Sunigam 300 Imexpharm medicine for rheumatoid arthritis, osteoarthritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Tiaprofenic Acid

Ingredient

Composition information	Content
Tiaprofenic Acid	300mg

Uses

Indications

Sunigam 300 drug is indicated in the following cases:

The drug is used for adults and children over 30 kg to relieve pain and inflammation in the following cases:

Musculoskeletal and joint disorders such as rheumatoid arthritis, osteoarthritis, degeneration of stiff vertebra, joint spondylitis.

Disorders around the joints such as fibrosis, epidemic inflammation.

Ofold the gangitis and other soft tissue inflammation, sprains and muscle tension.

Lumbar pain, pain and inflammation after surgery.

Other soft tissue lesions.

Pharmacy

Pharmacological group: Non-Stoid anti-inflammatory. ATC code: M01AE11.

Tiaprofenic acid is the derivative of propionic acid, belonging to the nonsteroidal anti -inflammatory drug group (NSAID). Tiaprofenic acid prevents the biosynthesis of protaglandin and is a non -selective antagonist of Bradykinin, Prostaglandin E2, Serotonin, Histamine, and Acetylcholin. Therefore, Tiaprofenic acid has an analgesic, antipyretic and anti -inflammatory effect.

Dynamic pharmacy

Tiaprofenic acid is absorbed through the gastrointestinal tract and reaches the peak concentration within 1.5 hours after drinking. The percentage of drugs associated with plasma proteins, about 98%. Tiaprofenic acid and its metabolites are eliminated in the urine as acyl glucuronide, a small part excreted in bile. The sale time of Tiaprofenic acid is short, about 2 hours.

Tiaprofenic acid can be passed through the placenta and toxic distribution into breast milk in small amounts.

Before taking Sunigam 300 Imexpharm medicine for rheumatoid arthritis, osteoarthritis (3 blisters x 10 tablets)

How to use

Take medicine with lots of water, can be taken during or after meals and divided into 2-3 times a day.

Should be treated in the shortest time with the lowest dose effective to minimize unwanted effects due to medication.

Dosage

Adults

Common dose is 300mg/time, 2 times/day.

Children over 30kg

Take 300mg/day.

Old people

Use a cautious medication for older patients because of the high risk of unwanted effects. Lowest dose is needed in the shortest time and must regularly monitor the gastrointestinal bleeding when starting treatment with NSAID.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose

Symptoms of Tiaprofenic acid overdose include: headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, diarrhea, disorientation, irritation, coma, drowsiness, dizziness, tinnitus, fainting, sometimes seizures. In the case of acute poisoning, it can lead to kidney failure and liver damage.

How to handle

Mainly symptomatic treatment.

Patients must be monitored for at least four hours after taking toxic doses.

Stomach or active carbon to prevent the absorption of the drug within an hour after taking the toxic dose.

closely monitor kidney and liver function.

If there is a regular or prolonged convulsions should be treated by intravenous diazepam intravenously and use other supportive treatments depending on the clinical condition of the patient.

What to do when forgetting a dose?

Not recorded.

Side Effects

When using Sunigam 300, you may experience unwanted effects (ADR).

Gastrointestinal tract: Including symptoms such as indigestion, nausea, vomiting, abdominal pain/upper abdominal pain, black stool, vomiting, appetite, heartburn, intestinal disorders (flatulence, diarrhea, constipation), gastritis, mouth ulcers, acute colitis and Crohn's disease. Pancreatitis has been reported, although very rare. There have been reports on cases of peptic ulcer, potential or progressive gastrointestinal bleeding, especially in the elderly and may lead to death.

Skin and subcutaneous tissue: rash, urticaria, itching, hemorrhage, hair loss, diverse pink rash and water glossy dermatitis (Stevens-Johnson syndrome or poisoned epidermal necrosis), light sensitive reaction.

The immune system: Hypersensitivity reaction has been reported after treatment with NSAID drugs. Non -specific allergic reactions, asthma, especially in allergies to aspirin and other NSAIDs, bronchospasm, shortness of breath, angioed, anaphylaxis have also been reported.

