Sullivan Davipharm medicine to treat schizophrenia (4 blisters x 7 tablets)

Dosage form Box of 4 blisters x 7 tablets
Specifications Amisulpride

Ingredient

Composition information	Content
Amisulpride	100mg

Uses

Indications

Sullivan 100 is indicated for treatment in the following cases:

Disease schizophrenia acute and chronic symptoms, for example, paranoia, hallucinations, thought disorders or negative symptoms Example: withdraw from social life. D1, D4, and D5. Amisulprid also has no affinity for the serotonin receptor, Alpha Andrenergic, histamine H1, Cholinergic, AmisulPyRrid is not attached to the Sigma position.

Amisulprid receptor blocking D2/D3, Synap money, causing dopamine release, effective for symptoms of schizophrenia.

Dynamic pharmacy

absorption: After taking 1 dose of 50 mg, Amisulprid has two absorption vertices. After 1 hour after drinking (the concentration of theemonemia is 39 ± 3 ng/ml), after taking 3-4 hours (the concentration is 54 ± 4 ng/ml). Absolute bioavailability is 48%.

Distribution: The distribution volume is 5.8 l/kg, low cohesion with plasma proteins (16%).

Metabolism: about 4% of the dose is converted into non -activity substances.

Elimination: The sale time is about 12 hours. Elimination mainly through urine in non -changing form.

Before taking Sullivan Davipharm medicine to treat schizophrenia (4 blisters x 7 tablets)

How to use

Sullivan 100 oral use. Take whole tablets with water, do not chew tablets.

Take medicine before meals. If you feel the effect of the drug is too strong or too weak, do not arbitrarily change the dose, notice and consult your doctor.

Dosage

Dosage from 300 mg/day or less: Take 1 time/day.

Dosage of over 300 mg/day: divided into 2 times/day.

Acute phase: 400 - 800 mg/day. In some cases, the dose may increase to 1200 mg/day. Adjust the dose according to the patient's response.

Maintain the lowest dose effectively.

For patients with both types of negative and positive symptoms, the dose should be adjusted to optimize positive symptoms.

For patients mainly negative symptoms, the dose should be used in the range of 50 - 300 mg/day.

Should use the lowest dose effectively.

Elderly: Amisulprid's safety has been studied in some elderly people. Amisulpid should be used carefully due to the risk of hypotension and sedation.

Children: Safe and effective of Amisulprid from puberty to 18 years of age has not been studied.

Data on the use of amisulprid in adolescents with schizophrenia is still small. Therefore, it is not recommended for children from puberty to 18 years of age, contraindicated for children before puberty because there is no data on safety and efficiency for this age group.

Renal failure: Amisulprid is eliminated through the kidneys.

Patients with creatinine clearance about 30 - 60 ml minutes: Take 1/2 dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.Làm gì khi dùng quá liều?

Triệu chứng quá liều: Buồn ngủ, hôn mê, hạ huyết áp và triệu chứng ngoại tháp. Cases of death are often reported when used simultaneously with other anti -psychotic drugs.

In case of acute overdose, it is advisable to consider the ability to use multiple drugs at the same time.

Dialysis is not effective for amisulprid overdose. There is no specific antidote. Monitoring patients and taking appropriate physical support measures. If there is severe foreign symptoms, cholinergic drugs should be taken. Monitor electrocardiograms due to the risk of extending the QT until the patient recovers.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Sullivan 100 , you may experience unwanted effects (ADR).

Very common, ADR> 1/10

Neurological: Run, spasticity, movement disorders, increase salivation.

Common, ADR> 1/100

Neurological: abnormal body movement uncontrolled (twisting neck, eye rotation, jaw hard), drowsiness.

Mental: Insomnia, restlessness, anxiety, orgasm. digestive: constipation, nausea, vomiting, dry mouth .

Endocrine: Increasing prolactin levels can recover after stopping the drug, causing increased milk secretion, amenorrhea, female mammary glands, breast pain, and erectile dysfunction.

Cardiovascular: Hypotension.

Test results: weight gain.

Uncommon, 1/1000

Neuroscope: Major exercise mainly in the tongue and/or face, convulsions.

Metabolism and nutrition: hyperglycemia. Cardiovascular: Slow heart rate.

Test results: Increased liver enzyme, mainly transferase. immune: Hypersensitivity reaction.

Not determined frequency

Hematology: leukopenia, neutropenia, granular leukopenia.

Metabolism and nutrition: Increased triglycerides and blood cholesterol.

Mental: Confusion.

Neurological: Malignant sedative syndrome is likely to be fatal. Heart: extends the QT interval and ventricular arrhythmia such as arrhythmia, fastest, can lead to ventricular or cardiac arrest, sudden death.

Circuit: Case of strong blockage of thrombosis, including pulmonary embolism.

Skin and subcutaneous tissue: Evaluation, urticaria.

Pregnancy, postpartum and the last months of pregnancy: The syndrome of cessation in infants.

Instructions on how to handle ADR: notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Sullivan 100 contraindicated in the following cases:

Patients with hypersensitivity to any component of the drug.

Pro -dependent prolactin such as breast cancer, pituitary tumor.

Chrome cells.

Children under 15 years old (before puberty).

Pregnant women, nursing women.

