Sulpiride Vidipha Treatment Treatment of schizophrenia (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Sulpiride

Ingredient

Composition information	Content
Sulpiride	50mg

Uses

indications

Sulpidi 50 mg vidipha drug is indicated in the following cases:

Treatment of acute and chronic schizophrenia. Sulpiride can be considered as an intermediate medication between neuroleptic and antidepressants, because sulpiride has both of the effects.

Sulpiride is mainly used to treat psychosurine diseases such as schizophrenia. The mood increases after a few days of treatment, accompanied by losing all the frantic symptoms of the disease. Sulpiride does not cause drowsiness and loss of emotions like when using classic neuroleptics such as phenothiazine or butyrophenone.

Sulpiride is highly doses that control the positive symptoms of mental illness but low doses have the effect of active, agile for people with indifferent schizophrenia, cowering without contact with society.

Although there are some characteristics of classic neurolysis, sulpiride different from those drugs in terms of chemical structure and non -closing posture, does not affect the adenylcyclase system sensitive to dopamine, does not affect Noradrenaline and 5 - HT rotation, almost no anti -cholinesterase effect, does not affect Muscarinic receptors or GABA.

Pharmacokinetics

absorption

Sulpiride absorbs slowly through the gastrointestinal tract, low bioavailability and depending on the individual. The peak concentration of Sulpiride reaches 3-6 hours after taking 1 dose.

Distribution

The drug is quickly distributed into the tissue, through breast milk but through the blood -brain barrier. The drug is associated with low plasma proteins (

Elimination

Eliminating drugs through urine and feces, mainly in the form of unprovered (about 95%). The sale time of drugs is about 8 - 9 hours.

Before taking Sulpiride Vidipha Treatment Treatment of schizophrenia (10 blisters x 10 tablets)

How to use

oral medication.

Dosage

adults

Symptoms negative of schizophrenia

Initially, take 200 - 400 mg/time, twice a day, if necessary, the maximum dose can be increased to 800 mg/day.

Positive symptoms of schizophrenia

400 mg/time, 2 times a day. Gradually increase the dose to up to 1200 mg/time, 2 times a day.

Symptoms of yin and positive combination

400 - 600 mg/time, 2 times a day.

Mental disorders accompanied by stomach ulcers

150 mg/day, use 4 - 6 weeks.

Children

Children over 14 years old: Take 3 - 5 mg/kg/day.

Children under 14 years of age: No instructions.

Elderly

Dosage like adults, but the starting dose is always low and increases gradually. Starting 50 - 100 mg/time, 2 times a day, then increases to the effective dose.

Dosage for people with kidney failure

Must reduce the dose or increase the distance between drug use depending on the clearance of creatinine:

Creatinine clearance 30 - 60 ml/minute: 2/3 of the normal dose.

Creatinine clearance 10 - 30 ml/minute: 1/2 normal dose.

Creatinine clearance below 10 ml/minute: 1/3 of the normal dose.

or may increase the distance between the dose is 1.5; 2 and 3 times compared to normal people. However, in case of medium and severe renal failure should not use sulpiride if possible.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Clinical symptoms vary depending on the dose:

The dose of 1 - 3 g can cause a gloomy, restless and rare state of foreign symptoms. Symptoms of coma when using high doses may last up to 4 days. If you are new to medication, you should wash your stomach, drink activated carbon, alkaline urine to increase excretion. If necessary, Parkinson's syndrome can be used and use supportive treatment and symptomatic treatment.

What to do when you forget 1 dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Sulpidi 50 mg Vidipha, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: Insomnia or drowsiness.

Endocrine: increased blood prolactin, increased milk secretion, menstrual disorders or amenorrhea.

Uncommon, 1/1000

Neurology: excessive stimulation, pagoda syndrome, Parkinson's syndrome.

Cardiovascular: prolonged qt range (causing arrhythmia, torsion).

Rare, ADR

Endocrine: Big breasts in men.

Neurological: late dysplasia, Malignant high fever syndrome caused by neuroleptic.

Cardiovascular: Hypotenary pressure vertical, slow heart rate or arrhythmia.

Mile liver: jaundice due to bile stasis.

Other ADRs: lower body temperature, sensitive to light.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when taking the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Sulpidi 50 mg Vidipha is contraindicated in the following cases:

Hypersensitivity to sulpiride.

adrenal marrow.

Porphyrin metabolic disorders.

The central nervous state is inhibited, comatose, alcohol poisoning and neurological inhibitors.

Pregnant and lactating women.

Precautions when using

renal failure: need to reduce the dose and increase monitoring. If the renal failure is severe, it is recommended to treat each interrupt batch.

Need to strengthen monitoring of the following objects:

People with epilepsy because they are likely to be lowered. Low -dose sulpiride can cause severe symptoms.

The ability to drive and operate machinery

avoid using the drug when driving and operating machinery.

Pregnancy

Like other neuroleptic drugs, sulpiride through the placenta can cause unwanted effects on the fetus's nerves, so it should not be used during pregnancy, especially in the first 16 weeks.

The period of breastfeeding

Sulpiride is distributed into breast milk in relatively large amounts and can cause unwanted reactions for breastfed babies. So do not use medication or stop breastfeeding if taking the medication.

Medicinal interaction

Sucralfate or antacids containing aluminum or Magnesi hydroxide reduces sulpiride absorption. So use sulpiride after taking these drugs for 2 hours to avoid interactions.

Lithium: Increasing the ability to cause slanting dysfunction of sulpiride may be due to lithium that increases the ability to attach sulpride to the dopaminergic d2 receptor in the brain.

Alcohol increases the sedative effects of the drug, so avoid drinking alcohol and alcoholic drinks when taking the drug.

Sulpiride may increase the effect of lowering blood pressure when used with high blood pressure medications and can cause vertical hypotension, so when combined, it should be noted.

Other central neurological inhibitors: Increasing neurological inhibition effects can cause bad consequences, especially drivers and machinery, so it should be noted when coordinated.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

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