Sympal Merarini treat muscle pain, acute joint pain (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Dexketoprofen

Ingredient

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Composition information	Content
Dexketoprofen	25mg

Uses

indications

Sympal drugs are indicated in the following cases:

The drug is used to treat symptoms of acute to moderate acute pain, such as muscle pain or acute joint pain, dysmenorrhea, toothache. Dexketoprofen trometamol is tromethamine salt of acid S-(+)-2- (3-benzoylphenyl) propionic, an analgesic, anti-inflammatory and anti-fever, belonging to nonsteroidal anti-inflammatory drugs (M01AE).

The mechanism of impact of nonsteroidal anti -inflammatory drugs is associated with a decrease in prostaglandin through inhibition of cyclooxygenase path. In particular, the inhibitor of the transition process of arachidonic acid to endoperoxid, PGG2 and PGH2, the substance forming Prostaglandin PGE, PGE2, PGF2Q, PGD2 and Prostacycline PGI2, Thromboxan (TXA2 and TXB2). In addition, the synthesis of prostaglandin can affect other inflammatory intermediaries such as kinin, causing direct impact on direct resonance with direct impacts.

Dexketoprofen has been described as an inhibitor of COX-1 and COX-2 on humans and experimental animals. Clinical studies conducted on some pain models have shown the pain relief effect of dexketoprofen trometamol. In some studies, analgesic effect began to record at 30 minutes after taking the drug. Pain relief effect lasts for 4 to 6 hours.

pharmacokinetics

On the volunteer, after using dexketoprofen trometamol by oral, maximum cmax concentration achieved after 30 minutes (ranging from 15 to 60 minutes). Dexketoprofen trometamol's distribution and sale time are 0.35 and 1.65 hours respectively. As with other drugs with high plasma proteins (99%) ratio, the distribution of the drug has an average value of less than 0.25 1/kg.

The main excretion path of dexketoprofen is the glucuronic complex then eliminated through the kidneys. After drinking dexketoprofen trometamol is only the form of isomers S-(+) found in the urine, this shows that on the body, there is no process of shifting to isomer R-(-). Multi -dose pharmacokinetics studies have found that AUC after the last remedy is not different from the AUC value obtained when used for a single dose, showing no phenomenon of accumulation of drugs. When using the drug with meals, AUC does not change but the cmax of dexketoprofen trometamol decreases and the absorption rate is delayed (increase Tmax).

Before taking Sympal Merarini treat muscle pain, acute joint pain (2 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults

Sympal dose is needed for you depending on the form, severity and pain time, as directed by your doctor.

The usual recommendation is 1 tablet (25 mg) every 8 hours, not exceeding 3 tablets/day (75 mg).

Elderly people, or have liver and kidney disease, need to start with the dose not exceeding 2 tablets/day (50 mg). On the elderly, this starting dose may be increased to the usual recommended dose (75 mg Dexketoprofen) if the drug tolerance is good.

Severe pain and need to relieve pain quickly, take medicine when hungry (at least 30 minutes before meals) because the drug can be absorbed easily.

Patients with liver dysfunction

For patients with mild to medium liver dysfunction, it is advisable to start treatment at lower doses (50 mg/day) and should be closely monitored. Sympal should not be used for patients with severe liver dysfunction.

Patients with renal dysfunction

Initial dose for patients with mild renal function (creatinine clearance coefficient is 50 - 80 ml/min) is 50 mg/day. Sympal should not be used for patients with medium to severe kidney function (Creatinine clearance ratio

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose? Remember to bring the drug box or instruction sheet.

What to do when forgetting a dose? Take the next dose at the prescribed time.

If you have any more questions about the use of the drug, ask your doctor or pharmacist.

Side Effects

When using Sympal, you may experience unwanted effects (ADR).

Common, ADR> 1/100

vomiting and/or vomiting, stomach pain, diarrhea, digestive disorders.

Less

Feeling dizziness, drowsiness, drowsiness, bad sleep, anxiety, headache, brushing chest, blushing, thick pain, constipation, dry mouth, flatulence, fatigue, pain, cold or cold, tired body.

Rare

Stomach ulcers, bleeding or puncture (can be detected when vomiting blood or black stools), fainting, hypertension, slow breathing, water retention and peripheral edema (eg ankle swelling), anorexia, abnormal, itching, increased sweat, back pain, menstrual disorders, hepatitis abnormalities, hepatitis, abnormalities (blood damage) impaired renal function (acute renal failure).

Very rare

Anaphylaxis reaction (hypersensitivity reaction can lead to cardiovascular collapse), sores on the skin, mouth, eyes and genital organs (Stevens Johnson syndrome and lyell syndrome), facial edema or lip edema, throat (angioedema), difficulty due to gas narrowing (bronchial spasms), short breath, fast heartbeat, hepatitis, pancreatitis, skin damage, fuzzy skin, blurring skin, blurring skin Hypersensitivity to light, itching, kidney problems. Leukopenia may be encountered, thrombocytopenia in the blood.

