomiting, epigastric pain or more rare diarrhea.

Tinnitus, headache and stomach bleeding can also occur.

In case of more serious poisoning, it has observed toxicity in the central nervous system with a drowsiness, sometimes stimulating and disoriented or coma.

Sometimes patients appear convulsions.

In serious poisoning, metabolic acidosis can occur and the time of prothrombin/international standardized ratio (INR) may be prolonged, perhaps due to the intervention of the effects of blood clotting factors.

Acute renal failure and liver damage may occur.

There may be asthma attacks in asthma patients.

Management:

The treatment is symptomatic treatment and supportive treatment, including maintenance of airy airway and monitoring purple signs and living signs until stability.

Consider drinking activated carbon if the patient shows an overdose within 1 hour after taking an amount of drugs that can be toxic. If there is regular or prolonged jerky, need treatment with diazepam or lorazepam intravenously.

Use bronchodilators to treat asthma.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using the drug, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: abdominal pain, nausea, indigestion.

rarely, 1/1000

The immune system: Hypersensitivity reaction to urticaria and itching.

Dermatology: Different skin rash.

Nervous system: headache.

rare, ADR

Digestive system: diarrhea, flatulence, constipation and vomiting.

Very rare, ADR

The immune system: Hypersensitivity reaction. Symptoms may be swelling of the face, tongue and larynx, shortness of breath, tachycardia, hypotension (anaphylaxis, angioed or severe shock). Hen and bronchospasm.

Digestive system: Peptic ulcer, perforation or stomach bleeding, black stool, vomiting blood, sometimes fatal, especially in the elderly. Mouth ulcers, gastritis. Execute phase of colitis and Crohn's disease.

Nervous system: Aseptic meningitis.

Kidney: Acute renal failure, kidney necrosis, especially when used in the long term, comes with hyper Urea and edema.

Liver: liver disorders.

Hematology: Disorders of hematopoietic disorders (anemia, leukopenia, thrombocytopenia, hypoglycemia, grain leukemia). The first signs are fever, sore throat, hot mouth ulcers, symptoms like influenza, serious exhaustion, hemorrhage and bruise.

Skin: Severe skin reactions such as bullous reactions include Stevens-Johnson syndrome, diverse erythema and poisoned epidermal necrosis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

contraindicated drugs in the following cases:

Hypersensitivity to Furbiproofen or any excipients of the drug.

Patients who have manifested previous hypersensitivity reactions (such as asthma, rhinitis, vascular coverage, or urticaria) reacts with aspirin or other nonsteroidal anti -inflammatory drugs (NSAIDs).

Active gastrointestinal ulcers/hemorrhage or a history of ulcer/recurrent stomach bleeding (two or more stages of ulcer or obvious bleeding have been proven).

History of hemorrhage or perforation of stomach-related steroids with anti-inflammatory drugs before.

Severe heart failure, severe kidney failure or severe liver failure.

The last three months of pregnancy.

Be cautious when used

Unwanted effects can be minimized by using the lowest dose effectively in the shortest possible time to control symptoms (see stomach risk and cardiovascular risk below).

Elderly people have an increase in the frequency of side effects on nonsteroidal anti-inflammatory drugs (NSAID), especially bleeding and gastric perforation, which can be fatal.

Bronchospasm can be promoted in patients who are or have a history of bronchial asthma or allergic disease.

Should avoid simultaneous use of the Package Strepsils Maxpro with nonsteroidal anti-inflammatory drugs including Cycloxygenase-2 inhibitors.

Systemic lupus and mixed tissue luscular disease increase the risk of aseptic meningitis.

Renal failure because kidney function may be worse.

Liver dysfunction.

Be cautious (discuss with a doctor or pharmacist) before starting treatment in patients with a history of hypertension and/or heart failure because there is a report of fluid fluid, hypertension and edema associated with the treatment of nonsteroidal anti -inflammatory drugs (NSAID).

Clinical and epidemiological testing data shows the use of NSAIDs, especially at high doses (2400mg/day) and long -term treatment may be associated with a slight increase in the risk of arterial thrombosis (eg myocardial infarction or stroke).

Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, use systemic sugar, may increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients should be warned of symptoms of cardiovascular events and need to visit a doctor as soon as these symptoms appear.

To minimize the risk of adverse events, the drug is required at the lowest daily doses in the shortest possible time.

There are some evidence that the synthetic inhibitors of cyclooxygenase/prostaglandin may cause decreased fertility in women by affecting ovulation. This can recover when stopping treatment.

