Sumakin 750 mekophar treatment for otitis media, sinusitis (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxicillin, sulbactam

Ingredient

Composition information	Content
Amoxicillin	500mg
Sulbactam	250mg

Uses

Indications

Sumakin 750 drug is indicated for treatment of sensitive bacterial infections:

Oral and respiratory infections: otitis media, sinusitis, tonsillitis, sore throat, laryngitis, tracheitis, pneumonia, bronchitis ... (especially in severe or recurrent cases).

Abdominal infections, gynecological infections.

Urinary tract infections: Especially in cases of recurrent or complicated cystitis.

Skin infections and soft tissue: lymphatic vasculitis, cellular inflammation, open wounds or tissue loss, tooth abscess and mouth due to staphylococcus aureus.

Pharmacy

Sumakin 750 is a drug that has a bactericidal effect on amoxicillin-sensitive bacteria, amoxicillin combination with sulbactam in a 2: 1 ratio that helps amoxicillin is not destroyed by Beta-Lactamase. The mechanism of action of amoxicillin is inhibiting the protein biosynthesis of bacterial cell walls, leading to killing bacteria. The drug has a bactericidal effect during the division of sensitive bacteria.

Sulbactam is an unfavorable competitive inhibitor with beta-lactamase.

This combination has a power that increases the effect and expands the antibacterial spectrum of amoxicillin with the Beta-Lactamase bacteria:

Gram-positive bacteria: Streptococcus pneumoniae, Streptococcus Pyogenes, Streptococcus Faecalis (Trainbon Bridge), Streptococcus Viridans, Staphylococcus aureus (including Beta-lactamase bacteria), Staphylocus Epidmidmidmids (capacitor hemolysis), Staphylococcus saprophyticus.

Gram -negative bacteria: Neisseria gonorrhoeae, Moraxella Catatrhalis, acinetobacter strains.

Gram -negative bacilli: Hemophilus Influenzae, E. Coli, Proteus Mirabilis, Klebsiella strains include Klebsiella Pneumoniae, Entobacter strains.

Anaerobic bacteria: Clostridium strains, peptococcus strains, peptostreptococcus strains, bacteroides including B. Fragilis.

Helicobacter: Helicobacter pylori.

pharmacokinetics

Amoxicillin

Absorption: Amoxicillin amount absorbed when taken is approximately 80% and does not affect food. The average peak concentration in serum is about 1-2 hours after drinking.

Distribution: Amoxicillin is allocated most of the tissues in the body and biological fluids, the concentration of treatment is achieved in bronchial secretions, sinus nose and amniotic fluid, saliva, fluid, cerebrospinal fluid, secretion of secretions in the membranes and middle ears. About 20% of the drug is bound to the protein of plasma. Amoxicillin passes the fetus fence and is excreted into breast milk.

Metabolism and elimination: The drug is excreted mainly in the form of activity (70 - 80%) and into bile fluid (5 - 10%). In people with normal kidney function, the average serum cancellation time is approximately 1 hour.

sulbactam

Absorption: When using sulbactam on the gastrointestinal tract, the bioavailability of the drug is almost 100%, but if used by oral absorption of the gastrointestinal tract is incomplete. In order to improve the absorption ability, some of the synthesized precursors, among them, Pivoxil Sulbactam has the best absorption ability. The pharmacokinetics of sulbactam are similar to Amoxicillin and when they use simultaneously determine that there is no dynamic interaction between the drugs. The peak concentration of Sulbactam's serum also achieved the same time as amoxicillin and the peak concentration values also depend on the dose.

Distribution: The ratio of cohesion in plasma proteins is approximately 40%. The drug also passes through the fetus and is excreted into breast milk.

Metabolism and elimination: Sulbactam is mainly excreted in the urine in the form of unchanged (75 - 85%). The half -life of the drug in serum is approximately 1 hour, for patients with severe renal impairment, the excretion of the drug will slow down.

Before taking Sumakin 750 mekophar treatment for otitis media, sinusitis (2 blisters x 7 tablets)

How to use

Sumakin 750 medicine for oral use.

Dosage

The usual dose for adults and children over 12 years old: 1 Sumakin 750 tablet every 8 hours.

Patients with renal impairment: The dose must be reduced according to creatinine clearance coefficient.

CLCR

Patients with hemolysis: 500 mg every 24 hours and an additional dose of supplements after fertilizer.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? In case of overdose, stop taking the drug immediately and use supportive treatments. Can cause vomiting, gastric lavage if newly overdosed, unless contraindicated.

There is no specific antidote, which can be removed by hemolysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Sumakin 750, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: nausea, vomiting, diarrhea, indigestion, epigastric pain ...

Rare, ADR

Allergic reactions: urticaria, rhymes, lumpy, respiratory disorders and rarer may experience anaphylaxis, Stevens-Johnson syndrome, diverse erythema and poisoned epidermal necrosis.

Kidney and urinary: interstitial nephritis.

Hematology: Anemia, platelet disorders, leukocytes, eosinophilia prefer eosin, leukopenia and granulocytes. liver: liver dysfunction. Systemic: Candida infection in the mouth or in another position is a manifestation of bacterial balance transformation. nerve: increase activity, anxiety, insomnia, behavior change. digestive: fake intestinal inflammation.

Instructions on how to handle ADR: notify your doctor unwanted side effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Sumakin 750 drug contraindicated in the following cases:

Patients with a history of allergies to penicillin or cephalosporins and sulbactam or any ingredients of the drug. There is a history of gastrointestinal disease. Bacterial infections have monon cell leukemia. Infection with herpes virus, being treated with Allopurinol.

Pregnant and lactating women.

Caution when using

Patients with Sumakin 750 treatment may have fungal infections or other pathogenic bacteria (mainly due to pseudomonas or candida). If superinfection appears should be discontinued and applied appropriate treatments.

During the treatment of Sumakin 750 may appear to increase the transaminase indicators of the liver, mainly glutamic-oxalacetic transaminase, should periodically check the liver, kidney and bone marrow function if using Sumakin 750 extended.

Be cautious when used for patients being treated with Lyne, Sulfone syndrome may occur.

A slightly reduction in the concentration relationship between estriol and estrone with estradiol content in serum. The contraceptive support should be used for female patients who are applying Estrogen or Progestin contraception.

Caution for the elderly, children, pregnant and lactating women.

The ability to drive and operate machinery

Caution for drivers and operating machinery.

Pregnancy

Precautions for pregnant women because human studies have not been conducted.

Breastfeeding period

Caution for breastfeeding women because of the unexplained human studies.

Drug interaction

simultaneously with Allopurinol increases the risk of skin allergies.

Probenecid may increase blood levels because this drug will be reduced in the kidneys when used simultaneously.

chloramphenicol, macrolide, sulfonamide and tetracycline can hinder the bactericidal effect of penicillin.Clinical

amoxicillin can affect the value of total serum protein or a false positive reaction in the glucose test in water pepper by color reaction. High amoxicillin levels can reduce blood glucose.

Storage

In a dry place, avoiding light, the temperature does not exceed 30 ° C.

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