Tacroz 0.03% Glenmark ointment treatment for medium and severe atopic dermatitis (10g)

Dosage form Tube x 10g
Specifications Tacrolimus

Ingredient

Composition information	Content
Tacrolimus	0.03%

Uses

indications

Tacrolimus ointment is short -term or long -term intermittent intermittent or medium and severe dermatitis patients, but the use of traditional treatments is not appropriate because of the potential risks or these patients respond to incomplete, or intolerance to traditional treatments.

Pharmacokology

unknown mechanism of exact effects of Tacrolimus on atopic dermatitis. Tacrolimus has been shown to inhibit the activity of T lymphocytes by attaching an intracellular protein, FKBP -12, then formed the complex of Tacrolimus - FKBP12 - Calcium, Calmodulin and Calcineurin, and inhibit the phosphatase activity of calcineurin. This effect prevents Dephosphorylation process and the transport of factors in the nucleus of active T cells (NFAT), a component in the nucleus has the effect of starting the genetic copy to form lymphokin (such as interleukin-2, gamma interferon).

Tacrolimus also inhibits the copy of genes with IL-3, IL-4, IL-5, GM-CSF, and TNF-(Alpha), (Alpha), these are genes in the early stages of T. In addition, Tacrolimus also has the effect of inhibiting the release of chemical mediators from mast cells and favorite base cells, reducing the adjustment effect Langerhans.

pharmacokinetics

The whole body absorption of Tacrolimus used on the spot is negligible. After taking 0.1% or more doses of Tacrolimus ointment, the blood peak concentration of Tacrolimus varies from non -detected levels of up to 20 ng/ml. As a result, a pharmacokinetic study of Tacrolimus ointment on 20 patients with atopic dermatitis (6 - 13 years old) showed that the peak concentration of Tacrolimus in the blood was less than 1.6 ng/mL per patient.The absolute use of Tacrolimus is not known on the spot. Use previous venous data to compare the bioavailability of Tacrolimus in Tacrolimus ointment in patients with atopic dermatitis less than 0.5%. In adults, the exposure level (measured in AUC) with Tacrolimus is 30 times lower than oral medication to inhibit immunosuppressants in liver and kidney transplant patients. It is not seen that Tacrolimus accumulates the whole body based on blood concentration when used on the spot without continuous for a period of a year.

Before taking Tacroz 0.03% Glenmark ointment treatment for medium and severe atopic dermatitis (10g)

How to use

Apply a thin layer of tacrolimus fat to the infected skin twice a day and massage gently. Should continue treatment for an extra week after all the signs and symptoms of atopic dermatitis.

Not evaluated safety when wounding the wound using Tacrolimus ointment as it can increase the body absorption. Therefore, the wound should not be covered when using Tacrolimus ointment 0.03%.

Dosage

Adults

Tacrolimus ointment 0.03% twice a day.

Children (2 - 15 years old)

Tacrolimus ointment 0.03% twice a day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Tacrolimus ointment also causes unwanted effects such as using Tacrolimus. If you swallow the medicine, immediately consult a physician.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Tacroz, you may experience unwanted effects (ADR).

On the skin: burning, itching, redness, throbbing, folliculitis, acne, herpes simplex (herpes, ulcers, herpes Eczema, Kaposi chickenpox).

Nervous system: increase sensation (increase skin sensitivity, especially with hot and cold).

The whole body: alcohol intolerance (blushing or skin irritation after alcohol -containing drinks).

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

tacrolimus is contraindicated for patients with a history of sensitivity to Tacrolimus or any component of the drug, pregnant and lactating women.

Be cautious when using

Tacroz ointment is only used on the skin.

Tacroz ointment is not for eyes, mouth or vagina.

No assessment of the safety and effectiveness of Tacrolimus ointment in the treatment of allergic dermatitis is infected. Therefore, it is necessary to treat infections before taking Tacrolimus ointment at the positions to be treated.

Patients with atopic dermatitis easily lead to shallow skin infections including herpes eczema (Kaposi chickenpox). Treatment with Tacrolimus ointment may increase the risk of Varicella Zoster virus infection (chickenpox or shingles), Herpes Simplex, herpes Eczema. In such bacterial infections, it is necessary to assess the risk and benefits of treatment when taking Tacrolimus ointment to decide whether or not.

Organs patients who are using immunosuppressants (such as Tacrolimus using systemic sugar) may increase the risk of lymphoma. Therefore, for patients using Tacrolimus ointment and people with lymph nodes, it is necessary to find out the cause of lymph nodes of these patients.

In the case of unknown cause of the disease or showing signs of hyperlemen in acute infection, it is necessary to stop treating with Tacrolimus. For patients who are suffering from lymph nodes, need to be closely monitored to make sure the lymph nodes are cured.

Patients should limit or avoid exposure to natural or artificial light (skin treatment beds with UVA/B) while taking Tacrolimus ointment.

Local symptoms (burning sensation, throbbing, skin ulcers) or itching are the most common symptoms in the first few days of using Tacrolimus ointment. They will gradually decrease when allergic dermatitis lesions are cured.

Do not use Tacrolimus ointment for patients with Nethiton syndrome due to increased risk of absorbing the whole body of Tacrolimus. Safety when using Tacrolimus ointment for unprocessed systemic erythema patients.

The ability to drive and operate machinery

does not affect.

Pregnancy

There is no enough research data on pregnancy. This drug is only used for pregnant women when prescribed by a doctor.

Breastfeeding period

tacrolimus excreted through breast milk. Therefore, it is necessary to consider stopping breastfeeding or stopping the drug, depending on the importance of the drug for the mother.

Drug interaction

There is no studies on interaction of Tacrolimus ointment with other skin medicines. Based on the low absorption level of Tacrolimus, rarely occurs the interaction of the drug with systemic drugs, but still does not exclude this possibility. Caution should be used with simultaneous use of CYP3A4 inhibitors on patients who use widespread medication and/or skin redness, such as using erythromycin, otraconazole, ketoconon, fluconazole, Calci and cimetidin inhibitors.

Storage

Store less than 30 ° C, not to freeze. Leave at the reach of children. Do not use expired drugs. Use within 3 months from opening.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.