Notice to the doctor immediately if you experience any unwanted effects on the stomach/intestines when starting to use the drug (e.g. stomach pain, heartburn or bleeding), stating you have encountered any unwanted reactions due to anti -inflammatory drugs for a long time, especially in the elderly. Stop using Sympal as soon as you feel burning, or any lesions in your mouth, on the genital organs or any signs of allergies. Drugs like Sympal may be associated with a slight increase in the risk of heart mutation ("myocardial infarction") or a stroke (cerebral mutation). In patients, there is a system immune disorder related to connective tissue (IUPUS you red system or connective tissue disease), anti -inflammatory drugs that can cause fever, headache and stiffness at a rare frequency.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Sympal drugs contraindicated in the following cases:

Allergy (hypersensitivity) with dexketoprofen trometamol or with any component of Sympal.

allergies to acetylsalicylic acid (aspirin) or with other nonsteroidal anti -inflammatory drugs.

Just undergoing acute asthma, acute allergic rhinitis, nasal polyps (tumors in the nose due to allergies), urticaria (burning on the skin)), angioedema (swelling of the face, eyes, tongue, tongue or meditating) or wheezing in the chest after using aspirin or other non -steroid anti -inflammatory colonies.

Being or having had stomach ulcers, stomach bleeding, intestines or chronic gastrointestinal diseases (for example, indigestion, heartburn); Having gastrointestinal bleeding, stomach perforation due to the use of nonsteroidal anti -inflammatory drugs to treat pain.

Chronic bowelitis (Crohn's disease or colon ulcer); severe heart failure, medium to severe kidney disease or severe liver disease; There is bleeding disorders or coagulation disorders.

in the last 3 months of pregnancy or breastfeeding.

Children and teenagers are younger than 18 years old.

Be cautious when using

Patients who are allergic or have a history of allergies in the past.

Patients with liver, kidney, heart (hypertension and/or heart failure) disease as well as fluid holding, or have this pathology in the past.

People who are using diuretics or water are very small and reduced the volume of circulatory due to excessive fluid loss (e.g. due to vomiting, external or excessive urine).

People with cardiovascular disease, have been unexpectedly or may be at risk of this condition (for example, when you have hypertension, diabetes, hypercholic cholesterol or smoking), you should consult your doctor or pharmacist. Medications like Sympal may be associated with a slight increase in the risk of heart mutation ("myocardial infarction") or a stroke (brain mutation). These risks can be higher when taking high doses and treatment for a long time. Do not exceed the dose and the recommended treatment period.

For the elderly: You may be at higher risk of unwanted reactions. If any adverse reaction appeared, immediately consult a doctor.

Women are having reproductive problems (Sympal can reduce fertility, so this drug should not be used if you plan to get pregnant or perform tests to assess fertility).

Patients with abnormalities in blood formula or blood formation process.

Patients with systemic lupus or coordinated connective tissue disease (system autoimmune disease that affects connective tissue).

Patients who have had chronic inflammatory infections (colon ulcers, Crohn's disease), or have had other diseases related to the stomach and intestines.

The ability to drive and operate machinery

Sympal may have a mild effect on the ability to operate train machinery because it can cause unwanted effects as dizziness, visual disorders. If you notice these signs, do not drive or use machines until the symptoms disappear. Need to consult a doctor.

pregnancy

should not use the Sympal in the last 3 months of pregnancy.

Notify the doctor if you are pregnant or intend to get pregnant, because the Sympal may adversely affect them.

breastfeeding period

should not use Sympal for nursing women. Need your doctor's advice in this case.

Medicinal interaction

inform your doctor or pharmacist if you are using or have just used any other drug, including non -prescribing drugs. There are some drugs that should not be taken with or need to adjust the dose when used simultaneously.

Drugs should not be used with:

Acetylsalycilic acid (Aspirin), corticostereiide or other anti -inflammatory drugs. Letter.

Medications need to be cautious when using:

Transfer inhibitors, diuretics, beta receptor inhibitors and angiotensin II receptor blockers, used to treat hypertension and heart disease.

pentoxifylin and oxpentifylin, used to treat chronic intravenous ulcer.

The drugs to note when used:

Quinolon antibiotics (for example, ciprofloxacin, levofloxacin) used to treat infections.

Probenecid: used in gout treatment. Blood clots.

Storage

Cool dry place, avoid light, at temperatures below 30ºC.

Keep the drug in the outer paper box to avoid light. To be out of reach and vision of children.

Do not throw the medicine into water or waste. Consult your pharmacist how to destroy unworthy drugs. This measure will contribute to environmental protection.

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