Suntab Tablet Dongkoo Treatment of osteoarthritis symptoms (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Nabumetone

Ingredient

Composition information	Content
Nabumetone	500mg

Uses

Indications

Suntab Tablet is indicated in the following cases:

Treatment of acute and chronic symptoms of chronic osteoarthritis and rheumatoid arthritis (inflammation, swelling, stiffness and joint pain). The drug has the ability to inhibit the biosome of prostaglandin, which is an intermediate inflammation.

nabumetone is a precursor, after being transformed by biodegradation through the liver will produce 6 - methoxy - 2 naphthylacetic acid (6MNA) is an active ingredient with the ability to inhibit prostaglandin synthesis.

pharmacokinetics

After drinking, about 80% of the dose of nababetone marks the found in the urine. Nabumetone is not found in plasma, after being absorbed, Nabumetone is rapidly transformed into a main activity, 6-methoxy-2-naphthylacetic acid (6MNA). After taking a dose of 1000mg, about 35% is converted into 6mna and 50% converted into unknown substances and they are eliminated through water.

6MNA is connected to plasma proteins about 99%.

Used with food will increase the absorption rate and the appearance of 6MNA in plasma but does not affect the conversion of nababetone to 6MNA. The peak concentration of 6MNA in plasma increased by about 1/3.

Used with aluminum -containing acid -containing antacids does not significantly affect the bioavailability of 6MNA.

6MNA is metabolized through the liver to form inactive metabolites and are eliminated in two forms of free and combined form. About 75% of the marked dose is found in urine after 48 hours. After taking the dose of 1000 - 2000mg, the average plasma clearance is 20 - 30ml/min and the sale time is about 24 hours.

Before taking Suntab Tablet Dongkoo Treatment of osteoarthritis symptoms (10 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Adults

The starting dose is usually 2 tablets (1g), drink once a day in the evening before going to bed. Some patients may need a dose of up to 1.5 or 2g/day to reduce symptoms. Dosage can be adjusted depending on the patient.

Elderly

Like other drugs, Nabumetone concentration is usually higher than in the blood of the elderly. The daily recommendation does not exceed 1g, in most cases, the dose of 1 tablet (500mg/day) has shown a good response in these objects.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Disgusting, drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding can occur, hypertension, acute kidney failure, depression and coma may occur.

Handling

Patients need to be taken care of and treated symptoms. There is no specific antidote. Can cause vomiting or activated carbon drink (60 - 100g in adults, 1 - 2g/kg in children).

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Suntab Tablet you may experience unwanted effects (ADR).

Digestive system: Sometimes indigestion, nausea, vomiting, abdominal pain, constipation , flatulence, diarrhea, belching, esophagitis, peptic ulcer, hidden or massive gastrointestinal bleeding. Rarely gastric perforation, rectal inflammation, gastritis. Usually the above consequences are more serious in older patients. If used simultaneously with toxic drugs on the bone marrow, especially methotrexate, will be a favorable factor for blood cell decline. When taking aspirin and other non -steroid anti -inflammatory drugs including this drug, it is possible to start acute asthma attack. Serum or billirubin. It is very rare for hepatitis.

The risk of cardiovascular thrombosis (See more cautious part when used).

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Suntab Tablet contraindicated in the following cases:

Patients with a history of hypersensitivity to Nabumetone or any ingredients of the drug.

Patients with cross -sensitivity to aspirin and other non -steroide anti -inflammatory drugs: Patients who have signs of asthma, nasal polip, angioedema or urticaria after taking aspirin and other non -steroid anti -inflammatory drugs.

Patients with progressive stomach - duodenal ulcer.

Patients with severe liver failure.

Patients with severe kidney failure must not be hemorrhagic.

Children under 15 years old.

Pregnant and lactating women.

Precautions when using

such as other non -steroidal anti -inflammatory anti -inflammatorys, need to be cautious when taking this drug in patients with the above gastrointestinal disease or being treated with anticoagulants, need to monitor thoroughly in stomach - intestinal abnormal manifestations. Should stop taking the drug if the signs of ulcer or gastrointestinal bleeding.