Blood and lymphatic system: thrombocytopenia, prolonging bleeding time, hemorrhage anemia.

Vestibular coating: dizziness, dizziness, tinnitus and drowsiness.

Central nervous system: headache.

Urinary tract: Pain or cystitis, difficulty urination, burning, bloody urination, water and salt, interstitial nephritis, nephrotic syndrome, kidney failure.

liver - bile: hepatitis, jaundice.

Side effects that have been reported but not specific to Tiaprofenic acid:

Gasmondic nervous system: optic neuritis, visual disorders.

Bone muscle and connective tissue: Perception.

Neurological: depression, confusion, hallucinations. Reports of aseptic meningitis (especially in patients with autoimmune system disorders such as systemic lupus, mixed connective tissue disease), with symptoms such as stiff neck, headache, nausea, vomiting, fever or disorientation.

Body: fatigue, discomfort.

blood and lymphatic system: neutropenia, granulocytosis, property anemia, hemolytic anemia. cardiovascular: edema, high blood pressure, heart failure, the risk of cardiovascular thrombosis (see more warning and caution when taking the drug).

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor the unwanted effects when using the drug or the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Sunigam 300 drug contraindicated in the following cases:

Hypersensitivity to Tiaprofenic acid or any ingredients of the drug:

People with a history of allergies (bronchial asthma, rhinitis, angioedema, urticaria) with Buprofen, aspirin and other nonsteroidal anti -inflammatory drugs.

People with progressive peptic ulcer, or have a history of gastrointestinal bleeding related to the use of NSAID drugs earlier.

People with hematuria heart failure, severe kidney failure or severe liver failure.

Patients with symptoms or are suffering from bladder and prostate disease.

People with a history of recurrent urinary tract disorders.

Pregnant women.

Children under 30kg.

Caution when using

Unwanted effects can be minimized by using the lowest doses to be effective in the shortest time to control symptoms. Patients treated with long -term NSAID must be closely monitored side effects.

Tiaprofenic acid should be used carefully for the following subjects: patients with chronic renal impairment, patients with arterial hypertension or heart failure, elderly people, patients with a history of liver failure.

Be cautious when taking the drug for patients who are or have a history of bronchial asthma related to NSAID.

Tiaprofenic acid can cause salt and water to lead to edema, so carefully monitor the amount of urine and kidney function in patients with a history of hypertension, heart failure, cirrhosis, kidney syndrome and in patients using diuretics.

Symptoms of urinary tract and cystitis have been reported when treated with biaprofenic acid and other NSAIDs. If the urinary symptoms such as difficulty urinating, night urinating or hematuria occurs, it is necessary to stop Tiaprofenic acid immediately and conduct urine analysis.

Gastrointestinal hemorrhage, ulcers or perforation of the stomach, can be fatal, have been reported to all NSAIDs with or without warning symptoms or a history of serious gastrointestinal diseases.

Be cautious when combining the treatment of biaprofenic acid with drugs that may increase the risk of ulcers or bleeding, such as oral corticosteroids, anticoagulants such as warfarin, serotonin selective inhibitors or platelet -like anti -platelets such as aspirin.

Serious skin reactions such as flaking dermatitis, Stevens-Johnson syndrome, poisoned diagnosis have been reported when taking NSAID drugs, although very rare. If symptoms appear such as skin rash, mucosal damage, or any signs of hypersensitivity, it is necessary to stop using Tiaprofenic acid immediately.

The use of Tiaprofenic acid can reduce fertility in women and are not recommended for women who are intending to get pregnant or those who are treating infertility.

There is a cross -allergic ability between aspirin and other NSAIDs (including biaprofenic acid). Patients with asthma, nasal polyps or chronic urticaria have a high risk of a highly allergic reaction. Therefore, do not use biaprofenic acid for these objects.

NSAIDs can interfere with platelet function, so it is necessary to take care of the medication in patients with cerebral hemorrhage and internal bleeding.

Treatment with NSAIDs can cause a decrease in the dose depends on prostaglandin and cause kidney failure.

Needs should be closely monitored when using NSAIDs for patients with a history of hypertension, mild congestive heart failure to medium because NSAID causes water and edema. Patients with uncontrolled hypertension, congestive heart failure, myocardial ischemia, peripheral artery disease, brain vessels should only be treated with Tiaprofenic acid after careful consideration.

