Sunapred 20mg Donaipharm anti -inflammatory and anti -allergic drug (30 tablets)

Dosage form Box of 30 tablets
Specifications Prednisolone

Ingredient

Composition information	Content
Prednisolone	20mg

Uses

Indications

Sunapred 20 mg bottle of 30 tablets are indicated for anti -inflammatory, anti -allergic and immunosuppressive inhibitors.

Rheumatoid arthritis, whole body lupus, some forms of vasculitis, temporal arteritis and node artery inflammation, sarcoid disease, bronchial asthma, ulcerative colitis, hemolytic anemia, granular leukemia, and severe allergic diseases.

Cancer, such as acute leukemia, lymphoma, breast cancer and prostate cancer at the end.

Pharmacology

Prednisolon is synthetic corticosteroid, mainly used due to anti -inflammatory, anti -allergic and immunosuppressive effects. Metabolic effects and holding salt, water are lower than hydrocortison.

Prednisolon has weak mineralocorticoid effects, so if you take the drug in a short time, there is very little risk of keeping Na+ and edema. Anti -inflammatory effects of prednisolon compared to other glucocorticoids: 5 mg Prednisolon are valid equal to 4 mg methylprednisolon and equal to 20 mg of hydrocortison.

Dynamic pharmacokinetics

Oral bioavailability of Prednisolon approximately 82%. Plasma peak concentration reaches 1-2 hours after taking the drug. Prednisolon binds to protein about 90 - 95%. The clearance of Prednisolon is 8.7 ± 1.6 ml/min/kg. The distribution of the drug is 1.5 ± 0.2 liters/kg. Prednisolon is metabolized in the liver and the metabolites are the form of sulfate and glucuronid ester excreted into the urine. The half -life of Prednisolon is approximately 1.7 - 2.7 hours.

Before taking Sunapred 20mg Donaipharm anti -inflammatory and anti -allergic drug (30 tablets)

How to use

Take oral use. Take medicine when full and drink with plenty of water.

Dosage

sugar and prednisolon dosage and derivatives dependent on the disease need to be treated as well as the patient's response. The dosage for children and children must rely on the severe condition of the disease and the patient's response rather than accurately rely on the dosage of instructions according to age, weight or body area.

After achieving the desired response, it is necessary to gradually reduce the dose to the extent that it is still appropriate to maintain the appropriate clinical response. The patient must be constantly monitored to adjust the dose when necessary, for example, remission or increased or stress (surgery, bacterial infection, trauma). When needed for Prednisolon for a long time, it is advisable to consider the Japanese -way medication regimen, only once in the morning in the natural rhythm of corticosteroid. This will be less ADR because there is a recovery time between 2 doses. After long -term treatment must stop Prednisolon gradually.

The starting dose for adults can be from 5 - 60 mg/day, depending on the disease needed to be treated and usually divided into 2-4 times daily.

Dosage for children can from 14 2 2 mg/kg/day or 4 - 60 mg/m2/day, divided into 4 times.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? In this case, it is necessary to consider to make the right decision to suspend or stop using Glucocorticoid.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Sunapred 20 mg bottle 30 tablets, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nerve: insomnia, nervousness is easily agitated.

digestion: Increase appetite, indigestion.

Skin: him.

Endocrine and metabolism: Water and electrolyte disorders, diabetes.

nervous - muscle and bone: joint pain. eyes: cataract, glaucom.

Uncommon, 1/1000

Central nerve: dizziness, convulsions, mental disorders, fake brain, headache, mood change, delirium, hallucinations, refreshment.

Cardiovascular: edema, hypertension, heart failure may occur.

skin: acne, skin atrophy, hyperpigmentation, bruising.

Endocrine and metabolism: Cushing syndrome, Online inhibition of Yen - adrenal, slow growth, glucose intolerance, reduced potassium, alkaline contamination, amenorrhea, keeping salt, hyperlem of blood glucose.

digestion: Peptic ulcer, nausea, vomiting, esophageal ulcer, pancreatitis.

Neurological - muscle and bone: muscle weakness, muscle atrophy, fracture osteoporosis. immune: impaired immune function, slow healing wounds and increased infection power.

Other: Hypersensitivity reaction.

Instructions on how to handle ADR

After a long -term treatment with glucocorticoid, there is a possibility of inhibiting the hypothalamus - pituitary - adrenal gland, so it is imperative to reduce the dose of glucocorticoids step by step, instead of sudden stop. Prednisolone dose reduction process may be applied: every 3-7 days of 2.5 - 5 mg, until the physiological material Prednisolon is approximately 5 mg. If the disease is worse when it is reduced, increasing the dose of prednisolon and then reducing the prednisolon dose slowly.

Apply continuous treatment to avoid drugs with pharmacological effects. Using a single dose of the day causes less ADR than the doses of the day, and Japanese insulation is a good measure to minimize the inhibition of adrenal glands and minimize other ADRs. In Japanese therapy, every two days of using a single dose, in the morning.

Preventive gastric and duodenal ulcerative prophylaxis with antihistamine H2, or proton pump inhibitors when using high -dose corticosteroids.

All long -term patients with glucocorticoids need additional calcitonin, calcitriol and supplementing calcium to prevent osteoporosis.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Sunapred 20 mg bottle of 30 tablets contraindicated in the following cases:

Hypersensitivity to any ingredient of the drug.

Severe bacterial infections, viral, fungal or tuberculosis infections, except for bacterial shock and meningitis.

Progressive stomach ulcers, mental illnesses, alcoholic cirrhosis, acute hepatitis.

is using a living virus vaccine.

Caution when using

Caution in people with osteoporosis, newly connected people (intestines, blood vessels), mental disorders, gastrointestinal ulcers, hypertension diabetes, heart failure and growing children.

Due to the risk of unwanted effects, it is necessary to use Prednisolon carefully for the elderly. Should use the lowest dose and in the shortest possible time.

Acute adrenal insufficiency may occur when the drug is stopped suddenly after a long time of treatment or when stressed.

When using high doses can affect the effects of vaccine vaccinations.

The ability to drive and operate machinery

No report.

Pregnancy

Take medication in a long -term systemic route for mothers can lead to weight loss in newborns. High doses for mothers may cause a small risk of reducing the adrenal product in newborns. Therefore, it is necessary to consider the benefits that can be achieved compared to the risk for mothers and children may occur when taking the drug.

It is necessary to use corticosteroids for pregnant women with asthma because asthma is dangerous to cause an oxygen deficiency for the fetus. Using glucocorticoid before premature birth also promotes lung growth for children, preventing respiratory decline syndrome.

breastfeeding period

Prednisolon secretes breast milk with less than 1% of the dose and may not be clinically significant. So be careful when taking medicine for nursing mothers.

Interactive drug

Prednisolon causes Cytochrom P450 enzyme and is the substrate of the P450 CYP 3A enzyme, so this drug affects the metabolism of Ciclosporin, Erythromycin, Phenobarbital, Phenytoin, Carbamazepine, Ketoconazole, Rifampicin.

Phenobarbital, Phenytoin, Rifampicin and diuretics decreased potassium can reduce Prednisolon's effectiveness.

Prednisolon can cause hyperlem of blood glucose, so it is necessary to adjust the insulin doses higher when shared.

Avoid simultaneous use of prednisolon with nonsteroidal anti -inflammatory drugs because it can cause peptic ulcer.

Storage

Leave a cool dry place, avoid light, temperature below 30 ° C.

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