As most of other non -steroid anti -inflammatory drugs, sometimes the drugs increase serum transaminase or other liver function indicators. In patients there are signs of impaired liver function or abnormal liver tests, so the progression and severity of the liver function should be determined during the medication period. There have been some serious reactions on the liver such as jaundice, hepatitis when taking non-minoride anti-inflammatory drugs. Although very rare, if the abnormalities in the testing of liver function are not lost and become worse or the appearance of systemic signs (eosinophilia, rash ...), then stop using nabumetone. Because Nabumetone's biological transformation into 6mna is dependent on liver function, the biological change can be reduced in patients with severe liver failure. Therefore, it is necessary to be cautious when using Nabumetone for patients with severe liver failure.

The combination treatment of anti -inflammatory drugs and painkillers only treat symptoms, not treatment.

When taking this medication to treat chronic symptoms, it is important to note the following factors: When taking the drug for a long time, regular tests should be checked (liver function test, blood formula ...) If there are abnormal signs, appropriate handling measures such as dose reduction or stop use of drugs.

When treating acute symptoms, note the following points:

Need to consider carefully in the school of severe acute, pain and fever.

It is necessary to treat the cause if possible.

Steroide anti -inflammatory anti -inflammatory anti -inflammatory anti -inflammatory anti -inflammatory anti -inflammatory anti -inflammatory anti -inflammatory anti -inflammatorys in the kidneys play a supportive role in kidney perfusion. Keeping water and causing edema is reported in some patients using Nabumetone. Therefore, like other nonsteroidal anti -inflammatory drugs, need to be cautious when taking drugs in patients with congested heart failure, high blood pressure.

Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, use systemic sugar, can increase the risk of cardiovascular thrombosis, including myocardial and stroke infarction, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly in high bureaucracy.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients should be warned of symptoms of serious cardiovascular events and need to visit the doctor as soon as they appear.

To minimize the risk of adverse events, the most effective daily daily dosage is needed in the shortest possible time.

The ability to drive and operate machinery

unknown.

Pregnancy

Safety levels in pregnant and lactating women have not been recorded. So do not use drugs for these objects.

Breastfeeding period

Contraindications.

Medicinal interaction

In clinical trials, the metabolic substance of Nabumetone is 6MNA strongly connected to the protein, so it is likely that other drugs at the position mounted on protein. Be cautious when using nababetone and warfarin for having an interaction between warfarin and other nonsteroidal anti -inflammatory drugs.

Nabuetone sharing with aluminum antacids does not affect the bioavailability of 6MNA. When used with food or milk, Nabumetone absorbs faster but the total amount of 6mna in the blood does not change.

ACE-Angiotensin converting enzyme (ACE-Angiotensin Converting): Studies show that NSAIDs reduce the effects of enamel inhibitors.

aspirin:

When using Namebutone simultaneously with NSAIDs, the ratio of associated with the protein of the drug is reduced, although Nabumetone's clearance does not change. Clinical manifestations have not been statistically, but the fact that other NSAIDs are not indicated simultaneously with Nambutone due to the ability to increase side effects.

Diuretics:

Clinical studies have shown that Namebutone can reduce the effects of diuretics to increase sodium discharge such as Furosemide and Thiazide in some patients. At the same time, because Namebutone also inhibits the formation of prostaglandin in the kidney, so when used in combination with NSAIDs, patients need to closely monitor the symptoms of kidney failure as well as ensure the effectiveness of diuretics.

lithium:

NSAIDS increases lithium concentration in plasma and reduces lithium's kidney clearance. The average lithium drug concentration increased by about 15% and the renal clearance decreased by about 20%. These effects are due to inhibition of the renal prostaglandin formation of NSAIDs. Therefore, if NSAIDS and Lithium use simultaneously, it is necessary to closely monitor the symptoms of lithium poisoning.

methotrexate:

NSAIDS is reported to be competitive on the excretion process with methotrexate. Therefore can cause toxicity of methotrexate. Caution when using simultaneously nambutone with methotrexate.

Storage

Store in closed packaging, at room temperature.

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