In patients with systemic lupus erythematosus (SLE) and mixed connective tissue disorders can increase the risk of sterile meningitis when using NSAID.

Risk of cardiovascular thrombosis:

Non -steroid anti -inflammatory drugs (NSAIDs), not aspirin, use systemic tract, which can increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient does not have previous cardiovascular symptoms. Patients need to be warned of symptoms of serious cardiovascular events and need to see a doctor as soon as they appear. In order to minimize the risk of adverse incidents, Sunigam is required at the lowest daily doses in the shortest possible time as possible.

Pregnancy

Tiaprofenic acid through the placenta. The congenital abnormalities have been reported when treated with NSAID in humans, although low and unclear. Therefore, Sunigam should not be used for pregnant women.

Breastfeeding period

Tiaprofenic acid is present in breast milk with low concentrations (about 0.2% dose). Therefore, it is necessary to be cautious when using Sunigam for this object and to ensure the safety of breastfeeding, it is necessary to consider stopping medication in the mother or stop breastfeeding.

Medicinal interaction

heparin, hypoglycemic drugs and diuretics: Due to high binding tiaprofenic acid with plasma proteins, avoid simultaneous use with other drugs that also have this ability. Need to adjust the dose of hypoglycemic drugs, phenytoin and diuretics when combined with Tiaprofenic acid.

Anticoagulant and anti -platelet anti -platelet: Unscilance Sunigam with anticoagulants (heparin, warfarin), anti -platelets (aspirin, ticlopidin, clopidogrel) due to increased bleeding risk.

Pain relievers are selected COX 2: Avoid combining Sunigam with COX 2 inhibitors because of the increased risk of side effects on the gastrointestinal tract.

corticosteroids: Be cautious when coordinating Sunigam with corticosteroids due to an increased risk of ulcerative or stomach bleeding.

Cardiages and sulphonamide glycosides: Be careful when using Sunigam with cardiac glycosides or sulphonamid because the drug can worsen cardiac failure, reduce GFR and increase heart glycosides in plasma.

methotrexate: simultaneous use of Sunigam with methotrexate may reduce methotrexate excretion. Therefore, avoid high doses of methotrexat and use caution with low doses of methotrexate.

Lithium: Tiaprofenic acid increases the risk of lithium poisoning caused by lithium elimination.

Mifepriston: Aspirin and other NSAIDs should not use at least 8-12 days after using Mifepriston because NSAID drugs can reduce Mifepriston effect.

Diuretics: Be cautious when using Sunigam with diuretics because Tiaprofenic acid has both reduced diuretic and reduced the effectiveness of lower pressure and increased the risk of kidney failure, increased blood potassium. In addition, diuretics can increase the risk of toxicity on the body of NSAID.

tacrolimus: increases the risk of kidney toxicity when NSAID is used in combination with tacrolimus.

Zidovudin: Increases the risk of blood toxicity when NSAID is used with zidovudin.

Angiotensin II receptor inhibitors: Be careful when taking Sunigam with ACE inhibitors or Angiotensin II receptor blockers because of the risk of kidney function damage, including acute renal failure in patients with impaired renal function (such as patients who are dehydrated or elderly).

Seriously re -absorption inhibitors Serotonin (SSRIs): Be cautious when coordinating Sunigam with SSRIs because Tiaprofenic acid can increase the risk of gastrointestinal bleeding.

ciclosporin: The risk of kidney toxicity may increase if NSAID is used with ciclosporin.

Antibiotics Quinolon: Animal research data shows that NSAID may increase the risk of convulsions when combined with Quinolon antibiotics.

aminoglycosides or probenecid: Be cautious when using simultaneously Sunigam with aminoglycosid or probenecid.

Aminoglycosides interact with NSAIDs reducing kidney function in sensitive people, reducing aminoglycosides and increased plasma internal concentrations.

Probenecid interacts with NSAIDs reducing the metabolism and elimination of NSAIDs and its amplitude.

Storage

less than 30 ° C, avoid moisture and light.

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