Syrup Rinofil 2.5mg/5ml Abbott reduces allergic rhinitis (15ml)

Dosage form Vial X 15ml
Specifications Desloratadine

Ingredient

Composition information	Content
Desloratadine	2.5

Uses

Indications

Rinofil syrup 2.5 mg/5 ml is indicated in the following cases

The drug is prescribed in patients greater than 6 months old. Selective inhibitors H1 H1 three long -term effects. Desloratadin inhibits histamine released from In vitro. After drinking, desloratadin selectively inhibits the peripheral H1 histamine receptors because the drug cannot completely penetrate into the central nervous system.

Desloratadin also has anti -allergic effects from in vitro studies. Inhibiting the release of inflammatory cytokines such as IL-4, IL-6 and IL-13 from moisturizing as well as inhibiting the release of the p-selectin-adhesive molecules of the membrane in the cell.

pharmacokinetic

can detect desloratadin concentration in plasma within 30 minutes after taking the drug. Desloratadin absorbs well to the peak concentration in plasma after about 3 hours, the sale time is about 27 hours. The accumulation of desloratadin is suitable for the sale time (about 27 hours) and a dose once a day. The bioavailability of desloratadine is proportional to the dose within 5 - 20 mg.

Desloratadin is moderately linked to plasma proteins (83 - 87%). There is no evidence of clinical accumulation after taking a dose of 5 - 20 mg daily in 14 days.

It is not known to be responsible for metabolism of desloratadin, so it has not completely excluded the interaction with some other drugs. Desloratadin does not inhibit CYP3A4 and CYP2D6, nor is the substrate or inhibitor P-Glycoprotein.

Testing for single dose of 7.5 mg Desloratadin dose, no effect of food (breakfast rich in fat and energy) on pharmacokinetics of Desloratadin.

Before taking Syrup Rinofil 2.5mg/5ml Abbott reduces allergic rhinitis (15ml)

How to use

Rinofil syrup 2.5 mg/5 ml is used orally. Drugs can be taken with food or away from meals.

Dosage

Common dose of adults and children over 12 years old: 5 mg (10 ml of syrup)/1 time/day.

Note: In patients with liver and kidney dysfunction, the starting dose is recommended: 5 mg in Japan.

Children are commonly used:

Children from 2-5 years old: 1.25 mg (2.5 ml)/1 time/day. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In case you suspect overdose, must go to the medical center immediately.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Rinofil Syrup 2.5 mg/5 ml, you may experience unwanted effects (ADR).

This medication may occur the following effects without seeing a doctor unless they are too uncomfortable or does not disappear during treatment:

happens more often

headache, sore throat (body pain: congestion, cough, dry or sore throat; fever;

rarely occur

Dizziness, dry mouth, dysmenorrhea, digestive disorders (stomach acid, flatulence, heartburn, indigestion, stomach discomfort), tiredness, muscle pain (pain or arthritis, muscle pain, crushing, difficulty moving), drowsiness, nausea.

Notify the doctor with unwanted effects when using the drug.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Rinofil Syrup 2.5 mg/5 ml contraindicated in cases where patients have a history of hypersensitivity to desloratadine or Loratadine or any ingredient of the drug.

Precautions when using

Notice to your doctor if you have an allergic reaction when using desloratadin or with any other substance (food, color, ...) or other drugs.

Notify the doctor if you are pregnant or breastfeeding.

For children: Safety and effectiveness of Desloratadin in children under 6 months of age has not been established.

Notify the doctor if the symptoms do not improve after two days of treatment.

Notice your doctor who is taking this medicine before you try allergies in the skin.

Avoid drinking alcohol or medication to soothe the central nervous system (for example, tranquilizer, sleeping pills, antidepressants) during treatment.

Notify your doctor if you have a history or if you have diseases: kidney disease, liver disease.

The ability to drive and operate machinery

For the recommended dose, this drug rarely causes drowsiness, reduces vigilance or obstructing the ability to drive train and control machinery.

Pregnancy

is not recommended unless there is a strict follow -up of the doctor.

Breastfeeding period

is not recommended unless there is a strict follow -up of the doctor.

Drug interaction

There is no related drug interactions on clinical trials with erythromycin or ketoconazole when taken together. However, enzymes are responsible for the metabolism of desloratadin have not been recognized, and so some interactions with other drugs may not be completely excluded.

In clinical pharmacokinetic research, drinking the same desloratadin and alcohol does not increase the harmful effects of alcohol.

Storage

In a dry place, avoid light, temperature below 30 ° C.

Expiry date: 24 months from the date of manufacture. Do not use overdue drugs stated on the packaging.

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Disclaimer

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