Synvetri levetiracetam syrup treatment for partial and children (100ml) seizures (100ml)

Dosage form Bottle
Specifications Levetiracetam

Ingredient

Composition information	Content
Levetiracetam

Uses

indications

Synvetri drugs are indicated in the following cases:

Levetiracetam is used as a supplementary therapy in the treatment of partial epilepsy in adults and children 4 years and older with epilepsy.

levetiracetam prevents selectivity of high excitement nerve cells leading to epilepsy and preventing the spread of epilepsy.

Dynamic pharmacokinetics

absorption and distribution:

levetiracetam hap quickly, with peak plasma concentrations appear for about an hour later with low -fat food (vegetarian food). Levetiracetam oral bioavailability is 100%, the tablet and oral solution are equivalent to the speed and level of absorption. Food does not affect the absorption of levetiracetam but it reduces 20% cmax and slows down TMAX to 1.5 hours.

transformation:

levetiracetam does not metabolize much in the human body. The metabolic path is the hydrolysis process of the acetamid group with enzymes, creating metabolites is carboxylic acid, UCB L057 (24% dose) and does not depend on any liver's Cytochrom P450 system.

excretion:

Levetiracetam's semi -discharged time in adult plasma is 7 ± 1 hour and is not affected by the dose or repeated use. Levetiracetam is eliminated from the circulatory system by excreting through the kidneys in the form of unchanged. The body clearance coefficient is 0.96 ml/min/kg and the kidney is 0.6 ml/min/kg. The mechanism of the excretion is glomerular filtration and partial reactivation in the renal tubules.

Before taking Synvetri levetiracetam syrup treatment for partial and children (100ml) seizures (100ml)

How to use

Use the dose lid to drink levetiracetam.

Dosage

16 years and older:

Starting dose: 1000 mg daily with oral or intravenous tablet, dose: 500 mg twice daily. Increasing additional dosage can be (an increase of 1000 mg/day after every 2 weeks) to the highest dose as recommended by 3000 mg/day. There is no evidence that the dose greater than 3000 mg/day offers additional benefits.

Usual dose in children with convulsions:

Mechanical seizures:

Oral

Children aged 12 years and older: Initially: 500 mg twice daily; May increase every 2 weeks 500 mg/dose to the highest recommended dose is 1500 mg twice daily. The effect of the dose greater than 3000 mg/day has not been verified.

Local epilepsy:

Oral

Children 1 month or less than 6 months of age: 7 mg/kg/dose 2 times daily (14 mg/kg/day), can increase every 2 weeks 14 mg/kg to the recommended daily dose of 42 mg/kg.

Children from 6 months to under 4 years old: 10 mg/kg/dose twice daily (20 mg/kg/day), can increase every 2 weeks 20 mg/kg to the recommendation of daily use is 50 mg/kg (25 mg/kg twice daily). The daily dose of 50 mg/kg may be reduced in patients who cannot withstand this dose.

Children 4 years old to under 16 years old: 10 mg/kg/dose twice daily, can increase every 2 weeks of 10 doses/mg/kg to the recommended dose of 30 mg/kg/dose twice daily (60 mg/kg/day). The daily dose of 60 mg/kg may be reduced in patients who cannot build this dose.

Children aged 16 and over: Refer to adult dose.

Maximum dose: 3000 mg/day.

Adjustable dose when renal failure:

Dosage should be reduced for patients with impaired renal function.

For adults:

Quick release type:

Creatinine clearance: greater than 80 mg/min, dose from 500 to 1500 mg every 12 hours. 30 mg/minute, dose from 250 to 500 mg every 12 hours.

For children:

Creatinine clearance less than 50 ml/min/1.73 m2: Use 50% dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? In addition to drowsiness, there is no side effects in several known overdose in clinical trials. In case of drowsiness, agitation, aggression, reducing the level of awareness, respiratory failure and coma is monitored with overdose of levetiracetam in drug circulation reports.

control overdose

There is no specific antidote for levetiracetam overdose. If indicated, try to remove the drug that is not absorbed by causing vomiting or gastric lavage. Common preventive measures should be followed to maintain airway. General support for patients appointed patients including monitoring important signs and observing the patient's clinical status. Should contact the reliable toxic control center to update information about overdose use with levetiracetam.

Hemataloagia

Using the method of blood decomposition increases significantly with levetiracetam (approximately 50% in 4 hours) and should be considered in case of overdose. Although the blood decomposition has not been done in several cases of overdose. It may be indicated according to the patient's clinical condition or with patients with significant renal failure.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Synvetri drugs often have unwanted effects (ADR) such as:

Levetiracetam has been studied in clinical trials. In this study, the most common side effects of levetiracetam include:

Sleep - up to 23%. 13%.

cough - up to 11%. , constipation, conjunctivitis, dementia, abnormal feeling: such as burning, tingling or numbness, sinus infection, double vision, asthma, skin color change, eye fatigue, ear pain.

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Synvetri drugs contraindicated in the following cases:

Hypersensitivity to the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Used in patients with renal failure:

Levetiracetam clearance decreases in patients with renal impairment and correlate with the degree of creatinine. Dosage adjustment is recommended for patients with renal impairment and additional dose should be used after dialysis patients.

For the elderly:

Elderly patients are more likely to impaired renal function, paying attention should be performed in choosing the dose and it can be helpful to monitor kidney function.

for children:

The safety and effectiveness of levetiracetam in the support of the support of local seizures in children aged 1 month to 16 years of age suffering from epilepsy, treatment of muscle seizures in teenagers aged 12 and older with teen muscle seizures, epilepsy treatment all established.

The effect of the drug on the ability to drive and operate machinery

does not have sedative effects, effects that can affect the ability to handle the machine, known when using levetiracetam.

Using drugs for women during pregnancy and lactation

Levetiracetam concentration may decrease during pregnancy.

Drugs are c:

There is no adequate and well -controlled research in pregnant women. In animal studies, there is evidence related to the use of levetiracetam to the increase in toxicity, including the teratogenic effect, with the same dose or greater than the dose of human treatment.

levetiracetam is used during pregnancy only when there is a potential benefit greater than the risk for the fetus.

In case of milking with milk:

levetiracetam is excreted in breast milk. Because of the ability to seriously respond to breastfeeding from levetiracetam, deciding to stop breastfeeding or stopping medicine, advising on the importance of the mother.

Interactive drug

There is no significant interaction of pharmacokinetics monitored between levetiracetam or its main metabolic path with simultaneous drugs through the CYP450 enzyme system in human liver, Epoxide hydrolase enzyme, UDP-glucuronidation, p-glycoprotein, or excreted by kidney.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children, read the user manual carefully before use.

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