Sulpragi Agimexpharm medicine for anxiety treatment (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Sulpiride

Ingredient

Composition information	Content
Sulpiride	50mg

Uses

indications

Sulpragi 50 mg drug is indicated in the following cases:

Short -term treatment of anxiety symptoms in adults when not responding to standard treatments. Benzamid, anti -mental disorders through the selective block of Dopamine D2 receptors in the brain. Sulpides can be considered as an intermediate medication between neuroleptic and antidepressants, because sulpides have both of them.

Sulpidi is mainly used to treat psychosurine diseases such as schizophrenia. The mood increases after a few days of treatment, accompanied by losing all the frantic symptoms of the disease. Sulpidi does not cause drowsiness and emotional loss like when using classic neuroleptics such as phenothiazin or butyrophenon.

high doses of high doses control the positive symptoms of schizophrenia but low doses have a active, agile effect on people with indifferent schizophrenia, cowering without social contact. Although there are some characteristics of classic neuroleptics, sulpiders are different from those drugs in terms of chemical structure and does not cause the position to keep the posture, does not affect the adenylcyclase system sensitive to dopamine, does not affect Noradrenalin and 5-HT rotation, almost no anti-cholinesterase effect, does not affect Muscarinic or GABA receptors.

Dynamic pharmacokinetics

Sulpidi slowly absorbed through the digestive tract, low bioavailability and depending on the individual. The peak concentration of Sulpidi is reached from 3 to 6 hours after taking 1 dose.

Quickly distributed into the tissue, through breast milk but through poorly brain barriers. The drug is linked to low plasma proteins (40%). Eliminated drugs in urine and feces, mainly in the form of unprovered (about 95%). Half life eliminated about 8-9 hours.

Before taking Sulpragi Agimexpharm medicine for anxiety treatment (3 blisters x 10 tablets)

How to use and dose

Short -term treatment of anxiety symptoms in adults:

Take 50 - 150 mg/ day, divided into doses, use up to 4 weeks.

Severe behavioral disorders in children over 6 years old:

Take 5 - 10 mg/kg/day.

acute and chronic schizophrenia:

Adults:

Symptoms of negative mental mental illness: Starting oral 200 - 400 mg/time, twice a day, if necessary, the dose can be increased to maximum of 800 mg/day.

Positive symptoms of schizophrenia: Take 400 mg/time, 2 times a day. Increase the dose to up to 1200 mg/time, 2 times a day.

Symptoms and positive combinations: Take 400 - 600mg/time, 2 times a day.

Children:

Children over 14 years old: Take 3 - 5 mg/kg/day.

Children under 14 years of age: No instructions.

Elderly:

Dosage for the elderly is the same as adults, but the starting dose is always low and increasing. Starting 50-100 mg/time, 2 times a day, after increasing to effective dose.

People with kidney failure:

Must reduce the dose or increase the distance between drug use depending on the clearinine clearance.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Therefore, if you are new to medication, you should wash your stomach, drink activated carbon (the drug causes no effect), alkaline urine to increase the discharge of the drug. If necessary, Parkinson's syndrome can be used and use other supportive treatments and treatment.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Sulpragi 50 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: insomnia or drowsiness.

Endocrine: increased blood prolactin, increased milk secretion, menstrual disorders or amenorrhea.

Uncommon, 1/1000

On the nervousness: excessive stimulation, extracurricular syndrome (restless sitting, crooked neck, eye rotation), Parkinson's syndrome.

On the heart: The long range of qt (causing arrhythmia, torsion).

Rare: 1/10000

On endocrine: Big breasts in men.

In the nerves: late dysplasia, Malignant high fever syndrome due to neuroleptic.

In blood pressure: Hypotenary pressure vertical, slow heart rate or arrhythmia.

Other: lower body temperature, sensitive to light, jaundice due to cholestasis

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Sulpragi 50 mg drug is contraindicated in the following cases:

Hypersensitivity to sulpides or any ingredients of the drug.

The patient has identified or suspected the adrenal pulp (due to the risk of severe high blood pressure stroke).

Porphyrin metabolism disorders.

The central nervous state is inhibited, comatose, alcohol poisoning and neurological inhibitors.

Tumor depends on prolactin secretions such as pituitary tumors, breast cancer.

Not for pregnant and lactating women.

Be cautious when using

While treating with sulpress, if you see high fever for unknown reasons, it is necessary to stop the drug immediately because high fever may be a manifestation of malignant syndrome due to neuroleptic.

Sulpidi extends the QT range, depending on the dose. This effect increases the risk of heavy arrhythmia, especially the top, especially when there is a bradycardia

Must monitor blood glucose for people with diabetes or risk diabetes when starting treatment with sulpid.

In cases of renal failure, sulpider dose is needed and increased monitoring. If the renal failure is severe, it is recommended to treat each interrupt batch.

Need to strengthen monitoring of the following objects:

People with epilepsy because they are likely to be lowered.

The ability to drive and operate machinery

Patients using drugs should avoid driving and operating machinery because drugs can cause drowsiness.

Pregnancy

Similar to other sedatives, sulpides through the placenta can cause unwanted effects on the fetus's nerves, so do not use drugs during pregnancy especially in the first 16 weeks.

Lactation period

Sulpidi is distributed into breast milk in relatively large amounts and can cause unwanted reactions for breastfed babies. Therefore, women who are breastfeeding should not be used or stop breastfeeding if taking the drug.

Medicinal interaction

Sucralfate or antacids containing aluminum or Magnesi hydroxyd reduces sulpidi absorption. Therefore, Sulpidi should be used after taking antacids for about 2 hours to avoid interaction.

Lithi: Increases the likelihood of causing extrasic dysfunction of sulpides may be due to lithium that increases the ability to attach sulpides to the Dopaminergic D2 receptor in the brain.

Levodopa: Antagonism competes with sulpides and sedatives, so contraindicated coordination Sulpida with Levodopa.

With antihypertensive drugs: can increase the effect of hypotension and can cause hypotension, so be aware of when coordinated.

Alcohol increases the sedative effects of the drug, so avoid drinking alcohol and alcoholic beverages while using sulpides.

Other central neurological inhibitors: Increasing neurological inhibition effects can cause bad consequences, especially drivers and machinery operators. Therefore, it should be noted when coordinated.

Storage

Store in a dry place, no more than 30 ° C.

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