Tacroz Forte 0.1% Glenmark ointment treatment for atopic dermatitis (10g)

Dosage form Tube x 10g
Specifications Tacrolimus

Ingredient

Composition information	Content
Tacrolimus	0.1%

Uses

Indications

Tacroz Forte is indicated in the following cases:

Treatment of outbreaks: Adults and adolescents (16 years and older): 0.1% tacrolimus ointment is indicated for treatment of atopic dermatitis has just been severe in adults inadequate or inadequate tolerance of traditional tri -cashew therapies such as local corticosteroids.

Maintain treatment: Treatment of atopic dermatitis has just been severe to prevent outbreaks and extend the time when there is no outbreak in patients with a high frequency of illness (for example, 4 times or more each year) has an initial response with a maximum of 6 weeks of treating Tacrolimus opening 2 times daily (clean damage, almost clean or only minor damage). Learning

The mechanism of action of Tacrolimus in atopic dermatitis has not been fully understood. While the following has been observed, the clinical significance of these observations in atopic dermatitis has not been known.

Through its link with a specific cytoplasmic immune immunity (FKBP12), Tacrolimus inhibits the signal transmission pathway dependence in T cells, thus preventing the code and synthesis of IL - 2, IL - 3, IL - 4, IL - 5 and other cells as in the form of GM - CSF, TNF - α and IFN - γ.

pharmacokinetic

absorption

tacrolimus absorbs less or not absorbed into the blood after applying the skin of a single -dose or repeating Tacrolimus ointment.

Distribution

After applying the Tacrolimus ointment on the spot, Tacrolimus is selected into the skin with a minimum diffusion into the circulatory system.

Metabolism

The metabolism of Tacrolimus through the skin is not detected. Tacrolimus is available in the system that is metabolized in the liver through CYP3A4.

Elimination

After applying the ointment many times, the average half -life of Tacrolimus is estimated to be 75 hours for adults and 65 hours for children.

Before taking Tacroz Forte 0.1% Glenmark ointment treatment for atopic dermatitis (10g)

How to use

Tacrolimus ointment should be applied to a thin layer to the affected or often affected skin areas.

Tacrolimus ointment can be used on any part of the body, including the face, neck and bending area, except on the mucous membrane.

Do not use tacrolimus ointment when icy because this method has not been studied in patients.

Dosage

Exacentive treatment:

Adults and children over 16 years: 2 times/day until clean or only mild. If there is an outbreak, the treatment should be started again. If responded well, it can reduce the frequency of topical topics. After 2 weeks, there is no improvement in need of other suitable treatment.

Elderly: No dose adjustment.

Maintain treatment:

Initially responded well with 2 times/day for 6 weeks of using the drug (clean skin damage or only mild condition) suitable for continuing maintenance treatment.

Dose: 2 times/week. Should be 2 - 3 days apart do not use the drug (such as Monday, Thursday).

After 12 months, it is necessary to assess the current condition of the disease to decide or not.

If the disease breaks out, it starts 2 times/day.

The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

If eaten, general support measures may be appropriate. They may include monitoring important signs and observing clinical status. Due to the nature of ointment, do not cause vomiting or gastric lavage.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Tacroz Forte , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Common and local disorders: warm, erythema, pain, irritation, abnormalities. rash in a place of drugs.

Infection and poisoning: Local skin infection regardless of the specific cause: Eczema Herpeticum, Folliculitis, Herpes Simex , Herpes virus infection, Kaposi chickenpox.

Disorders of metabolism and nutrition: Flushing or irritating skin after drinking alcoholic beverages.

Nervous system disorders: Perception and sympathy (hypersensitivity, burning sensation).

Skin and tissue disorders: itching.

Uncommon, 1/1000

Skin and tissue disorders: Acne.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications

Hypersensitivity to active ingredients, macrolid in general, or any excipients of the drug.

Precautions when using

should minimize skin contact with sunlight and avoid UV rays from sunbathing, UVB or UVA rays combined with Psoralens (PUVA) during the use of Protopic ointment. Protopic ointment should not be applied to lesions that are considered malignant or malignant.

The use of Tacrolimus ointment is not recommended in patients with skin fence defects, such as Netherton syndrome, skin spot disease, body red blood cells or skin graft disease. These skin conditions can increase the whole body absorption of Tacrolimus.

Be careful if using Tacrolimus for patients with widespread skin damage for a long time, especially in children.

Patients with lymphadenopathy during treatment should be monitored to ensure that the ganglion will cure.

Tacrolimus treatment is associated with an increased risk of folliculitis and herpes virus infection. When there are these infections, it is necessary to assess the balance between risks and benefits related to use.

Software should not be applied to the same area within 2 hours after using Tacrolimus ointment. The simultaneous use of other topical topical preparations has not been evaluated. There is no experience in simultaneous use of systemic steroids or immunosuppressants.

Be careful to avoid contact with the eyes and mucosa. If accidentally applied to these areas, Tacrolimus ointment must be cleaned and/or washed with water.

The use of tacrolimus ointment under the icy ice has not been studied in patients. The irregular bandage is not encouraged.

Wash your hands after applying if your hands are not used for treatment.

tacrolimus should be used cautiously in patients with liver failure and patients at risk of renal failure.

The ability to drive and operate machinery

Tacrolimus ointment is not directed or negatively affected by the ability to drive and operate the machine.

Pregnancy

Non -tacrolimus ointment should be used during pregnancy unless necessary.

Breastfeeding period

Breastfeeding during treatment with Tacrolimus ointment is not recommended.

Medicinal interaction

The official studies on skin interaction with skin with Tacrolimus ointment have not been conducted.

tacrolimus is not metabolized in human skin, indicating that there is no ability to interact through the skin may affect the metabolism of Tacrolimus.

tacrolimus is available in the system transformed through Cytochrome P450 3A4 (CYP3A4) in the liver. Exposure to the whole body when applying Tacrolimus ointment is low ( Itraconazole , ketoconazole and diltiazem) in patients with widespread red blood cells and/or need to be done cautiously.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.