Not coordinated with the following drugs because it can cause heart torsion: Quinidin, disopyramid, processaramid, amiodaron, sotalol, bepridil, cisaprid, sultorid, thioridazin, erythromycin intravenously, venomnin intravenous injection, halofantrin, pentamidin, sparproxacin, sparfloxide Levodopa.

Precautions when used

as well as other neuroleptics, malignant neurological syndrome (high fever, muscle hardness, plant neurological disorders, CPK increases ...). When high fever, especially when taking high doses, it is necessary to stop using all mental drugs.

Hyperglycemia: has been recorded in patients treated with non -typical anti -psychotic drugs, including Amisulprid, so the patient has been diagnosed with diabetes or risk of diabetes when starting to treat with Amisulprid should closely monitor blood sugar.

renal failure: Amisulprid is eliminated through the kidneys, so the dose adjustments need to be adjusted in patients with renal impairment (see the dose section).

Epilepsy: Amisulprid lowered the epilepsy threshold. Should be cautious with patients with a history of epilepsy.

Elderly patients: Like other sedatives, so they are especially cautious in elderly patients due to the risk of hypotension and sedation. The patient's renal function may be reduced.

Parkinson: only use Amisulprid for Parkinson patients when really necessary, because it can worsen Parkinson's condition.

Symptoms of acute cessation include nausea, vomiting and insomnia have been described after stopping a sudden sudden sedation. The recurrence of mental symptoms can also occur and the occurrence of non -autonomous movement disorders have been reported. Therefore, when you want to stop using, gradually reduce the dose, avoid sudden stopping.

Amisulprid extends the QT range, which is at risk of severe ventricular arrhythmia such as twisting if the disease has previously been slow heart rate (less than 55 beats/ minute), reduced potassium, congenital QT interval.

In randomized clinical studies compared to the Placebo group in the elderly population group with memory decline and treated with typical anti -psychotic drugs, the risk of cerebral vascular events tripled and unknown mechanism. This possibility is not possible to occur when using other anti -psychotic drugs or in other population groups. Caution should be used with amisulprid in patients at risk of stroke

Older people impaired memory:

Elderly memory losses treated with psychotic drugs are at higher risk of death. In patients using the drug is 4.5%, compared to 2.6% in the group using Placebo. Although there are many causes of death in clinical research using non -typical anti -psychotic drugs, most of the causes are caused by cardiovascular disease (such as heart failure, sudden death) or infection (such as pneumonia).

Tasiacinoma: Some cases of vasica (VTE) have been reported in patients using anti -psychotic drugs. Because patients treated with anti -psychotic drugs often suffer from VTE risk factors, all VTE risk factors should be identified before, during and after using Amisulprid.

Breast cancer: Amisulprid increases prolactin levels. Therefore, be careful in patients with a history or family history of breast cancer.

Hematoma: leukopenia, neutropenia and granulocytopenia have been recorded with anti -psychotic drugs, including Amisulprid. Infectious infections or fever may be evidence that the drug affects blood and is needed immediately blood tests.

The ability to drive and operate machinery

Even when using the doses as recommended Amisulprid can still cause drowsiness, drowsiness, affecting the ability to drive and operate machinery. Should be cautious.

Pregnancy

In animals, Amisulprid does not show reproductive toxicity. It has been observed that reducing fertility (related to pharmacological effects causing increased prolactin secretion of the drug). No monster effect of Amisulprid.

Clinical data used for pregnant women is limited. Therefore, safety in pregnant women has not been established.

It is not recommended to use drugs during pregnancy unless the benefits are superior to the risk.

Women who are likely to be pregnant should talk to the doctor about effective contraception before using the drug.

Babies exposed to anti -psychotic drugs (including amisulprid) in the last 3 months of pregnancy are at risk of side effects including symptoms of outsiders and/ or symptoms of quitting drugs with different severity and time. There have been reports of symptoms such as excitement, spasticity, reduced tone, tremor, drowsiness, respiratory failure or eating disorders. Therefore, babies need to be carefully monitored.

Breastfeeding period

unknown Amisulprid is excreted in milk or not, contraindicated for breastfeeding women.

Drug interaction

Contraindicated in combination with the following drugs

IAA anti -arrhythmic drugs such as Quinidin, Disopyramid, Procainamid.

Anti -arrhythmia group III such as Amiodaron, Sotalol.

Medications such as Bepridil, Cisaprid, SultoPrid, Thioridazin, Erythromycin intravenously, intravenous venomin, halofantrin, pentamidin, sparfloxacin.

levodopa.

Do not coordinate: Amisulpidi increases the effects of alcohol on central nerves.

Be careful when coordinating

Medications increase the risk of heart torsion:

Medications that slow heart rate such as beta receptor blockers, calcium channel blockers such as diltiazem, verapamil, clonidin, guanfacin, digitalis.

Medications that cause hypokalemia: Diuretics lower potassium potassium, laxative stimulants, amphoticin b intravenously, glucocorticoid, tetracosate.

Neurological drugs such as Pimozid, Haloperidol, Imipramin, Lithium.

Should consider when coordinating

Central neurological inhibitors such as sedatives, anesthesia, analgesics, H1 antihistamines cause drowsiness, barbiturat, benzodiazepine and other anti -anxious drugs.

Antid for hypertension or drugs that cause hypotension.

Dopamine beneficiaries (such as levodopa): because of the effect of Amisulprid.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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