Be careful when taking nonsteroidal anti-inflammatory drugs (NSAID) for patients with a history of thick skin disease (ulcerative colitis, Crohn's disease) because these conditions may be worse.

Bleeding, ulcers or perforation of stomach, can be fatal, have been reported to all NSAIDs at any time during treatment, with or without warning symptoms or previous history of stomach events.

The risk of bleeding, ulcers or perforation of the stomach is higher with the increase in the dose of NSAID in patients with a history of ulcer, especially if there is hemorrhage or perforation complications and in the elderly. These patients should start treatment with the lowest dose existing.

Patients with a history of stomach poisoning, especially the elderly, should report any abdominal symptoms (especially stomach bleeding), especially in the early stages of treatment.

Be cautious in patients who use simultaneously with drugs that may increase the risk of ulcerative or hemorrhage such as oral corticosteroids, anticoagulants such as warfarin, selective Serotonin reabsorption inhibitors or platelet -like anti -platelets such as aspirin. When bleeding or stomach ulcers occur in patients using Flurbiproofen, treatment must be stopped.

Serious skin reactions, some deaths, including flaking dermatitis, Steven Johnson syndrome and poisoned diagnosis have been reported rare with the use of nonsteroidal anti -inflammatory drugs (NSAID). Patients seem to have the highest risk of these reactions early during treatment, the onset of reactions occurs in most cases in the first month of treatment. The strepsils maxpro must be stopped when the first manifestation of the skin rash, the mucosal damage or any other signs of the hypersensitivity reaction.

The ability to drive and operate machinery

has no effects expected in the recommended dose and treatment time.

During pregnancy

Can Strepsils MaxPro tablets be used for pregnant women?

While not having a teratogenic effect has been shown in animal experiments, it is advisable to avoid using Strepsils Maxpro lozenges in the first 6 months of pregnancy, if possible in the last three months of pregnancy, contraindicated use of Flurbiprofen because of the risk of early fetal artery tubular closing of the fetus and maybe prolonged pulmonary hypertension.

The onset of skin may be delayed and the time increases with the trend of bleeding in both mother and child.

Breastfeeding period

Package strepsils maxes are used for women who are breastfeeding?

Furbiprofen appears in breast milk at very low concentrations and is not likely to adversely affect infant breastfeeding.

Drug interaction

should avoid combining flurbiprofen with:

Aspirin: Unless low -dose aspirin (not higher than 75 mg/day) is recommended by the doctor, because this may increase the risk of side effects

Other nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen and selective inhibitors Cycloxygenase-2: Avoid simultaneous use of two or more NSAID drugs as this may increase the risk of side effects.

Be careful when using Flurbiprofen in combination with:

Anticoagulants: NSAID anti -inflammatory drugs (NSAID) can increase the effects of anticoagulants like Warfarin.

Hydropower and diuretics because NSAIDs can reduce the effects of these drugs. Diuretics may increase the risk of toxicity of NSAID's kidneys.

corticosteroid: Increased risk of ulcerative or stomach bleeding.

Anti-platelet aggregation drugs and selective Serotonin reabsorption inhibitors (SSRI): Increased risk of stomach bleeding.

cardiac glycosides: NSAID anti -inflammatory drugs (NSAIDs) can worsen heart failure, reduce the filtration rate of glomerular (GFR) and increase plasma glycosides.

Lithium: There is evidence of the ability to increase lithium concentration in plasma.

Methotrexate: There is evidence of the ability to increase methotrexate levels in plasma.

ciclosporin: Increasing the risk of toxicity to the kidneys.

Mifepriston: Do not use nonsteroidal anti-inflammatory drugs (NSAID) in 8-12 days after using Mifepristone because NSAID can reduce the effectiveness of Mifepristone.

tacrolimus: may increase the risk of toxicity to the kidneys when NSAID is used with tacrolimus.

Zidovudin: Increased risk of hematology when NSAID is used with zidovudin. There is evidence of an increase in the risk of joint hematoma and hematoma in people with infected bleeding with viral immunodesic viruses (HM) positive to be treated simultaneously with zidovudine and ibuprofen.

Antibiotics Quinolone: Animal data shows that NSAID may increase the risk of convulsions associated with Quinolon antibiotics. Patients using NSAID and Quinolones may increase the risk of seizures.

Storage

Store at a temperature not exceeding 30 ° C.

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