Sulcilat 750mg Atabay medicine for infections (1 blister x 10 tablets)
Dosage form Box of 1 blister x 10 tablets
Specifications Sultamicillin
Ingredient
| Composition information | Content |
| Sultamicillin | 750mg |
Uses
Indications
Sulcilate Tablet 750mg is indicated for bacterial infections caused by sensitive microorganisms. Typical indications for the following infections:
Lower respiratory infections include bacterial pneumonia and bronchitis.
urinary tract infection and pyelonephritis. Skin infections, soft tissue and gonorrhea infections. Sultamicillin can also be indicated for patients to be treated with sultamicillin/ampicillin after initial treatment with sultamicillin/ampicillin intramuscular/intravenously. biochemical studies for non-cell bacterial systems that have shown sulbactam is the inhibitor of non-restoring beta-lactamase enzymes most important in penicillin-resistant strains. Pharmacokic
Because Sulbactam also binds to some penicillin binding proteins (PBP), for some sensitive bacteria strains, using a combination of sulbactam-ampicillin will be more effective than using only one beta-lactam.
The bactericidal ingredient of ampicillin, as well as benzyl penicillin, prevents sensitive bacteria in the strong cell division by inhibiting mucopeptide biosynthesis in cell walls.
Sultamicillin has an effective antibacterial effect with many Gram (+) and Gram (-) bacteria, including Staphylococcus aureus and Staphylococcus Epidermidis (both penicillin-resistant strains and some methicillin antacids); Streptococcus Pneumoniae, Streptococcus Faecalis and other strains of Streptococcus strains; Haemophilus Influenzae and Haemophilus Parciinfluenzae (both seminarians beta-lactamase and non-birth beta-lactamase); Moraxella Catnrhalis, anaerobic bacteria, including Bacteroides Fragilis and bacteria with them, Escherichia Coli, Klebsiella, Proteus (including two types of Indole+ and Indole-); Enterobacter; Morganella Morganii; Citrobacter; Neisseria meningitidis and neisseria gonorrhoeae.
pharmacokinetics
In humans, after oral use, sultamicillin is hydrolyzed while absorbed to form sulbactam and ampicillin at a ratio of 1: 1 in the circulatory system.
The bioavailability of an oral dose is 80% of sulbactam and ampicillin doses equivalent to intravenous injection. Using the drug after eating does not affect the bioavailability of sultamicillin. The highest concentration of ampicillin in serum after using sultamicillin is approximately twice the concentration of ampicillin when taken orally.
Sell waste time in healthy volunteers using sultactam and ampicillin is 0.75 hours and 1 hour, with 50 - 75% of each substance intact excreted through urine. The selling time increases in the elderly and patients with renal function.
Probenecid reduces the excretion of both ampicillin and sulbactam in the renal tubules. Simultaneous use of probenecid and sultamicillin increases and prolongs the concentration of ampicillin and sulbactam in the blood.
Before taking Sulcilat 750mg Atabay medicine for infections (1 blister x 10 tablets)
How to use
Sulcilat Tablet 750mg medicine Used orally.
Dosage
Sultamicillin dose is recommended in adults (including elderly patients) of 375 - 750mg x 2 times/day.
In both adults and children treated, they are usually continued until 48 hours after fever and other abnormal signs disappear. Typically, it is necessary to treat for 5-14 days but the treatment time may be longer if necessary.
In the treatment of unprocessed gonorrhea, sultamicillin can be used for a dose of 2.25 g (6 tablets 375mg or 3 tablets 750mg). Simultaneous use with 1g propenecid to maintain sulbactam and ampicillin levels in plasma.
Cases of gonorrhea with suspected syphilis should check with black background microscopes before taking sultamicillin and serum tests for at least 4 months.
Recommendations for at least 10 days for any bacterial infections are caused by hemoly streptococci (hemolytic streptococci) to prevent rheumatitis or glomerulonephritis.
Children and children
In patients with severe renal impairment (creatinine clearance ≤ 30 ml/min), the dynamics of sulbactam and ampicillin elimination are also equally affected and therefore the concentration rate of two drugs in plasma is unchanged. Sultamicillin use should be reduced in these patients, just like when using ampicillin and as recommended as follows:
Sulcilate tablet tablet usual tutorials for patients with kidney failure
Creatinine clearance (ml/min/1.73 m2) Slashing time Sultamicllin Tosilat (hourly) Sulcilat tablet dose 750mg recommendations
30 1 1.5 g every 6 - 8 hours
15 - 29 5 1.5 g every 12 hours
5 - 14 - 14 9 1.5 g every 24 hours
CrCl = [(140 - age) x Weight for male patients (kg)]/(72 x The content of creatinine in serum)
For female patients: Value over x 0.85.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when overdose?
Overdose of drugs that causes the main manifestations is the extended reaction of the effects that do not want to be reported, it is necessary to consider the high level of beta-lactam antibiotic concentration in cerebrospinal fluid (CSF) that can cause nervous effects, including epilepsy. Because both ampicillin and sulbactam are removed from the circulatory system by hemorrhage, these procedures can increase the elimination of the drug from the body if used overdose in patients with renal insufficiency.
