Sucramed sucralfat 1000mg reliv oral medication for stomach and duodenal ulcer treatment (30 packs)

Sucralfate has 3 characteristics:

In the gastrointestinal tract, sucralfate turns into a sticky, polarized mucus, capable of attaching itself to the damage of the esophagus, stomach, duodenum and colon mucosa. The affinity for these damaged tissues is explained by the electrostatic interaction between sucralfate with negative charges and proteins of inflammatory secretions due to positive charge. Thereby, forming complexes that are isolated and protected the lesions, especially, in the digestive tract where it resists the opposite diffusion of H+ions.

Pepsin resistance and bile salts

Sucralfate molecules are adsorbing pepsin and bile salts that allow the drug to fight against the invasion of these substances on ulcerative mucous membranes.

Stimulates the physical protection factors of the gastric mucosa - Sucralfate duodenum stimulating the production of endogenous prostaglandin, mucus and bicarbonate in the gastric - duodenum mucosa.

In addition, sucralfate inhibits lesions caused by alcohol in animals and human lesions caused by nonsteroidal anti -inflammatory drugs (especially acetylsalicylic acid) on the gastric - duodenum mucosa.

In children

In documentation, clinical data on the use of sucralfate in children is mainly for preventive treatment for ulcers related to stress, esophageal reflux and mucositis are limited. The dose in these studies is from 0.5 g - 1 g, 4 times a day, depending on the age of the child and the severity of the disease and is used without a big problem in tolerance. Due to limited data, it is currently not recommended to use this drug for children under 14 years old.

pharmacokinetics

After drinking, sucralfate passes through the digestive tract and is excreted mainly in stool.

In humans, the absorption in the gastrointestinal mucosa is very small (1-2%); A small amount in a constant form is found in the kidneys, bladder, spleen and in muscle. These parts are excreted mainly through the urinary tract for 3 days.

Aluminum ions can be released from molecules and absorbed by the gastrointestinal mucosa. However, the percentage of aluminum controlled in humans is always within normal limits even after prolonged treatment.

Take 1 pack, 4 times a day for 4 to 6 weeks, ie:

Take 1 pack, 2 times daily, ie:

Take 2 packs in the evening from 2 - 1 hour before dinner or before going to bed about 2 hours after dinner.

No need for use in combination with anti -secretions, antacids or ribbons.

Children:

Safety and effectiveness have not been studied in children under 14 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose?

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Cases of stomach foreign objects (babyzoard) have been reported mainly in patients hospitalized in special care units.

Most of these patients (including infants are not recommended to use sucralfate), which have potential diseases that make it easy to form stomach foreign objects (such as delayed stomach empty due to surgery, drug use, or due to diseases that reduce peristalsis), or are being raised at the same time by catheter.

Children:

Due to not enough data on safety and efficiency, it is not recommended to use sucralfate for children under 14 years old.

Avoid prolonged sucralfate (several months treatment) in patients with chronic renal impairment due to aluminum released in the stomach, although absorbed a little through the gastrointestinal tract, can accumulate in tissues and especially in the brain (risk of cerebral disease).

Although there is no contraindication, sucralfate should not be used for prolonged treatment for blood phosphate subjects (such as primary hyperthyroid glands, rickets due to dysplasia, vitamin resistance).

In the case of stomach ulcers, it is necessary to check the benign ulcer before treatment.

mannitol

This drug contains Mannitol excipients, which should not be used for patients with rare genetic problems about fructose intolerance.

aspartame

The drug contains Aspartame.aspartame is a source of phenylalanin and may be dangerous for people with phenylcetone.

The effect of the drug on the ability to drive and operate machinery

There is no research document on the effect of drugs on drivers or operating machinery.

Use drugs for women during pregnancy and lactation

Pregnant women

Animal studies have not seen any teratogenic effects. In the absence of teratogenic effect in animals, it is not possible to cause deformities in mankind. Indeed, so far, deformity substances for humans have been shown to cause teratogenicity in animals in the research process that has been conducted well in two species.

In clinical practice, there is currently no relevant data to evaluate the ability to cause deformities or toxicity on the fetus of sucralfate used during pregnancy.

Therefore, to prevent, it is best not to use sucralfate during pregnancy.

Take into account the presence of aluminum ions that can affect the transfer: Aluminum salts are the source of constipation that can add to the classic cause of pregnancy; At high doses, the drug can also cause phosphorus deficiency (except for aluminum phosphate). The absorption of aluminum ions is considered minimal and is not at risk of overloading the body if the dose is limited to the day and according to the prescribed time, but this risk is real if preventive measures are not complied with, while the case of a mother suffering from kidney failure: There is a risk of aluminum poisoning in fetus and infants.

Try to limit daily dose and time to use these drugs if possible.

breastfeeding women

It is not recommended to use sucralfate during breastfeeding.

Drug interaction

According to the current understanding, the presence of sucralfate does not change the absorption of quinidine, propranolol, aminophylline and cimetidine.

Sucralfate may slow down and/ or reduce the gastrointestinal absorption of some drugs when used in combination.

To avoid this, it is necessary to take sucralfate for a 2 -hour period with the following drugs:

In case there is no accurate information for other drugs when used in combination with sucralfate, it is advisable to comply with this similar principle.