How to overdose: There is no data on overdose, no overdose of the drug.
What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using Sulcilat Tablet 750mg , you may experience unwanted effects (ADR).
Very common, ADR> 1/10
Common, 1/100 Uncommon, 1/1000 Rare, ADR Not determined frequency The immune system: Anaphylaxis reactions include anaphylactic shock. Systemic: Mucinitis, discomfort. Instructions on how to handle ADR: notify the doctor the unwanted effects when using the drug.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Sulcilat Tablet 750mg is contraindicated in case of a history of hypersensitivity to any penicillin antibiotic.
Caution when using
Serious hypersensitivity reactions (anaphylactic reactions), sometimes deadly, reported in patients being treated with penicillin including sultamicillin.
These reactions often occur in people with a history of hypersensitivity to penicillin and/or hypersensitivity to many allergens. There have been reports on people with a history of hypersensitivity to penicillin with serious reaction when treated with cephalosporin.
Before penicillin treatment, it is necessary to ask the previous allergic history with penicillin, cephalosporin, and other allergens. If allergic reactions occur, the medication should be stopped and applied appropriate treatment.
If you have a serious anaphylactic reaction, you need to be emergency immediately with Adrenalin. It is possible for patients to breathe oxygen, intravenous intravenous and airway ventilation, including internal intubation as directed.
Serious multi -reaction, such as poisoned necrotic (Toxic Epidermal Necrolysis (Ten), Stevens -Johnson syndrome (Stevens -Johnson Syndrome - SJS), scales and diverse roses have been reported in ampicillin/sulbactam treatment patients. If the skin reaction is serious, it is necessary to stop taking this medication and start using appropriate therapy (see the side effects).
Like other antibiotics, it is necessary to continuously monitor the signs of superinfection of non -sensitive bacterial proliferation, including fungi. If there are signs of superinfection, immediately stop taking the drug and/or apply appropriate treatment.
diarrhea caused by Clostridium Difficile (CDAD) has been reported when used for most antibiotics, including sultamicillin, and the severity of mild diarrhea to death. Treatment with antibacterial agents changes the natural microbiological system of the intestine, resulting in excessive development of C. Difficile.
c. Difficile produces toxins A and B, contributing to the development of CDAD. C. Difficile strains produce many toxins that increase the incidence of disease and death, because these infections may be difficult to treat with antibiotic therapies and may need to remove the colon. CDAD should be thought in all patients who appear diarrhea after antibiotics. The medical record should be carefully recorded for a CDAD report that occurs more than 2 months after antibiotic treatment.
There has been a correlation between liver damage due to cholestatic hepatitis and jaundice and ampicillin/sulbactam. Patients must be recommended to contact the doctor if there are signs and symptoms of liver disease (see side effects).
Due to single leukemia derived from viruses, ampicillin should not be used. High proportion of patients with mononoculatocalt hyperpses using ampicillin has been rash.
should be checked periodically to detect systemic dysfunction during prolonged therapy; This includes kidney, liver and hematuria function.
The main elimination sugar of sulbactam and ampicillin after drinking is through urine. Because the kidney function is not fully developed in firstborn babies when using sultamicillin in infants should consider this.
Patients with rare genetic problems such as galactose intolerance, Lapp lactase deficiency or Glucose-Galactose should not use this drug.
The ability to drive and operate machinery
There is no evidence of the effect of the drug on the ability to drive and operate machinery.
Pregnancy
Studies on reproductive animals shows that sultamicillin reduces the fetal fertility or harmful to fetus. Sulbactam passes through the placenta. However, safety when used during pregnancy in humans has not been determined. Therefore, sultamicillin should only be used during pregnancy if the benefits are greater than the potential risk.
Breastfeeding period
should not use sultamicillin during breastfeeding. Ampicillin and sulbactam concentrations are excreted in milk, which should be considered because babies can be exposed, especially when the kidney function has not been fully developed in infants.
Drug interaction
allopurinol
Simultaneous use of allopurinol and ampicillin significantly increases the rate of skin rash in patients taking both drugs compared to the patient group only taking ampicillin only.
anticoagulants
Estrogen -containing birth control pills
There has been a report on decreased contraceptive effectiveness in women using ampicillin, leading to unwanted pregnancy. Despite its low possibility, patients should be provided with an optional to use an alternative or additional contraceptive method while using ampicillin.
methotrexate
Simultaneous use with penicillin reduces the clearance and increases the toxicity of methotrexate. Patients should be closely monitored. Leucovorin dose may be increased and extended the use time.
Probenecid
Probenecid reduces the secretion of ampicillin and sulbactam through the renal tubules when used simultaneously, this effect increases and pulls the antibiotic concentration in serum. Extend the sale time and increase the risk of poisoning.
Interaction in labo
Positive positive urinary glucose can occur in urine analysis tests with Benedict reagent, fehling and clinitest reagent.
After giving pregnant women ampicillin, noticing the concentration of assembled estriol, estriol glucoronid, combined ester and estradiol in plasma are temporarily reduced. This effect can also occur with sodium sulbactam/sodium ampicillin intravenous intravenous intravenous injection.
Storage
at temperatures below 30 ° C. Avoid light.
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